dixanthogen (EXD)

Also Known As:

EXD; Auligen; Bexide; Herbisan; O,O-diethyl dithiobis(thioformate); O,O-diethyl dithiobisthioformate; Sulfasan; bisethylxanthogen; diethyl dithiobis(thionoformate); diexanthogen; ethyl xanthogen disulfide

Networked: 55 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Han, Ting: 5 articles (01/2012 - 07/2008)
2.	Tong, Yao: 4 articles (01/2017 - 01/2012)
3.	Qin, Luping: 4 articles (01/2012 - 07/2008)
4.	Zhang, Qiaoyan: 4 articles (01/2012 - 07/2008)
5.	Kamei, Satoshi: 3 articles (04/2012 - 03/2008)
6.	Wang, Yin: 3 articles (01/2012 - 01/2011)
7.	Xue, Liming: 3 articles (01/2012 - 01/2011)
8.	Wong, Man-Sau: 2 articles (07/2021 - 01/2014)
9.	Cook, Brian: 2 articles (12/2020 - 01/2015)
10.	Shou, Dan: 2 articles (09/2019 - 01/2019)

Related Diseases

1.	Osteoporosis 09/15/2019 - "Our work successfully identified the main active components in EXD, which could represent the efficacy of EXD on treating osteoporosis, and meanwhile, it also provided an effective strategy to investigate active ingredients from natural medicines, which might be helpful for drug development and application." 01/01/2017 - "Eight trials including 644 patients investigated the effects of EXD in the treatment of osteoporosis. " 01/01/2017 - "All randomized controlled trials of EXD for osteoporosis were included. " 01/01/2014 - "In the present study, the in vivo anti-osteoporosis effects of EXD, HEP and XM on four-month-old ovariectomized (OVX) Sprague-Dawley rats were investigated. " 09/15/2019 - "According to network pharmacology result, M-EXD consisted of 13 ingredients since they had a close relationship with 65 osteoporosis-related targets. "
2.	Bone Resorption 01/01/2012 - "The present study found that EXD, EBH, and ICA treatments, emulating estrogen, significantly contributed to bone density and architecture in OVX rats and that EXD is similar to estrogen and exerts a concomitant effect on bone formation and bone resorption at the tissue level, while EBH and ICA produced bone-protective effects mainly by inhibiting bone resorption. " 07/05/2010 - "We found that EXD at a concentration of 50-200 microg/mL significantly enhanced osteoblastic UMR-106 cell proliferation, alkaline phosphatase (ALP) activity and formation of bone nodules, and decreased tartrate-resistant acid phosphatase (TRAP) activity and the bone resorption action of osteoclasts induced from RAW 264.7 cells. " 01/01/2012 - "Er-Xian decoction (EXD), a traditional Chinese medicine, has been reported to have a protective effect against bone loss in ovariectomized osteoporotic rats, and the inclusion of icariin (I), curculigoside (C), and berberine (B) in EXD displays inhibitory effects on osteoclastic bone resorption. "
3.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2013 - "This study aimed to differentially investigate the efficacy of EXD and its antimetastatic property on human ovarian cancer cells, OVCA429. " 07/01/2013 - "This is the first study that illustrates the antimetastatic property of EXD on human ovarian cancer models. "
4.	Edema (Dropsy) 11/01/2022 - "EXD inhibits apoptosis by activating Akt1, reduce spinal cord edema and restore behavioral function after SCI in rats." 11/01/2022 - "In vivo studies have shown that EXD improved motor function at 7dpi in SCI rats (P < 0.0001), significantly reduced spinal cord edema (P = 0.0139), upregulated 5-HT, GFAP, and TMEM119 expression. "
5.	Neoplasms (Cancer) 01/01/2013 - "The anti-angiogenic activity of EXD provides new insights to its clinical application and may lead to potential drug development for treating various cancers, especially in menopausal period in the future." 01/01/2012 - "The anti-angiogenic activity of EXD provides new insights to its clinical application and may in the future lead to the development of potential drugs for treating various cancers, especially in menopausal period." 07/01/2013 - "EXD suppressed tumor size in xenografts without any adverse effects on body weight. " 07/01/2013 - "This decoction merits serious consideration for further delineation of its multiple pharmacological effects, especially on hormone-related cancers, and these would be valuable for future clinical applications of EXD as an alternative regime for cancers." 07/01/2013 - "Erxian Decoction (EXD) is a well-documented Chinese medicinal formulation, which has been clinically applied for years for relieving menopausal syndromes by modulating hormonal levels indicating that EXD might also be effective in treating hormone-related tumors. "

Related Drugs and Biologics

1.	er-xian decoction
2.	Serotonin (5 Hydroxytryptamine)
3.	Estrogens (Estrogen)
4.	Hormones (Hormone)
5.	Cyclophosphamide (Cytoxan)
6.	Huang Qi
7.	benzoylamido- 4'- aminostilbene- 2,2'- disulfonate (BADS)
8.	Proteins (Proteins, Gene)
9.	Ointments (Pastes)
10.	Estradiol (Delestrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Electrodes (Electrode)