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A S Verkman Selected Research

Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)

10/2015Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.
10/2015Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.
12/2014ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
7/2014Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.
12/2013Chloride channel-targeted therapy for secretory diarrheas.
2/2013Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs.
9/2012CFTR inhibitors for treating diarrheal disease.
2/2012Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein.
8/2011Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.
5/2010Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.
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A S Verkman Research Topics

Disease

33Neuromyelitis Optica (Devic's Disease)
11/2014 - 01/2009
29Cystic Fibrosis (Mucoviscidosis)
10/2015 - 06/2001
16Demyelinating Diseases (Demyelinating Disease)
11/2014 - 01/2009
14Diarrhea
02/2014 - 12/2003
13Neoplasms (Cancer)
03/2014 - 01/2003
11Inflammation
09/2014 - 12/2002
9Brain Edema (Cerebral Edema)
03/2014 - 09/2001
8Nephrogenic Diabetes Insipidus
01/2012 - 04/2000
7Cholera
09/2012 - 12/2003
6Edema
01/2015 - 12/2000
5Polycystic Kidney Diseases (Polycystic Kidney Disease)
10/2015 - 05/2008
5Lung Diseases (Lung Disease)
06/2009 - 03/2006
5Seizures (Seizure)
01/2008 - 01/2004
4Autoimmune Diseases (Autoimmune Disease)
05/2014 - 01/2009
4Glaucoma
01/2008 - 01/2005
3Infection
07/2014 - 01/2008
3Multiple Sclerosis
03/2012 - 08/2005
3Cataract (Cataracts)
01/2012 - 09/2006
3Fibrosis (Cirrhosis)
10/2011 - 09/2004
3Hydrocephalus (Hydrocephaly)
01/2011 - 12/2006
3Wounds and Injuries (Trauma)
08/2009 - 10/2006
3Water Intoxication
08/2008 - 09/2004
3Epilepsy (Aura)
01/2008 - 01/2005
3Obesity
01/2008 - 01/2005
3Ischemia
03/2006 - 12/2004
2Neoplasm Metastasis (Metastasis)
03/2014 - 01/2008
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
05/2011 - 01/2009
2Pain (Aches)
01/2011 - 03/2006
2Cysts
10/2009 - 07/2008
2Polyuria
08/2006 - 10/2005
2Shock
02/2004 - 02/2000
2Lung Injury
12/2002 - 06/2000
2Pleural Effusion (Pleural Effusions)
12/2000 - 06/2000
1Psoriasis (Pustulosis Palmaris et Plantaris)
01/2015
1Hyponatremia
09/2014
1Brain Ischemia (Cerebral Ischemia)
06/2014
1Heart Arrest (Cardiac Arrest)
06/2014
1Adenoma (Adenomas)
03/2014
1Optic Neuritis (Retrobulbar Neuritis)
09/2013
1Nasal Polyps (Nasal Polyp)
09/2013
1Hypertension (High Blood Pressure)
01/2011
1Encephalitis (Encephalitis, Rasmussen)
02/2010

Drug/Important Bio-Agent (IBA)

30Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10/2015 - 06/2001
25AutoantibodiesIBA
11/2014 - 01/2009
25Immunoglobulin G (IgG)IBA
09/2014 - 08/2005
23Chloride Channels (Chloride Channel)IBA
10/2015 - 01/2003
20Aquaporins (Water Channels)IBA
01/2012 - 04/2000
15Complement System Proteins (Complement)IBA
11/2014 - 02/2010
7EnterotoxinsIBA
02/2014 - 12/2003
6Glycerol (Glycerine)FDA LinkGeneric
09/2008 - 04/2005
5Cholera ToxinIBA
07/2014 - 08/2004
5cystic fibrosis transmembrane conductance regulator delta F508IBA
01/2010 - 09/2004
4DiureticsIBA
09/2014 - 01/2005
4Aquaporin 2IBA
02/2009 - 01/2001
3Phenylalanine (L-Phenylalanine)FDA Link
12/2014 - 09/2005
3Immunoglobulins (Immunoglobulin)IBA
09/2013 - 02/2010
3Aquaporin 4IBA
06/2012 - 04/2005
3fluorexon (calcein)IBA
08/2009 - 02/2004
3Adenosine Triphosphate (ATP)IBA
09/2008 - 03/2008
2Phenobarbital (Luminal)FDA Link
03/2014 - 12/2013
2Acetaminophen (Paracetamol)FDA LinkGeneric
03/2014 - 09/2006
2Aquaporin 1IBA
03/2014 - 01/2011
2AntibodiesIBA
12/2012 - 06/2012
2Protein Isoforms (Isoforms)IBA
05/2011 - 12/2009
2oligodendrocyte-myelin glycoproteinIBA
05/2011 - 01/2009
2KaolinIBA
01/2011 - 12/2006
2Carbon MonoxideIBA
02/2010 - 12/2002
2STF 62247IBA
08/2008 - 01/2006
2glycine hydrazideIBA
07/2008 - 01/2006
2Dextrans (Dextran)FDA Link
01/2008 - 11/2007
2fluorescein isothiocyanate dextranIBA
01/2008 - 03/2005
2Retinaldehyde (Retinal)IBA
03/2006 - 12/2004
2Pentylenetetrazole (Metrazol)IBA
01/2006 - 02/2004
2AntidiarrhealsIBA
01/2006 - 08/2004
2ConvulsantsIBA
09/2004 - 01/2004
2ThioureaIBA
12/2000 - 06/2000
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2015
1Evans Blue (Blue, Evans)FDA Link
01/2015
1Vasopressins (Vasopressin)IBA
09/2014
1Complement Membrane Attack Complex (Membrane Attack Complex)IBA
09/2014
1hippuryl-glycyl-glycine (HIGG)IBA
05/2014
1Thioacetamide (Thioacetamid)IBA
03/2014
1AmmoniaIBA
03/2014
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
03/2014
1Glial Fibrillary Acidic ProteinIBA
01/2014
1ForskolinIBA
09/2013
1Granzymes (Granzyme)IBA
12/2012
1PerforinIBA
12/2012
1Adenosine Monophosphate (AMP)IBA
09/2012
1Leukocyte Elastase (Neutrophil Elastase)IBA
03/2012
1Cyclic AMP (AMP, Cyclic)IBA
02/2012
1Excitatory Amino Acid Transporter 2IBA
12/2011
1Luxol Fast Blue MBS (Luxol fast blue)IBA
06/2011

Therapy/Procedure

3Therapeutics
04/2014 - 05/2013
3Drug Therapy (Chemotherapy)
11/2011 - 05/2008
1Combination Drug Therapy (Combination Chemotherapy)
10/2015
1Oral Administration
07/2014
1Resuscitation
06/2014
1Intraperitoneal Injections
01/2014
1Plasma Exchange
09/2013