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Moussa B H Youdim Selected Research

rasagiline (Azilect)

9/2015Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice.
3/2013Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline.
8/2012Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
1/2012I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.
1/2012From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease.
1/2011Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease.
12/2010Site-activated chelators derived from anti-Parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease.
11/2010Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.
3/2010The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline.
2/2010Rasagiline in Parkinson's disease.
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Moussa B H Youdim Research Topics

Disease

66Parkinson Disease (Parkinson's Disease)
03/2015 - 01/2002
50Neurodegenerative Diseases (Neurodegenerative Disease)
09/2015 - 01/2002
38Alzheimer Disease (Alzheimer's Disease)
09/2015 - 03/2002
27Neuroblastoma
05/2012 - 01/2002
16Parkinsonian Disorders (Parkinsonism)
01/2012 - 08/2002
15Dementia (Dementias)
03/2013 - 03/2002
14Anoxia (Hypoxia)
01/2015 - 01/2005
8Inflammation
01/2012 - 08/2004
7Lewy Body Disease (Lewy Body Dementia)
09/2011 - 05/2003
6Pheochromocytoma
01/2012 - 01/2002
5Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2012 - 03/2004
4Neoplasms (Cancer)
04/2013 - 09/2008
4Ischemia
03/2013 - 01/2005
4Schizophrenia (Dementia Praecox)
04/2012 - 06/2006
4Disease Progression
09/2011 - 01/2003
4Nervous System Diseases (Neurological Disorders)
10/2008 - 03/2004
4Huntington Disease (Huntington's Disease)
09/2007 - 03/2004
4Friedreich Ataxia (Friedreich's Ataxia)
02/2006 - 02/2004
3Craniocerebral Trauma (Head Injury)
06/2005 - 01/2005
2Memory Disorders (Memory Loss)
09/2015 - 09/2012
2Brain Ischemia (Cerebral Ischemia)
12/2013 - 03/2004
2Basal Ganglia Diseases (Basal Ganglia Disease)
04/2012 - 01/2011
2Shock
01/2012 - 08/2007
2Diabetes Mellitus
06/2010 - 11/2009
2Glioblastoma (Glioblastoma Multiforme)
05/2010 - 04/2009
2MPTP Poisoning
01/2010 - 01/2007
2Starvation
11/2009 - 09/2008
2Nerve Degeneration
12/2007 - 01/2004
2Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease)
02/2006 - 02/2004

Drug/Important Bio-Agent (IBA)

52IronIBA
09/2015 - 01/2002
40rasagiline (Azilect)FDA Link
09/2015 - 04/2002
35Monoamine Oxidase (MAO)IBA
03/2015 - 04/2002
19(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA
03/2013 - 03/2002
17TeaIBA
12/2012 - 01/2002
16Chelating AgentsIBA
09/2015 - 03/2004
13Dopamine (Intropin)FDA LinkGeneric
03/2015 - 06/2002
13Amyloid (Amyloid Fibrils)IBA
09/2012 - 08/2002
121- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
03/2015 - 10/2002
12Cholinesterases (Cholinesterase)IBA
03/2013 - 10/2002
10Neuroprotective AgentsIBA
03/2013 - 01/2003
10polyphenolsIBA
12/2012 - 01/2002
10Reactive Oxygen Species (Oxygen Radicals)IBA
12/2009 - 03/2004
9propargylamineIBA
06/2014 - 04/2005
9Proteins (Proteins, Gene)IBA
04/2013 - 04/2003
8Oxidopamine (6 Hydroxydopamine)IBA
03/2015 - 01/2002
8Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
06/2014 - 10/2004
8N-propargylIBA
08/2012 - 04/2002
7AntioxidantsIBA
01/2012 - 05/2003
7UbiquitinIBA
01/2012 - 08/2004
7Selegiline (E250)FDA LinkGeneric
01/2010 - 04/2002
6Complementary DNA (cDNA)IBA
12/2004 - 10/2002
5Oxyquinoline (8 Hydroxyquinoline)FDA Link
06/2014 - 01/2010
5Serotonin (5 Hydroxytryptamine)IBA
04/2012 - 02/2005
5Proteasome Endopeptidase Complex (Proteasome)IBA
11/2009 - 08/2004
4methyl carbamateIBA
04/2012 - 10/2002
4Antipsychotic Agents (Antipsychotics)IBA
04/2012 - 06/2006
4Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2012 - 11/2009
4Levodopa (L Dopa)FDA LinkGeneric
11/2010 - 01/2005
4Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
11/2009 - 01/2008
4NeurotoxinsIBA
11/2009 - 01/2005
4Catechin (Z 7300)IBA
10/2008 - 08/2004
4(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA
06/2004 - 10/2002
3Insulin (Novolin)FDA Link
02/2014 - 11/2009
3LithiumIBA
04/2013 - 06/2004
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2013 - 11/2009
3Peroxynitrous Acid (Peroxynitrite)IBA
03/2013 - 11/2007
3Brain-Derived Neurotrophic Factor (BDNF)IBA
03/2013 - 08/2005
3Antidepressive Agents (Antidepressants)IBA
04/2012 - 03/2002
3Carbon MonoxideIBA
04/2012 - 07/2003
3Biological Markers (Surrogate Marker)IBA
01/2012 - 01/2007
3FlavonoidsIBA
01/2012 - 08/2007
3Messenger RNA (mRNA)IBA
02/2009 - 08/2005
3Caspase 3 (Caspase-3)IBA
09/2008 - 01/2007
3neuromelaninIBA
01/2004 - 01/2003
2Ethanol (Ethyl Alcohol)IBA
01/2015 - 05/2010
2Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
01/2014 - 08/2007
21-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA
01/2014 - 11/2009
2ErythropoietinFDA Link
03/2013 - 01/2012
2Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
03/2013 - 01/2012
2Nerve Growth Factors (Neurotrophins)IBA
03/2013 - 01/2012
2butyrylesteraseIBA
03/2013 - 12/2006
2Free RadicalsIBA
01/2012 - 01/2011
2Aldehyde DehydrogenaseIBA
01/2012 - 08/2005
2lactacystinIBA
03/2011 - 12/2007
2rivastigmine (Exelon)FDA LinkGeneric
01/2010 - 10/2006
2Dexamethasone (Maxidex)FDA LinkGeneric
01/2010 - 04/2009
2epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2010 - 08/2007
2CatalaseIBA
02/2009 - 09/2008
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
02/2008 - 08/2002
23-morpholino-sydnonimine (SIN 1)IBA
11/2007 - 10/2003
2Apoptosis Regulatory ProteinsIBA
09/2007 - 01/2007
2OxygenIBA
08/2007 - 08/2005
2Familial apoceruloplasmin deficiencyIBA
02/2006 - 02/2004
2Phosphotransferases (Kinase)IBA
06/2004 - 10/2003
2gallocatechol (epigallocatechin)IBA
03/2004 - 08/2002
2alpha-SynucleinIBA
03/2004 - 01/2004
2salsolineIBA
10/2003 - 08/2002
2Conditioned Culture MediaIBA
05/2003 - 08/2002
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2015

Therapy/Procedure

2Therapeutics
05/2011 - 02/2008