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Bo Yang Selected Research

tirapazamine (SR 4233)

3/2014Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α.
3/2011Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
1/2010Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.
5/2007Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
8/2006Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
4/2005Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.
4/2003Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.

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Bo Yang Research Topics

Disease

133Neoplasms (Cancer)
11/2015 - 01/2002
28Neoplasm Metastasis (Metastasis)
11/2015 - 03/2002
25Anoxia (Hypoxia)
11/2014 - 04/2003
19Infection
12/2015 - 11/2002
17Lung Neoplasms (Lung Cancer)
11/2015 - 01/2010
15Breast Neoplasms (Breast Cancer)
12/2015 - 05/2007
13Leukemia
02/2015 - 08/2006
11Atrial Fibrillation
11/2015 - 01/2006
11Colonic Neoplasms (Colon Cancer)
10/2015 - 01/2010
11Hepatocellular Carcinoma (Hepatoma)
03/2014 - 01/2007
10Heart Failure
08/2015 - 06/2004
10Carcinoma (Carcinomatosis)
01/2015 - 08/2005
10Prostatic Neoplasms (Prostate Cancer)
01/2015 - 07/2005
10Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/2014 - 10/2010
9Fibrosis (Cirrhosis)
12/2015 - 04/2006
9Inflammation
10/2015 - 01/2004
9Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2015 - 04/2004
9Colorectal Neoplasms (Colorectal Cancer)
05/2015 - 03/2002
8Myocardial Infarction
08/2015 - 01/2007
8Stroke (Strokes)
07/2015 - 02/2009
8Reperfusion Injury
01/2015 - 11/2007
8Hemorrhage
12/2014 - 08/2010
8Neuroblastoma
01/2011 - 04/2003
7Pancreatic Neoplasms (Pancreatic Cancer)
11/2015 - 05/2002
7Glioma (Gliomas)
04/2015 - 03/2011
6Insulin Resistance
06/2015 - 10/2007
6BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2015 - 04/2011
6Hypertension (High Blood Pressure)
04/2015 - 06/2005
6Ischemia
03/2015 - 11/2007
6Myelodysplastic Syndromes (Myelodysplastic Syndrome)
07/2014 - 07/2009
6Hypercholesterolemia
11/2008 - 11/2002
5Melanoma (Melanoma, Malignant)
11/2015 - 12/2008
5Cardiac Arrhythmias (Arrythmia)
11/2015 - 01/2006
5Wounds and Injuries (Trauma)
01/2014 - 06/2009
5Lymphoma (Lymphomas)
02/2013 - 07/2006
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
06/2012 - 10/2006
4Fragile X Syndrome (Martin Bell Syndrome)
08/2015 - 11/2013
4Mental Retardation (Idiocy)
08/2015 - 11/2013
4Infarction
08/2015 - 12/2004
4Renal Insufficiency (Renal Failure)
07/2015 - 03/2009
4Atherosclerosis
12/2014 - 11/2011
4Ovarian Neoplasms (Ovarian Cancer)
11/2014 - 02/2004
4Stomach Neoplasms (Stomach Cancer)
10/2013 - 08/2011
4Myocardial Ischemia (Ischemic Heart Diseases)
06/2013 - 10/2008
4Sleep Initiation and Maintenance Disorders (Insomnia)
02/2012 - 06/2010
3Brain Injuries (Brain Injury)
07/2015 - 10/2008

Drug/Important Bio-Agent (IBA)

20Messenger RNA (mRNA)IBA
12/2015 - 12/2003
12Proteins (Proteins, Gene)IBA
12/2015 - 06/2006
12MicroRNAs (MicroRNA)IBA
05/2015 - 02/2012
11Caspase 3 (Caspase-3)IBA
11/2014 - 01/2007
10DNA (Deoxyribonucleic Acid)IBA
12/2015 - 04/2006
10Tretinoin (Retinoic Acid)FDA LinkGeneric
07/2014 - 01/2007
8Interleukin-2 (IL2)IBA
02/2014 - 07/2008
7Small Interfering RNA (siRNA)IBA
10/2015 - 01/2010
7CytokinesIBA
10/2015 - 10/2008
7Biological Markers (Surrogate Marker)IBA
07/2015 - 10/2010
7tirapazamine (SR 4233)IBA
03/2014 - 04/2003
7Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2013 - 07/2007
7ezetimibe (Zetia)FDA Link
11/2008 - 11/2002
6Proteasome Endopeptidase Complex (Proteasome)IBA
06/2015 - 12/2010
6P-GlycoproteinIBA
06/2015 - 07/2008
6CalciumIBA
01/2015 - 12/2004
6Insulin (Novolin)FDA Link
10/2013 - 06/2005
6Glucose (Dextrose)FDA LinkGeneric
01/2013 - 02/2002
5Transcription Factors (Transcription Factor)IBA
12/2015 - 01/2008
5RNA (Ribonucleic Acid)IBA
11/2015 - 08/2003
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2015 - 01/2004
5FenretinideIBA
10/2014 - 10/2006
5tripterineIBA
10/2014 - 01/2010
5Cadherins (E-Cadherin)IBA
10/2014 - 10/2010
5salicylhydroxamic acid (SHAM)IBA
09/2014 - 10/2008
5Carbon MonoxideIBA
06/2014 - 08/2004
5combretastatin A-4 (combretastatin A4)IBA
01/2014 - 03/2008
5Simvastatin (Zocor)FDA LinkGeneric
01/2014 - 12/2003
5bortezomib (Velcade)FDA Link
01/2014 - 03/2010
5NitrogenIBA
06/2012 - 04/2006
4CytosineIBA
08/2015 - 11/2013
4imatinib (Gleevec)FDA Link
06/2015 - 12/2012
4UbiquitinIBA
04/2015 - 12/2010
4dasatinib (BMS 354825)FDA Link
03/2015 - 06/2012
4Cisplatin (Platino)FDA LinkGeneric
11/2014 - 02/2004
4Histone Deacetylases (Histone Deacetylase)IBA
10/2014 - 03/2011
4Reactive Oxygen Species (Oxygen Radicals)IBA
06/2014 - 11/2007
4Cyclin D1IBA
06/2014 - 12/2005
4Protein Kinases (Protein Kinase)IBA
01/2013 - 12/2008
4Etoposide (VP 16)FDA LinkGeneric
10/2011 - 09/2003
3InterferonsIBA
11/2015 - 01/2010
3cryptotanshinoneIBA
11/2015 - 03/2015
3docetaxel (Taxotere)FDA Link
10/2015 - 09/2007

Therapy/Procedure

28Drug Therapy (Chemotherapy)
08/2015 - 01/2002
27Heterologous Transplantation (Xenotransplantation)
05/2015 - 12/2005
12Transplantation (Transplant Recipients)
07/2015 - 07/2006
7Aftercare (After-Treatment)
10/2013 - 02/2007
6Radiotherapy
08/2014 - 03/2008
6Therapeutics
05/2014 - 12/2009
5Immunotherapy
02/2014 - 05/2005
5Nephrectomy
01/2014 - 09/2007
5Resuscitation
06/2012 - 04/2006
3Blood Transfusion (Blood Transfusions)
08/2015 - 06/2011
3Tracheostomy
07/2015 - 07/2014