N-acetylneuraminoyllactose

Also Known As:

N-acetylneuramin lactose; N-acetylneuraminyl-2-3-lactose; N-acetylneuraminyllactose; acetylneuraminyllactose; neuraminlactose; sialyl(alpha2,3)lactose; sialyl-lactose; sialyllactose

Networked: 30 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hayashi, Yukiko K: 2 articles (10/2014 - 01/2012)
2.	Malicdan, May Christine V: 2 articles (10/2014 - 01/2012)
3.	Nishino, Ichizo: 2 articles (10/2014 - 01/2012)
4.	Noguchi, Satoru: 2 articles (10/2014 - 01/2012)
5.	Nonaka, Ikuya: 2 articles (10/2014 - 01/2012)
6.	Izquierdo-Useros, Nuria: 2 articles (07/2014 - 01/2012)
7.	Kräusslich, Hans-Georg: 2 articles (07/2014 - 01/2012)
8.	Lorizate, Maier: 2 articles (07/2014 - 01/2012)
9.	Martinez-Picado, Javier: 2 articles (07/2014 - 01/2012)
10.	Telenti, Amalio: 2 articles (07/2014 - 01/2012)

Related Diseases

1.	Muscular Diseases (Myopathy) 10/01/2014 - "Sialyllactose ameliorates myopathic phenotypes in symptomatic GNE myopathy model mice."
2.	Lung Neoplasms (Lung Cancer) 10/01/2022 - "The simplicity and effectiveness of the methodology are demonstrated on the model compound, sialyllactose, and its applicability for biological studies is presented on N-glycan profiling in the sera of lung cancer patients."
3.	Infections 03/01/2004 - "We produced a novel cationic-charged modified DNA aptamer for sialyllactose that is a ubiquitous component of the cell surface responsible for the infection of several viruses by using the magnetic-particle-based SELEX method. " 01/19/2001 - "Sialic acid binding was operant early during SA+ attachment, since the capacity of soluble sialyllactose to inhibit infection decreased rapidly during the first 20 min of adsorption. " 08/01/2003 - "Treatment of Helicobacter pylori infection using a novel antiadhesion compound (3'sialyllactose sodium salt). " 12/01/1997 - "Our results showed that sialyllactose, the first three sugar molecules of common oligosaccharides on the surface of mammalian cells, inhibits virus binding to the host cell and infection with the persistent BeAn virus but not the nonpersistent GDVII and chimera 39 viruses." 07/01/2014 - "In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. "
4.	Neoplasms (Cancer) 09/01/2015 - "When compared with the wild-type and single point mutant, the double point mutant exhibits enhanced affinity towards α(2,3)-linked sialyllactose, which can be effectively used as a model for biological cell marker in cancer therapeutics." 08/29/2017 - "Sialyllactose suppresses angiogenesis by inhibiting VEGFR-2 activation, and tumor progression." 01/01/1996 - "When lactose was used as acceptor, again lower enzyme activity in the tumor cells in comparison with that in liver was established, but in liver and in hepatoma cells the predominant 14C-labelled product of the sialyltransferase assay was alpha (2-6) sialyllactose isomer. " 01/01/2021 - "Representative structures of glycans with elevated levels in cancer patients included the following: small glycans related to sialyllactose; sialyl Lewis X; lactose- and N-acetyllactosamine (LacNAc) type-II-core glycans with LacNAc (type-I or II)-extensions and modifications of α1,3/4-fucose and/or 6-sulfate on the Glc/GlcNAc; free-N-glycans containing sialylation or β1,6-branch of 6-sulfo Lewis X; novel NeuAcα2-3Galβ1-4(+/-Fucα1-3) Xylα1-3Glc glycans. " 08/15/1997 - "RBC CA activity inhibition experiments reported here indicate that the domain NeuNAc alpha2-3Gal, as found in sialyllactose, synthetic sialyl(s) Lewis(Le)(x) and sLe(a), sialyllactosamine, sialyl-fucosyllactose, and nonfucosylated sLe(a), constitutes the minimal epitope for these CAs, implicating that these autoantibodies could be able to bind this domain in sLe(x) and sLe(a) and related carbohydrates expressed on nucleated cells and in soluble cancer-related mucins. "
5.	Human Influenza (Influenza) 07/01/2018 - "Furthermore, the concept is also proved by using human influenza viruses (H1N1, A/PR/8/34) and sugar chain (6'-sialyllactose)-modified probes. " 01/01/2022 - "Furthermore, we investigated the inhibition of the influenza HA glycoprotein association with the host mimetic surface by natural and synthetic sialic acid-based inhibitors (sialic acid, Siaα2,3-GalOMe, FB127, 3-sialyl lactose) using electrochemical impedance spectroscopy and observe that while all inhibit, they do not prevent host binding. " 08/15/2023 - "Synthesis of multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutinin." 05/14/2012 - "Further, immobilizing O-cyanate chain-end functionalized sialyllactose-containing glycopolymers onto amine-modified SPR chip via isourea bond formation afforded SPR-based glyco-biosensor, which showed specific binding activity for lectins and influenza viral hemagglutinins (HA). "

Related Drugs and Biologics

1.	Polysaccharides (Glycans)
2.	N-Acetylneuraminic Acid (Sialic Acid)
3.	Lactose
4.	Lectins
5.	Glycoproteins (Glycoprotein)
6.	Fetuins
7.	Sialic Acids
8.	Gangliosides
9.	Fucose
10.	Sialyl Lewis X Antigen

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics