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Christian Wunder Selected Research

Rolipram

1/2015Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression.
6/2014Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis.
6/2012Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation.

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Christian Wunder Research Topics

Disease

11Inflammation
07/2015 - 09/2003
7Sepsis (Septicemia)
07/2015 - 10/2005
5Ischemia
10/2010 - 05/2002
3Peritonitis
01/2015 - 06/2014
2Shock
01/2015 - 01/2013
2Infection
12/2014 - 01/2004
2Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
06/2014 - 07/2004
2Critical Illness (Critically Ill)
04/2014 - 01/2013
2Brain Injuries (Brain Injury)
05/2013 - 05/2012
2Edema
05/2013 - 02/2011
2Wounds and Injuries (Trauma)
05/2012 - 06/2011
2Lung Injury
02/2011 - 01/2007
2Neoplasms (Cancer)
01/2009 - 01/2004
1Cholera
01/2015
1Heart Arrest (Cardiac Arrest)
01/2015
1Acute Kidney Injury (Acute Renal Failure)
12/2014
1Renal Insufficiency (Renal Failure)
01/2013
1Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
05/2012
1Hemorrhage
05/2012
1Acidosis
01/2012
1Hypoglycemia (Reactive Hypoglycemia)
01/2012
1Air Embolism (Gas Embolism)
06/2011
1Respiratory Acidosis
04/2010
1Respiratory Insufficiency (Respiratory Failure)
01/2007
1Liver Diseases (Liver Disease)
01/2007
1Adrenocortical Adenoma (Disease, Conn's)
12/2006
1Pheochromocytoma
12/2006
1Neoplasm Metastasis (Metastasis)
12/2006
1Endotoxemia
10/2005
1Rhabdomyolysis
03/2005
1Peptic Ulcer (Peptic Ulcers)
11/2003
1Stomach Neoplasms (Stomach Cancer)
11/2003

Drug/Important Bio-Agent (IBA)

4Carbon MonoxideIBA
12/2014 - 10/2005
3Type 4 Cyclic Nucleotide PhosphodiesterasesIBA
01/2015 - 06/2012
3RolipramIBA
01/2015 - 06/2012
3Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
07/2004 - 05/2002
2Colloids (Colloid)IBA
01/2013 - 03/2010
2Arachidonic Acid (Vitamin F)IBA
01/2009 - 11/2003
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2009 - 11/2003
2salicylhydroxamic acid (SHAM)IBA
10/2005 - 05/2002
1cadherin 5IBA
07/2015
1ClathrinIBA
01/2015
1HES 130-0.4IBA
01/2015
1Urea (Carbamide)FDA LinkGeneric
12/2014
1CreatinineIBA
12/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2014
1Phosphodiesterase 4 InhibitorsIBA
06/2014
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
05/2013
1occludinIBA
05/2013
1bortezomib (Velcade)FDA Link
05/2013
1Dexamethasone (Maxidex)FDA LinkGeneric
05/2013
1Hetastarch (Pentastarch)FDA Link
01/2013
1RoflumilastIBA
06/2012
1Heparin (Liquaemin)FDA LinkGeneric
05/2012
1Interleukin-6 (Interleukin 6)IBA
01/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2010
1p38 Mitogen-Activated Protein KinasesIBA
10/2010
1crystalloid solutionsIBA
03/2010
1GastrinsIBA
01/2009
1Indocyanine Green (Cardio-Green)FDA LinkGeneric
01/2007
1Biological Markers (Surrogate Marker)IBA
01/2007
1OxygenIBA
01/2007
1Hyaluronic Acid (Hyaluronan)IBA
01/2007
1Lipid AIBA
12/2006
1PhenoxybenzamineFDA Link
12/2006
1acetovanillone (apocynin)IBA
05/2006
1Oxidants (Oxidizing Agents)IBA
05/2006
1Allopurinol (Remid)FDA LinkGeneric
05/2006
1EnzymesIBA
05/2006
1Messenger RNA (mRNA)IBA
10/2005
1Endothelin Receptors (Endothelin Receptor)IBA
10/2005
1tezosentanIBA
10/2005
1Endothelin-1 (Endothelin 1)IBA
10/2005
1Methylene Chloride (Dichloromethane)IBA
10/2005
1Heme (Haem)IBA
03/2005
1cobaltiprotoporphyrinIBA
03/2005
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
07/2004
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2004
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2004
1mesoporphyrin IXIBA
05/2002

Therapy/Procedure

3Stents
01/2015 - 06/2014
3Resuscitation
01/2015 - 06/2012
3Positive-Pressure Respiration (PEEP)
06/2011 - 01/2007
2Ligation
01/2012 - 03/2010
1Cardiopulmonary Resuscitation (CPR)
01/2015
1Defibrillators (Defibrillator)
01/2015
1Intensive Care (Surgical Intensive Care)
12/2014
1Parenteral Nutrition
04/2014
1Subcutaneous Injections
05/2013
1Renal Replacement Therapy (Therapies, Renal Replacement)
01/2013
1Artificial Respiration (Mechanical Ventilation)
05/2012
1Extracorporeal Membrane Oxygenation (ECMO)
05/2012
1Fluid Therapy (Oral Rehydration Therapy)
02/2011
1Adrenalectomy
12/2006