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Lei Zhang Selected Research

15-hydroxy-5,8,11,13-eicosatetraenoic acid

8/2014NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia.
9/2013Placenta growth factor mediates angiogenesis in hypoxic pulmonary hypertension.
6/201315-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
1/2013Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
10/2012Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
1/201215-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway.
10/2011Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension.
11/2010Increased expression and altered subcellular distribution of PKC-δ and PKC-ɛ in pulmonary arteries exposed to hypoxia and 15-HETE.
9/2010Hypoxia suppresses Kv 2.1 channel expression through endogenous 15-hydroxyeicosatetraenoic acid in rat pulmonary artery.
8/201015-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90.
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Lei Zhang Research Topics

Disease

293Neoplasms (Cancer)
03/2016 - 02/2002
85Infection
01/2016 - 12/2004
57Inflammation
12/2015 - 10/2004
46Neoplasm Metastasis (Metastasis)
01/2016 - 08/2005
39Carcinoma (Carcinomatosis)
09/2015 - 03/2003
37Anoxia (Hypoxia)
12/2015 - 12/2004
35Body Weight (Weight, Body)
07/2015 - 10/2005
34Wounds and Injuries (Trauma)
06/2015 - 04/2004
31Myocardial Infarction
10/2015 - 03/2005
28Breast Neoplasms (Breast Cancer)
01/2016 - 12/2004
27Hepatocellular Carcinoma (Hepatoma)
12/2015 - 06/2002
26Obesity
07/2015 - 01/2005
25Fibrosis (Cirrhosis)
06/2015 - 05/2005
24Ischemia
06/2015 - 07/2005
22Thrombocytopenia (Thrombopenia)
11/2015 - 01/2005
21Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2016 - 02/2002
21Insulin Resistance
07/2015 - 09/2003
21Brain Ischemia (Cerebral Ischemia)
06/2015 - 10/2004
21Reperfusion Injury
04/2015 - 06/2007
20Pain (Aches)
09/2015 - 02/2003
18Thrombosis (Thrombus)
10/2015 - 09/2005
18Hemorrhage
09/2015 - 11/2005
16Glioma (Gliomas)
12/2015 - 12/2004
16Atherosclerosis
09/2014 - 02/2006
15Brain Injuries (Brain Injury)
11/2015 - 06/2004
15Contagious Ecthyma (Orf)
01/2014 - 08/2003
14Stomach Neoplasms (Stomach Cancer)
02/2016 - 11/2010
14Necrosis
06/2015 - 07/2005
13Lung Neoplasms (Lung Cancer)
12/2015 - 05/2005
13Stroke (Strokes)
10/2015 - 06/2003
13Hypertension (High Blood Pressure)
09/2015 - 06/2003
13Alzheimer Disease (Alzheimer's Disease)
05/2015 - 07/2009
12Melanoma (Melanoma, Malignant)
10/2015 - 01/2009
11Prostatic Neoplasms (Prostate Cancer)
11/2015 - 12/2005
11Pancreatic Neoplasms (Pancreatic Cancer)
05/2015 - 03/2009
11Leukemia
01/2015 - 09/2007
11Shock
01/2015 - 06/2007
10Glioblastoma (Glioblastoma Multiforme)
11/2015 - 12/2003
10Type 2 Diabetes Mellitus (MODY)
10/2015 - 03/2010
10Liver Cirrhosis (Hepatic Cirrhosis)
04/2015 - 02/2010
10Post-Traumatic Stress Disorders (PTSD)
01/2015 - 01/2008
10Cardiovascular Diseases (Cardiovascular Disease)
01/2015 - 06/2003
9Colorectal Neoplasms (Colorectal Cancer)
01/2016 - 11/2011
9Osteosarcoma (Osteogenic Sarcoma)
08/2015 - 07/2010
9Sarcoma (Soft Tissue Sarcoma)
06/2015 - 10/2010
9Lung Injury
06/2015 - 11/2005
9Rheumatoid Arthritis
03/2015 - 02/2008
9Experimental Arthritis
06/2014 - 02/2007
9Autoimmune Diseases (Autoimmune Disease)
01/2014 - 08/2006
9Pancreatitis
06/2013 - 01/2003
8Heart Failure
10/2015 - 01/2011
8Adenocarcinoma
06/2015 - 09/2004
8Schizophrenia (Dementia Praecox)
04/2015 - 08/2005

Drug/Important Bio-Agent (IBA)

58Messenger RNA (mRNA)IBA
10/2015 - 03/2002
44Biological Markers (Surrogate Marker)IBA
11/2015 - 11/2007
37Proteins (Proteins, Gene)IBA
12/2015 - 03/2005
33MicroRNAs (MicroRNA)IBA
09/2015 - 05/2012
31DNA (Deoxyribonucleic Acid)IBA
12/2015 - 08/2002
31Glucose (Dextrose)FDA LinkGeneric
04/2015 - 09/2003
25Inosine Triphosphate (ITP)IBA
11/2015 - 01/2005
22Carbon MonoxideIBA
12/2015 - 07/2005
22Insulin (Novolin)FDA Link
04/2015 - 09/2003
21Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2015 - 09/2003
21Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2015 - 12/2003
20CytokinesIBA
10/2015 - 12/2004
20Transcription Factors (Transcription Factor)IBA
10/2015 - 12/2003
20Complementary DNA (cDNA)IBA
07/2013 - 06/2002
19Phosphotransferases (Kinase)IBA
07/2015 - 02/2003
18AntigensIBA
07/2015 - 12/2003
15RNA (Ribonucleic Acid)IBA
12/2015 - 12/2004
14Interleukin-6 (Interleukin 6)IBA
12/2015 - 02/2005
13Small Interfering RNA (siRNA)IBA
02/2016 - 01/2008
13glucuronyl glucosamine glycan sulfate (Vessel)IBA
11/2015 - 09/2005
12CollagenIBA
06/2015 - 10/2005
12CholesterolIBA
01/2015 - 06/2003
1215-hydroxy-5,8,11,13-eicosatetraenoic acidIBA
08/2014 - 02/2009
11InterferonsIBA
12/2015 - 06/2011
11Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2015 - 11/2005
11Cisplatin (Platino)FDA LinkGeneric
08/2015 - 01/2005
11Hemoglobins (Hemoglobin)IBA
01/2015 - 08/2009
10Protein Kinases (Protein Kinase)IBA
11/2015 - 03/2006
9AntibodiesIBA
11/2015 - 08/2006
9salicylhydroxamic acid (SHAM)IBA
09/2015 - 10/2005
9Carrier Proteins (Binding Protein)IBA
01/2015 - 02/2006
9Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA
08/2014 - 08/2010
8Streptozocin (Streptozotocin)FDA Link
11/2015 - 03/2008
8Folic Acid (Vitamin M)FDA LinkGeneric
09/2015 - 09/2010
8OxygenIBA
07/2015 - 06/2006
8InterleukinsIBA
06/2015 - 01/2007
8Transforming Growth Factor beta (TGF-beta)IBA
01/2015 - 10/2005
8Amino AcidsFDA Link
11/2014 - 10/2003

Therapy/Procedure

38Drug Therapy (Chemotherapy)
01/2016 - 12/2005
32Transplantation (Transplant Recipients)
07/2015 - 02/2002
18Heterologous Transplantation (Xenotransplantation)
01/2016 - 07/2005
15Stents
10/2015 - 12/2007
13Transplants (Transplant)
05/2015 - 01/2005
12Chinese Traditional Medicine (Traditional Chinese Medicine)
10/2015 - 07/2009
12Aftercare (After-Treatment)
03/2015 - 09/2008
11Kidney Transplantation
05/2015 - 06/2009
8Radiotherapy
03/2015 - 12/2005