2- (2- cresyl)- 4H- 1- 3- 2- benzodioxaphosphorin- 2- oxide

cyclic metabolite of tri-o-cresyl phosphate; synergist for cholinesterase inhibitors

Also Known As:

0-tosylsaligenin phosphate; 2-(o-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide; 2-TSLPH; 2-tolylsaligenin phosphate; 2-tosylsaligenin phosphate; CBDP; SCOTP; cresylsaligenin phosphate; o-TSP; saligenin cyclic-3-tolylphosphate; 4H-1,3,2-Benzodioxaphosphorin, 2-(2-methylphenoxy)-, 2-oxide

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide: 9

Experts

1.	Chen, Ying: 1 article (09/2022)
2.	He, Zuyang: 1 article (09/2022)
3.	Sun, Xingwen: 1 article (09/2022)
4.	Wang, Shangfeng: 1 article (09/2022)
5.	Yao, Chenzhi: 1 article (09/2022)
6.	Yin, Dongrui: 1 article (09/2022)
7.	Yu, Peng: 1 article (09/2022)
8.	Zhang, Fan: 1 article (09/2022)
9.	Goncharov, Nikolay V: 1 article (12/2021)
10.	Jenkins, Richard O: 1 article (12/2021)

Related Diseases

1.	Poisoning 12/20/2021 - "In the second model (M2, CBPOX group), 1 h prior to POX poisoning at a dose of 130 µg/kg subcutaneously, carboxylesterase activity was pre-inhibited by administration of specific inhibitor cresylbenzodioxaphosphorin oxide (CBDP, 3.3 mg/kg intraperitoneally). " 09/01/2010 - "In mice, the combination of the carboxylesterase inhibitor 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP) with the organophosphorus (OP) nerve agent GB renders mice more sensitive to OP poisoning. " 07/11/1979 - "The protective index of atropine + HS-3 in sarin poisoning, as in the case of soman poisoning, was much higher in CBDP pretreated than in control animals (20.1 : 13.6), only slightly higher in tabun poisoning (4.3 : 3.4) and in the case of VX poisoning lower in CBDP pretreated than in control animals (32 : 47). " 07/11/1979 - "The protective effect of atropine and the oximes HS-3, HS-6 and HI-6 in soman poisoning was much greater in CBDP pretreated than in control animals. "
2.	Organophosphate Poisoning 07/11/1979 - "The influence of 2-/o-cresyl/-4 H-1 : 3 : 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy."
3.	Choledocholithiasis 01/01/2022 - "The objective was to describe the changes of CBDP after open surgical exploration in patients with choledocholithiasis, considering clinical scenarios in remote locations. "
4.	Spasm (Spasms) 06/01/1986 - "Common bile duct pressure (CBDP) did not differ significantly between the SPO spasm group and control patients, but in the fentanyl test the CBDP elevation was significantly higher (p less than 0.01) than in controls (7.7 versus 3.3 mm Hg). "
5.	Neoplasms (Cancer) 10/01/2004 - "The inhibitory effect of CBDP, HO-TOTP, and 3-BCP on FAEE synthase and esterase activity was studied using rat hepatic and pancreatic postnuclear (PN) fractions, commercial porcine hepatic CE and pancreatic ChE, and in HepG2 and rat pancreatic tumor (AR42J) cell lines. "

Related Drugs and Biologics

1.	Carboxylesterase (Hydrolase S)
2.	Oxides
3.	Soman
4.	Sarin
5.	Oximes
6.	Fibronectins (Fibronectin)
7.	Fentanyl (Sublimaze)
8.	Esterases
9.	Endotoxins
10.	Atropine

Related Therapies and Procedures

1.	Therapeutics