Thalidomide FDA Link

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Also Known As:

Thalomid; Celgene Brand of Thalidomide; Sedoval; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-

Pharmalogical Action Categories:

Angiogenesis Inhibitors
Immunosuppressive Agents
Leprostatic Agents
Teratogens

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Phthalic Acids
      - Phthalimides: 6
        Thalidomide: 3480
Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - Piperidones: 2
      - Thalidomide: 3480
- 2-Ring Heterocyclic Compounds
  - Isoindoles
    - Phthalimides: 6
      - Thalidomide: 3480

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