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Takehiko Yokomizo Selected Research

Leukotriene B4

1/2023Deficiency of leukotriene B4 receptor type 1 ameliorates ovalbumin-induced allergic enteritis in mice.
1/2023The leukotriene B4 /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis.
1/2022Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice.
10/2020Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
1/2020Leukotriene B4 receptors as therapeutic targets for ophthalmic diseases.
1/2020The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
1/2019An Alternative Pathway to Leukotriene B4 Enantiomers Involving a 1,8-Diol-Forming Reaction of an Algal Oxylipin.
1/2019The leukotriene receptors as therapeutic targets of inflammatory diseases.
1/2018Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4.
1/2018Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.
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Takehiko Yokomizo Research Topics

Disease

30Inflammation (Inflammations)
01/2023 - 08/2002
7Asthma (Bronchial Asthma)
01/2023 - 10/2005
6Neoplasms (Cancer)
01/2018 - 12/2005
5Wounds and Injuries (Trauma)
03/2023 - 06/2014
4Fibrosis (Cirrhosis)
01/2023 - 05/2006
4Sepsis (Septicemia)
10/2021 - 01/2017
4Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
01/2020 - 01/2019
3Reperfusion Injury
02/2024 - 08/2013
3Macular Degeneration (Age-Related Maculopathy)
01/2023 - 02/2015
3Psoriasis (Pustulosis Palmaris et Plantaris)
01/2023 - 03/2014
3Pain (Aches)
01/2022 - 03/2015
3Hypersensitivity (Allergy)
01/2021 - 06/2010
3Insulin Resistance
01/2020 - 06/2003
3Atopic Dermatitis (Atopic Eczema)
07/2019 - 01/2019
3Colitis
01/2018 - 12/2010
3Leukemia
01/2018 - 11/2002
2Neuroinflammatory Diseases
12/2023 - 12/2014
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2023 - 04/2010
2Allergic Contact Dermatitis
01/2023 - 01/2021
2Immune System Diseases (Immune Disorders)
01/2023 - 10/2005
2Glomerulonephritis
01/2023 - 01/2023
2Ischemia
12/2021 - 08/2013
2Obesity
10/2020 - 06/2003
2Allergic Rhinitis
07/2019 - 01/2018
2Anaphylaxis (Anaphylactic Shock)
07/2019 - 10/2016
2Ureteral Obstruction
01/2019 - 01/2019
2Eosinophilia
08/2013 - 03/2013
1Dry Eye Syndromes (Dry Eye Syndrome)
03/2024
1Ischemic Stroke
02/2024
1Neurologic Manifestations (Neurological Manifestations)
12/2023
1Multiple Sclerosis
12/2023
1Disease Progression
08/2023
1Patent Ductus Arteriosus
08/2023
1Bipolar Disorder (Manic Depressive Psychosis)
07/2023
1Mood Disorders (Mood Disorder)
07/2023
1Conjunctivitis
01/2023
1Hyperplasia
01/2023
1Food Hypersensitivity (Food Allergy)
01/2023
1Enteritis
01/2023
1Dermatitis
01/2022
1Nociceptive Pain
01/2022

Drug/Important Bio-Agent (IBA)

26Leukotriene B4IBA
01/2023 - 08/2002
18Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA
01/2023 - 10/2005
14LipidsIBA
01/2023 - 09/2005
6G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
02/2024 - 10/2004
6CytokinesIBA
01/2023 - 06/2010
5LeukotrienesIBA
07/2019 - 12/2015
4EnzymesIBA
07/2023 - 11/2002
4Fatty Acids (Saturated Fatty Acids)IBA
12/2021 - 01/2018
3Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
01/2020 - 01/2019
3AcidsIBA
01/2019 - 03/2013
312-hydroxy-5,8,10-heptadecatrienoic acidIBA
10/2017 - 06/2014
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 05/2006
2Ophthalmic Solutions (Eye Drops)IBA
03/2024 - 10/2017
2Fingolimod Hydrochloride (FTY720)FDA Link
12/2023 - 12/2014
2ProstaglandinsIBA
08/2023 - 01/2021
2Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
07/2023 - 12/2021
2Eicosapentaenoic AcidIBA
07/2023 - 01/2019
2Chemotactic FactorsIBA
01/2023 - 01/2015
2OvalbuminIBA
01/2023 - 08/2013
2Antigen-Antibody Complex (Immune Complex)IBA
01/2023 - 01/2023
2Formaldehyde (Formol)FDA Link
01/2022 - 03/2015
2Phospholipids (Phosphatides)FDA LinkGeneric
12/2021 - 01/2018
2EicosanoidsIBA
09/2021 - 11/2020
2Indomethacin (Indometacin)FDA LinkGeneric
01/2021 - 01/2020
2AntigensIBA
01/2021 - 10/2012
2AllergensIBA
01/2021 - 03/2013
2PapaverineIBA
12/2020 - 01/2019
2Receptor for Advanced Glycation End ProductsIBA
12/2020 - 01/2019
2Irinotecan (Camptosar)FDA LinkGeneric
11/2020 - 01/2018
2Anesthetics (Anesthetic Agents)IBA
11/2019 - 01/2017
2Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
07/2019 - 06/2014
2Messenger RNA (mRNA)IBA
01/2018 - 08/2013
2Dextran SulfateIBA
01/2018 - 02/2015
2Carrier Proteins (Binding Protein)IBA
12/2016 - 01/2016
2CalciumIBA
01/2016 - 08/2008
2LipopolysaccharidesIBA
12/2015 - 12/2009
1Cyclosporine (Ciclosporin)FDA LinkGeneric
03/2024
1diquafosolIBA
03/2024
1Fluorescein (Funduscein)FDA LinkGeneric
03/2024
1Bicarbonates (Hydrogen Carbonate)IBA
02/2024
1Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
12/2023
1Transcobalamins (Transcobalamin II)IBA
12/2023
1VitaminsIBA
12/2023
1Fatty Acid DesaturasesIBA
07/2023
1Docosahexaenoic AcidsIBA
07/2023
1SW033291IBA
03/2023
1Peroxidase (Myeloperoxidase)IBA
01/2023
1PotassiumIBA
01/2023
1Immunoglobulin E (IgE)IBA
01/2023
1Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
01/2023
1AluminumIBA
01/2023
1Imiquimod (Aldara)FDA LinkGeneric
01/2022
1Liver X ReceptorsIBA
01/2022
1CreatinineIBA
12/2021
1Soybean OilFDA LinkGeneric
12/2021
1Urea (Carbamide)FDA LinkGeneric
12/2021

Therapy/Procedure

4Ligation
11/2019 - 01/2016
3Punctures
11/2019 - 01/2017
1Investigational Therapies (Experimental Therapy)
02/2024