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Selwyn M Vickers Selected Research

triptolide

5/2015Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
8/2014Sorafenib and triptolide as combination therapy for hepatocellular carcinoma.
6/2014Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
6/2014Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
11/2013Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
4/2013Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity.
1/2013miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.
1/2013Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo.
10/2012A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer.
10/2010Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.
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Selwyn M Vickers Research Topics

Disease

43Neoplasms (Cancer)
10/2015 - 02/2002
33Pancreatic Neoplasms (Pancreatic Cancer)
05/2015 - 02/2002
14Adenocarcinoma
10/2015 - 07/2002
5Chronic Pancreatitis
07/2014 - 10/2006
5Cholangiocarcinoma
06/2011 - 06/2002
4Neoplasm Metastasis (Metastasis)
05/2015 - 09/2007
4Carcinoma (Carcinomatosis)
07/2007 - 05/2003
3Pain (Aches)
07/2014 - 04/2012
3Neuroblastoma
04/2013 - 08/2009
2Pancreatitis
07/2014 - 04/2014
2Body Weight (Weight, Body)
07/2014 - 04/2014
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013 - 04/2007
1Hepatocellular Carcinoma (Hepatoma)
08/2014
1Tics (Tic)
05/2014
1Fibrosis (Cirrhosis)
04/2014
1Hypersensitivity (Allergy)
10/2013
1Diarrhea
10/2013
1Anaphylaxis (Anaphylactic Shock)
10/2013
1Shock
04/2013
1Sphincter of Oddi Dysfunction
04/2012
1Stomach Neoplasms (Stomach Cancer)
01/2011
1Residual Neoplasm
09/2010
1Sarcoma (Soft Tissue Sarcoma)
07/2010

Drug/Important Bio-Agent (IBA)

16triptolideIBA
05/2015 - 10/2007
6Proteins (Proteins, Gene)IBA
05/2015 - 05/2005
6Small Interfering RNA (siRNA)IBA
01/2012 - 05/2005
5gemcitabineFDA Link
04/2008 - 05/2003
5Epidermal Growth Factor Receptor (EGF Receptor)IBA
11/2007 - 12/2004
4Messenger RNA (mRNA)IBA
04/2013 - 02/2002
4RNA (Ribonucleic Acid)IBA
01/2012 - 02/2006
4erlotinib (CP 358,774)FDA Link
11/2007 - 04/2007
3InterferonsIBA
05/2015 - 11/2012
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 02/2010
3Epidermal Growth Factor (EGF)IBA
08/2010 - 05/2003
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2008 - 10/2003
3TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
12/2007 - 11/2006
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2007 - 04/2007
2DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2015 - 09/2010
2Interferon-alpha (Interferon Alfa)FDA Link
05/2015 - 07/2012
2Caspase 3 (Caspase-3)IBA
05/2015 - 02/2010
2Insulin (Novolin)FDA Link
07/2014 - 04/2014
2Pain-FreeIBA
04/2014 - 04/2012
2Fluorouracil (Carac)FDA LinkGeneric
02/2014 - 04/2008
2AntigensIBA
10/2013 - 07/2013
2OvalbuminIBA
10/2013 - 07/2013
2megakaryocyte potentiating factorIBA
07/2013 - 10/2006
2HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
05/2009 - 10/2007
2LigandsIBA
05/2005 - 07/2002
2Transforming Growth Factor beta (TGF-beta)IBA
05/2005 - 04/2004
2Interferon-gamma (Interferon, gamma)IBA
04/2005 - 06/2002
2cetuximab (Erbitux)FDA Link
12/2004 - 05/2003
1PeptidesIBA
10/2015
1pHLIP proteinIBA
10/2015
1Transcription Factors (Transcription Factor)IBA
05/2015
1Annexin A5IBA
05/2015
1sorafenib (BAY 43-9006)FDA Link
08/2014
1Peptide Initiation Factors (Initiation Factor)IBA
06/2014
1Phosphotransferases (Kinase)IBA
06/2014
1Inositol (Myoinositol)IBA
06/2014
1TrypsinIBA
04/2014
1Serine Proteases (Serine Protease)IBA
04/2014
1Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
04/2014
1Cisplatin (Platino)FDA LinkGeneric
02/2014
1Sp1 Transcription FactorIBA
11/2013
1NF-kappa B (NF-kB)IBA
04/2013
1Apoptosis Regulatory ProteinsIBA
01/2013
1Narcotics (Narcotic Analgesics)IBA
04/2012
1Glycoproteins (Glycoprotein)IBA
01/2012
1Cathepsin BIBA
01/2012
1GO 201IBA
01/2012
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
02/2011
1Death Domain ReceptorsIBA
10/2010
1Interleukin-13 Receptors (Interleukin 13 Receptor)IBA
08/2010
1Interleukin-13IBA
08/2010
1Caspase 9IBA
02/2010
1Heat-Shock Proteins (Heat-Shock Protein)IBA
08/2009
1CalciumIBA
05/2009
1QuercetinIBA
05/2009
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
11/2007
1irinotecan (Camptosar)FDA LinkGeneric
09/2007
1Cyclin-Dependent Kinase Inhibitor p16IBA
09/2007
1DNA (Deoxyribonucleic Acid)IBA
04/2007
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
12/2006

Therapy/Procedure

13Heterologous Transplantation (Xenotransplantation)
01/2013 - 06/2002
4Pancreatectomy
07/2014 - 09/2011
4Drug Therapy (Chemotherapy)
08/2010 - 07/2002
3Injections
09/2010 - 09/2007
3Cholecystectomy
04/2009 - 11/2005
2Lymph Node Excision (Lymph Node Dissection)
01/2011 - 01/2010
2Pancreaticoduodenectomy
03/2010 - 04/2008
2Neoadjuvant Therapy
03/2010 - 08/2008
1Transplantation (Transplant Recipients)
04/2014
1Transplants (Transplant)
04/2014
1Immunotherapy
10/2013
1Gastrectomy
01/2011
1Hepatectomy
11/2010
1Radiotherapy
07/2010
1Adjuvant Chemotherapy
04/2008
1Aftercare (After-Treatment)
09/2007
1Lasers (Laser)
04/2007