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S Betty Yan Selected Research

drotrecogin alfa activated (Xigris)

6/2010Troponin-I as a prognosticator of mortality in severe sepsis patients.
11/2007Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever.
6/2007Effect of recombinant human activated protein C on the bactericidal activity of human monocytes and modulation of pro-inflammatory cytokines in the presence of antimicrobial agents.
8/2005Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies.
1/2005New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated).
5/2004Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling.
5/2004Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis.
5/2004Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C.
10/2003Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis.
7/2003Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated).

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S Betty Yan Research Topics

Disease

15Sepsis (Septicemia)
06/2010 - 05/2002
6Inflammation (Inflammations)
01/2005 - 05/2002
5Neoplasms (Cancer)
01/2018 - 08/2013
3Infections
06/2007 - 05/2004
2Neoplasm Metastasis (Metastasis)
12/2014 - 10/2013
2Purpura Fulminans
08/2005 - 05/2004
2Hemorrhage
05/2004 - 05/2004
2Endotoxemia
05/2004 - 11/2003
1Lung Neoplasms (Lung Cancer)
01/2018
1Circulating Neoplastic Cells
01/2017
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2013
1Fever (Fevers)
11/2007
1Ebola Hemorrhagic Fever
11/2007
1Escherichia coli Infections
06/2007
1Meningitis
08/2005
1Meningococcal Infections
08/2005
1Out-of-Hospital Cardiac Arrest
07/2005
1Heart Arrest (Cardiac Arrest)
07/2005
1Virus Diseases (Viral Diseases)
09/2004
1Dengue (Dengue Fever)
09/2004

Drug/Important Bio-Agent (IBA)

14Protein CIBA
06/2010 - 05/2002
10drotrecogin alfa activated (Xigris)FDA Link
06/2010 - 07/2003
5Biomarkers (Surrogate Marker)IBA
01/2017 - 07/2003
3merestinibIBA
01/2018 - 08/2013
2emibetuzumabIBA
01/2018 - 12/2014
2Phosphotransferases (Kinase)IBA
01/2018 - 08/2013
2CytokinesIBA
06/2007 - 09/2004
2AnticoagulantsIBA
07/2005 - 05/2002
2ThrombomodulinIBA
07/2005 - 05/2002
2factor V LeidenIBA
05/2004 - 11/2003
1Etoposide (VP 16)FDA LinkGeneric
01/2017
1CXC ChemokinesIBA
01/2017
1Peptides (Polypeptides)IBA
01/2017
1Carboplatin (JM8)FDA LinkGeneric
01/2017
1LY2510924IBA
01/2017
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
12/2014
1Cisplatin (Platino)FDA LinkGeneric
10/2013
1GemcitabineFDA Link
10/2013
1Erlotinib Hydrochloride (CP 358,774)FDA Link
10/2013
1LigandsIBA
08/2013
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
08/2013
1Adenosine Triphosphate (ATP)IBA
08/2013
1Oncogene Proteins (Oncogene Protein)IBA
08/2013
1c-Mer Tyrosine KinaseIBA
08/2013
1tyrosine receptor (receptor, tyrosine)IBA
08/2013
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2013
1Troponin IIBA
06/2010
1Levofloxacin (Levaquin)FDA Link
06/2007
1Anti-Bacterial Agents (Antibiotics)IBA
06/2007
1Ampicillin (Omnipen)FDA LinkGeneric
06/2007
1rho-Associated KinasesIBA
05/2004
1fibrin fragment D (D-dimer)IBA
05/2004
1Fibrinogen (Factor I)FDA Link
05/2002
1ThrombinFDA Link
05/2002

Therapy/Procedure

4Therapeutics
11/2007 - 07/2003
1Duration of Therapy
01/2018
1Resuscitation
07/2005
1Cardiopulmonary Resuscitation (CPR)
07/2005