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Hisashi Yamanaka Selected Research

Rheumatoid Arthritis

1/2016	The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.
1/2016	Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial.
12/2015	Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.
11/2015	Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis.
10/2015	Sustainable Efficacy of Switching From Intravenous to Subcutaneous Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis.
9/2015	Postoperative complications in patients with rheumatoid arthritis using a biological agent - A systematic review and meta-analysis.
7/2015	Cost-effectiveness of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, versus methotrexate in patients with rheumatoid arthritis using real-world data from the IORRA observational cohort study.
7/2015	Trend of patient characteristics and its impact on the response to adalimumab in patients with rheumatoid arthritis: post hoc time-course analysis of an all-case PMS in Japan.
7/2015	Efficacy and safety of tofacitinib as monotherapy in Japanese patients with active rheumatoid arthritis: a 12-week, randomized, phase 2 study.
7/2015	Assessment of the effectiveness of golimumab 50-mg and 100-mg regimens in patients with rheumatoid arthritis in daily practice.

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Hisashi Yamanaka Research Topics

Disease

107	Rheumatoid Arthritis 01/2016 - 04/2002
12	Gout 09/2015 - 06/2010
11	Hyperuricemia 09/2015 - 01/2003
11	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2013 - 01/2010
10	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2015 - 07/2010
10	Dermatomyositis (Dermatopolymyositis) 01/2014 - 07/2010
8	Pain (Aches) 01/2016 - 12/2005
8	Infection 09/2015 - 01/2007
5	Systemic Scleroderma (Systemic Sclerosis) 12/2015 - 05/2011
4	Drug Toxicity (Drug Safety) 07/2015 - 12/2002
4	Melanoma (Melanoma, Malignant) 12/2014 - 04/2011
3	Fibrosis (Cirrhosis) 12/2015 - 09/2010
3	Takayasu Arteritis (Arteritis, Takayasu's) 05/2015 - 08/2013
3	Myositis (Idiopathic Inflammatory Myopathies) 12/2014 - 07/2012
3	Autoimmune Diseases (Autoimmune Disease) 10/2012 - 07/2008
3	Pneumonia (Pneumonitis) 10/2011 - 06/2010
3	Inflammation 10/2010 - 06/2003
2	Lung Diseases (Lung Disease) 05/2014 - 12/2011
2	Arthritis (Polyarthritis) 04/2014 - 01/2010
2	Psoriasis (Pustulosis Palmaris et Plantaris) 08/2013 - 08/2012
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/2013 - 08/2012
2	Optic Neuritis (Retrobulbar Neuritis) 09/2012 - 04/2011
2	Hypertension (High Blood Pressure) 07/2012 - 11/2010
2	Nephritis 08/2011 - 10/2010
2	Osteoporosis 08/2011 - 03/2009
2	Rheumatic Diseases (Rheumatism) 01/2008 - 01/2007
2	Gouty Arthritis 06/2004 - 09/2002
1	Herpes Zoster 07/2015
1	Ulcerative Colitis 05/2015
1	Pulmonary Fibrosis (Hamman Rich Syndrome) 01/2015
1	Abdominal Pain (Pain, Abdominal) 01/2015
1	Systemic Vasculitis 01/2015
1	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2015
1	Idiopathic Pulmonary Fibrosis 01/2015
1	Microscopic Polyangiitis 01/2015
1	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis) 07/2014
1	Diabetes Mellitus 05/2014
1	Adult-Onset Still's Disease 04/2014
1	Radius Fractures (Radius Fracture) 04/2014
1	Fistula 01/2014
1	Crohn Disease (Crohn's Disease) 01/2014
1	T-Cell Leukemia (Leukemia, T Cell) 01/2014

Drug/Important Bio-Agent (IBA)

21	Methotrexate (Mexate)FDA LinkGeneric 01/2016 - 04/2002
13	Uric Acid (Urate)IBA 09/2015 - 09/2002
11	Antirheumatic Agents (DMARD)IBA 09/2015 - 12/2002
10	tocilizumab FDA Link 10/2015 - 04/2011
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2015 - 01/2006
9	TNFR-Fc fusion protein (etanercept)FDA Link 10/2013 - 01/2006
8	adalimumab (Humira)FDA Link 07/2015 - 04/2011
7	ametantrone (HAQ)IBA 01/2016 - 12/2005
7	AntibodiesIBA 05/2015 - 08/2011
6	Interleukin-6 (Interleukin 6)IBA 01/2016 - 10/2009
6	CDP870 FDA Link 01/2016 - 07/2014
6	infliximab (Remicade)FDA Link 11/2015 - 01/2007
6	febuxostat FDA Link 09/2015 - 06/2011
6	HLA-DRB1 antigen (HLA DRB1)IBA 05/2015 - 12/2011
6	AutoantibodiesIBA 01/2013 - 06/2011
5	Rheumatoid FactorIBA 12/2015 - 01/2007
5	Prednisolone (Predate)FDA LinkGeneric 07/2015 - 06/2011
5	Carbon MonoxideIBA 05/2015 - 06/2003
5	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 01/2009
5	Xanthine OxidaseIBA 06/2011 - 06/2011
5	purineIBA 06/2011 - 03/2011
4	CytokinesIBA 12/2014 - 07/2008
4	Interleukin-18 (Interleukin 18)IBA 04/2014 - 10/2010
4	Ferritins (Ferritin)IBA 04/2014 - 07/2010
4	bucillamine (SA 96)IBA 10/2013 - 01/2005
4	Allopurinol (Remid)FDA LinkGeneric 06/2011 - 06/2011
3	golimumab FDA Link 07/2015 - 06/2012
3	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 12/2014 - 09/2012
3	cyclic citrullinated peptideIBA 01/2014 - 05/2011
3	Sulfasalazine (Azulfidine)FDA LinkGeneric 10/2013 - 12/2002
3	Tacrolimus (Prograf)FDA LinkGeneric 07/2013 - 10/2010
3	Interleukin-17 (Interleukin 27)IBA 08/2012 - 10/2009
2	abatacept (BELATACEPT)FDA Link 04/2015 - 09/2014
2	Interleukin-8 (Interleukin 8)IBA 12/2014 - 01/2014
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2014 - 12/2011
2	HLA-B Antigens (HLA-B)IBA 10/2013 - 08/2013
2	Biological Markers (Surrogate Marker)IBA 09/2012 - 03/2009
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/2011 - 01/2011
2	ChemokinesIBA 01/2010 - 01/2010
2	Matrix MetalloproteinasesIBA 01/2010 - 01/2007
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2009 - 04/2002
2	C-Reactive ProteinIBA 11/2008 - 01/2007
2	leflunomide (Arava)FDA LinkGeneric 01/2005 - 06/2003
1	sildenafil (Viagra)FDA Link 12/2015
1	Cyclic GMPIBA 12/2015
1	acetyl 4-aminosalicylic acidIBA 05/2015
1	Methylprednisolone FDA LinkGeneric 01/2015
1	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2015
1	GlucocorticoidsIBA 05/2014
1	Interleukin-15 (Interleukin 15)IBA 04/2014
1	arginine deiminaseIBA 01/2014
1	OsteoprotegerinIBA 01/2014
1	AntigensIBA 01/2014
1	25-hydroxyvitamin DIBA 01/2014

Therapy/Procedure

4	Arthroplasty 10/2011 - 01/2007
2	Complementary Therapies (Alternative Medicine) 07/2013 - 01/2006
2	Biological Therapy 03/2013 - 03/2009
2	Injections 01/2009 - 01/2006