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David C Whitcomb Selected Research

Hereditary pancreatitis

3/2014The histopathology of PRSS1 hereditary pancreatitis.
5/2012Whole exome sequencing identifies multiple, complex etiologies in an idiopathic hereditary pancreatitis kindred.
3/2010The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families.
8/2009Inflammation and pancreatic cancer: an evidence-based review.
11/2007Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis.
1/2006Keratin 8 mutations are not associated with familial, sporadic and alcoholic pancreatitis in a population from the United States.
8/2004Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer.
3/2004Clinical and genetic characteristics of hereditary pancreatitis in Europe.
6/2002Hereditary pancreatitis: a model for inflammatory diseases of the pancreas.

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David C Whitcomb Research Topics

Disease

42Pancreatitis
01/2016 - 01/2002
31Chronic Pancreatitis
01/2015 - 01/2002
12Pancreatic Neoplasms (Pancreatic Cancer)
03/2015 - 03/2004
8Inflammation
10/2015 - 06/2002
7Necrosis
01/2016 - 02/2006
7Fibrosis (Cirrhosis)
11/2013 - 01/2004
5Adenocarcinoma
10/2015 - 08/2004
4Pain (Aches)
07/2012 - 11/2007
4Neoplasms (Cancer)
02/2011 - 01/2003
4Cystic Fibrosis (Mucoviscidosis)
01/2011 - 01/2003
3Diabetes Mellitus
01/2014 - 01/2004
3Alcoholic Pancreatitis
09/2012 - 07/2002
2Pancreatic Cyst
05/2014 - 10/2005
2Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
03/2012 - 02/2010
2Exocrine Pancreatic Insufficiency
04/2011 - 10/2010
2Obesity
11/2009 - 08/2009
2Infection
01/2006 - 01/2002
2Genetic Predisposition to Disease (Genetic Predisposition)
08/2003 - 10/2002
1Pneumonia (Pneumonitis)
01/2016
1Fat Necrosis
01/2016
1Pancreatic Diseases (Pancreatic Disease)
11/2015
1Hypertriglyceridemia
07/2015
1Venous Thrombosis (Deep-Vein Thrombosis)
05/2014
1Edema
04/2014
1Atrophy
03/2014
1Endotoxemia
11/2013
1Disease Progression
09/2013
1Disease Susceptibility (Diathesis)
12/2012
1Multiple Organ Failure (MODS)
03/2012
1Liver Cirrhosis (Hepatic Cirrhosis)
11/2011
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2011
1Abdominal Pain (Pain, Abdominal)
10/2010
1Nutrition Disorders (Nutritional Disorders)
10/2010
1Flatulence
10/2010
1Malnutrition
10/2010
1Weight Loss (Weight Reduction)
10/2010

Drug/Important Bio-Agent (IBA)

10TrypsinogenIBA
12/2012 - 09/2002
9Hereditary pancreatitisIBA
03/2014 - 06/2002
9TrypsinIBA
09/2012 - 09/2002
8DNA (Deoxyribonucleic Acid)IBA
10/2015 - 03/2003
5CytokinesIBA
01/2016 - 01/2004
5Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
01/2010 - 09/2002
4Biological Markers (Surrogate Marker)IBA
12/2015 - 08/2008
4Urea (Carbamide)FDA LinkGeneric
12/2015 - 01/2009
4NitrogenIBA
12/2015 - 01/2009
4Serine Proteases (Serine Protease)IBA
02/2010 - 01/2003
3Caerulein (Ceruletide)IBA
01/2016 - 01/2005
3CreatinineIBA
12/2015 - 01/2009
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2012 - 03/2003
3Codon (Codons)IBA
01/2009 - 01/2004
2AmylasesFDA Link
08/2015 - 04/2014
2chymotrypsinogen CIBA
01/2015 - 01/2010
2Arginine (L-Arginine)FDA Link
04/2014 - 01/2004
2CollagenIBA
11/2013 - 01/2005
2Carbon MonoxideIBA
07/2013 - 07/2008
2Pancrelipase (Creon)FDA Link
04/2011 - 10/2010
2Calcium-Sensing ReceptorsIBA
01/2010 - 07/2008
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
02/2009 - 11/2004
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2006 - 05/2005
2Interferon-gamma (Interferon, gamma)IBA
01/2004 - 01/2004
2Interleukin-10 (Interleukin 10)IBA
01/2004 - 01/2004
1TrioleinIBA
01/2016
1orlistat (Xenical)FDA Link
01/2016
1Lipase (Acid Lipase)FDA Link
01/2016
1InterleukinsIBA
01/2016
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2016
1Triglycerides (Triacylglycerol)IBA
10/2015
1Cholecystokinin (Pancreozymin)IBA
03/2015
1Cholecystokinin B ReceptorIBA
03/2015
1GastrinsIBA
03/2015
1MicroRNAs (MicroRNA)IBA
10/2014
1AnticoagulantsIBA
05/2014
1Nucleosomes (Nucleosome)IBA
04/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2014
1HMGB1 Protein (HMG1)IBA
04/2014
1Acetylcysteine (Siran)FDA LinkGeneric
04/2014
1Histones (Histone)IBA
01/2014
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2014
1isothiocyanic acidIBA
01/2014
1phenethyl isothiocyanate (PEITC)IBA
01/2014
1Transforming Growth Factors (Transforming Growth Factor)IBA
11/2013
1ORALIT (ORS)IBA
07/2013
1Narcotics (Narcotic Analgesics)IBA
07/2012
1Blood Group Antigens (Blood Groups)IBA
11/2011
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
02/2011
1Proteins (Proteins, Gene)IBA
02/2011
1Platelet-Derived Growth FactorIBA
11/2010
1Angiopoietin-2IBA
10/2010
1Epidermal Growth Factor (EGF)IBA
09/2010
1Toll-Like Receptor 4IBA
08/2010

Therapy/Procedure

2Pancreatectomy
01/2014 - 07/2013
2Individualized Medicine
09/2013 - 07/2012
2Resuscitation
04/2011 - 01/2009
1Blood Component Removal (Apheresis)
07/2015
1Patient Discharge
11/2014
1Stents
05/2014
1Chemoprevention
01/2014
1Oral Administration
01/2014
1Heterologous Transplantation (Xenotransplantation)
01/2014
1Enzyme Replacement Therapy
10/2010