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Mark A Yorek Selected Research

Streptozocin (Streptozotocin)

1/2021Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats.
1/2021Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.
1/2020Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes.
1/2020Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment.
9/2018Determination of peripheral neuropathy in high-fat diet fed low-dose streptozotocin-treated female C57Bl/6J mice and Sprague-Dawley rats.
4/2017Effect of tempol on peripheral neuropathy in diet-induced obese and high-fat fed/low-dose streptozotocin-treated C57Bl6/J mice.
1/2017Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.
1/2017Effect of Fish Oil vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy.
1/2016Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints.
1/2016Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
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Mark A Yorek Research Topics

Disease

25Peripheral Nervous System Diseases (PNS Diseases)
01/2021 - 12/2007
22Type 2 Diabetes Mellitus (MODY)
01/2021 - 01/2008
22Diabetic Neuropathies (Diabetic Neuropathy)
01/2021 - 12/2005
13Hyperglycemia
01/2020 - 01/2003
7Obesity
01/2021 - 01/2011
6Diabetes Complications
08/2013 - 02/2002
5Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2016 - 03/2008
3Body Weight (Weight, Body)
01/2020 - 01/2016
3Cardiovascular Diseases (Cardiovascular Disease)
02/2015 - 02/2006
2Prediabetic State (Prediabetes)
01/2020 - 01/2016
2Mitochondrial Diseases (Mitochondrial Disease)
06/2017 - 11/2014
2Insulin Resistance
01/2016 - 10/2011
2Weight Gain
01/2016 - 01/2016
2Weight Loss (Weight Reduction)
01/2015 - 12/2011
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2009 - 01/2008
2Pancreatitis
07/2006 - 01/2004
1Atrophy
01/2022
1Neuralgia (Stump Neuralgia)
01/2021
1Neuroblastoma
01/2021
1Polyneuropathies (Polyneuropathy)
01/2021
1Dyslipidemias (Dyslipidemia)
01/2020
1Disease Progression
01/2020
1Fatty Liver
01/2012
1Glucose Intolerance
01/2011
1Experimental Diabetes Mellitus
01/2011
1Hypertension (High Blood Pressure)
03/2008

Drug/Important Bio-Agent (IBA)

25Streptozocin (Streptozotocin)FDA Link
01/2021 - 01/2003
13Menhaden oilIBA
01/2021 - 01/2012
9Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
10/2015 - 01/2008
7Neprilysin (Neutral Endopeptidase)IBA
01/2018 - 01/2009
6Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2021 - 07/2015
6Fish OilsIBA
01/2020 - 07/2015
6EnalaprilFDA LinkGeneric
06/2017 - 01/2008
6Glucose (Dextrose)FDA LinkGeneric
06/2017 - 02/2002
6AVE 7688IBA
12/2012 - 01/2009
4Blood Glucose (Blood Sugar)IBA
01/2020 - 09/2014
4Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2020 - 01/2012
4resolvin D1IBA
01/2018 - 07/2015
4Pharmaceutical PreparationsIBA
01/2018 - 01/2009
3LipidsIBA
01/2018 - 01/2008
3Thioctic Acid (Lipoic Acid)IBA
06/2017 - 10/2015
3AntioxidantsIBA
10/2015 - 01/2008
3Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
10/2015 - 02/2006
3Vasopeptidase InhibitorsIBA
12/2012 - 01/2008
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
06/2006 - 01/2005
2NAD (NADH)IBA
01/2021 - 01/2020
2Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA
01/2021 - 08/2013
2Insulin (Novolin)FDA Link
01/2020 - 09/2014
2salicylsalicylic acid (salsalate)IBA
01/2018 - 01/2016
2Angiotensin Receptor AntagonistsIBA
01/2018 - 02/2006
2candoxatrilIBA
11/2016 - 01/2011
2Peroxynitrous Acid (Peroxynitrite)IBA
11/2014 - 12/2007
2Superoxides (Superoxide)IBA
11/2014 - 01/2005
2Proteins (Proteins, Gene)FDA Link
11/2014 - 01/2004
2Acetylcholine (Acetylcholine Chloride)FDA Link
10/2011 - 01/2003
2Angiotensin Receptors (Angiotensin II Receptor)IBA
01/2008 - 02/2006
2NF-kappa B (NF-kB)IBA
07/2006 - 01/2004
1Activating Transcription Factor 4IBA
01/2022
1Pyruvaldehyde (Methylglyoxal)IBA
01/2021
1Neuroprotective AgentsIBA
01/2021
1mitoquinoneIBA
01/2021
1MagnesiumIBA
01/2021
1Fatty Acids (Saturated Fatty Acids)IBA
01/2018
1Docosahexaenoic AcidsIBA
01/2018
1Unsaturated Dietary FatsIBA
01/2018
1Dietary Fats (Dietary Fat)IBA
01/2018
1sacubitril and valsartan sodium hydrate drug combinationIBA
01/2018
1Pyruvate KinaseIBA
06/2017
1Messenger RNA (mRNA)IBA
06/2017
1ML-265IBA
06/2017
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2017
1tempolIBA
04/2017
1EstersIBA
01/2017
1Nonesterified Fatty Acids (NEFA)IBA
01/2016
1nicotinamide-beta-ribosideIBA
01/2016
1CholesterolIBA
01/2016
1NADP (NADPH)IBA
01/2016
1Ophthalmic Solutions (Eye Drops)IBA
01/2016
1Triglycerides (Triacylglycerol)IBA
01/2016
1Biomarkers (Surrogate Marker)IBA
01/2016
1Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2014
1EnzymesIBA
11/2014
1Mitogen-Activated Protein KinasesIBA
08/2013
1Sodium-Hydrogen Exchanger 1IBA
08/2013
1Sodium-Hydrogen ExchangersIBA
08/2013
1Lipoxygenase InhibitorsIBA
08/2013
1AcidsIBA
01/2012
1AdiponectinIBA
01/2012
1lardIBA
01/2012
1baicaleinIBA
12/2011
1Calcitonin Gene-Related PeptideIBA
10/2011
1Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
01/2011
1SodiumIBA
03/2008
1AngiotensinsIBA
03/2008

Therapy/Procedure

2Glycemic Control
01/2020 - 09/2014
2Therapeutics
01/2017 - 10/2015
2Injections
01/2017 - 07/2015
2Ligation
07/2006 - 01/2004
1Aftercare (After-Treatment)
01/2020
1Caloric Restriction
12/2011