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Yoshihiro Uto Selected Research

2-nitroimidazole acetamide

10/2009Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
12/2008The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.
12/2006Design of hypoxia-targeting drugs as new cancer chemotherapeutics.
9/2005TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.
5/2002Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma.

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Yoshihiro Uto Research Topics

Disease

31Neoplasms (Cancer)
08/2015 - 05/2002
9Anoxia (Hypoxia)
08/2012 - 05/2002
5Fever (Fevers)
03/2014 - 01/2003
4Inflammation
06/2008 - 11/2002
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2006 - 01/2003
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2012 - 03/2004
3Neoplasm Metastasis (Metastasis)
10/2009 - 09/2005
2Breast Neoplasms (Breast Cancer)
08/2014 - 07/2013
2Cardiovascular Diseases (Cardiovascular Disease)
05/2014 - 01/2013
2Ascites
07/2013 - 05/2002
2Prostatic Neoplasms (Prostate Cancer)
07/2013 - 03/2009
1Prion Diseases (Transmissible Spongiform Encephalopathies)
08/2014
1Heart Diseases (Heart Disease)
08/2014
1Lewis Lung Carcinoma
07/2013
1Lung Neoplasms (Lung Cancer)
07/2013
1Colorectal Neoplasms (Colorectal Cancer)
07/2013
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Rectal Neoplasms (Rectal Cancer)
10/2009
1Colonic Neoplasms (Colon Cancer)
10/2009
1Neurofibromatoses (Neurofibromatosis)
03/2009
1AIDS-Related Complex (ARC)
03/2009
1Peritonitis
06/2008
1Chronic Obstructive Pulmonary Disease (COPD)
11/2006
1Brain Neoplasms (Brain Tumor)
02/2006
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2003

Drug/Important Bio-Agent (IBA)

10vitamin D-binding protein-macrophage activating factorIBA
08/2014 - 05/2002
7Bromodeoxyuridine (BrdU)IBA
01/2007 - 01/2003
6tirapazamine (SR 4233)IBA
09/2010 - 01/2003
6Cytochalasin BIBA
03/2006 - 01/2003
52-nitroimidazole acetamideIBA
10/2009 - 05/2002
5SuspensionsIBA
03/2006 - 01/2003
4BoronIBA
08/2014 - 12/2006
43-amino-2-quinoxalinecarbonitrileIBA
12/2006 - 11/2003
4CytotoxinsIBA
12/2006 - 05/2002
4SASIBA
03/2006 - 01/2003
3Proteins (Proteins, Gene)IBA
08/2014 - 11/2006
3Vitamin D-Binding ProteinIBA
07/2013 - 09/2004
3TX 2100IBA
09/2010 - 02/2006
3Propolis (Bee Bread)IBA
05/2009 - 07/2007
3artepillin CIBA
03/2009 - 07/2007
2EtanidazoleIBA
08/2014 - 01/2011
2AntioxidantsIBA
05/2014 - 05/2002
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2012 - 11/2003
2Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
09/2010 - 09/2008
2N-acetylcochinol-O-phosphateIBA
01/2007 - 08/2005
2DNA (Deoxyribonucleic Acid)IBA
12/2006 - 06/2005
2Cisplatin (Platino)FDA LinkGeneric
06/2005 - 01/2003
1Advanced Glycosylation End ProductsIBA
08/2014
1tin(IV) chlorin e6IBA
08/2014
1chlorin e6IBA
08/2014
1HormonesIBA
08/2014
1protoporphyrin IXIBA
08/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
03/2014
1Cholecalciferol (Vitamin D3)FDA Link
07/2013
1Sepharose (Agarose)IBA
07/2013
1VitaminsIBA
07/2013
1MannosidasesIBA
07/2013
1Thioctic Acid (Lipoic Acid)IBA
07/2013
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
07/2013
1Bovine Serum AlbuminIBA
01/2013
1LipidsIBA
01/2013
1Lipoproteins (Lipoprotein)IBA
01/2013
12- (2- methoxy- 4- nitrophenyl)- 3- (4- nitrophenyl)- 5- (2,4- disulfophenyl)- 2H tetrazolium monosodium saltIBA
08/2012
1Antineoplastic Agents (Antineoplastics)IBA
09/2010
1mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA
03/2010
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
10/2009
1Plasminogen Activators (Plasminogen Activator)IBA
10/2009
1caffeic acid phenethyl esterIBA
03/2009
1Phosphotransferases (Kinase)IBA
03/2009
1CarrageenanIBA
06/2008
1NF-kappa B (NF-kB)IBA
06/2008
1TX-1898IBA
12/2006
1MisonidazoleIBA
03/2006
1NimorazoleIBA
03/2006
1mercaptoundecahydrododecaborate (borocaptate sodium)IBA
02/2006
1Actins (F Actin)IBA
11/2005
1Vitamin DFDA LinkGeneric
11/2005
1ChemokinesIBA
09/2005
1Carbon MonoxideIBA
08/2005
1Vincristine (Oncovin)FDA LinkGeneric
06/2005
1Etoposide (VP 16)FDA LinkGeneric
06/2005
1Doxorubicin (Adriamycin)FDA LinkGeneric
06/2005
1Dactinomycin (Ac-De)FDA LinkGeneric
06/2005
1Messenger RNA (mRNA)IBA
06/2005
1TX-2060IBA
09/2004
14-cyclopentene-1,3-dioneIBA
03/2004
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2004
12- hydroxyarylidene- 4- cyclopentene- 1,3- dioneIBA
03/2004
1squamous cell of head and neck CarcinomaIBA
11/2003
1Paclitaxel (Taxol)FDA LinkGeneric
01/2003
12- nitroimidazole- 1- methylacetohydroxamateIBA
05/2002

Therapy/Procedure

5Immunotherapy
08/2015 - 07/2013
4Heterologous Transplantation (Xenotransplantation)
10/2009 - 06/2005
4Boron Neutron Capture Therapy
12/2006 - 09/2004
2Drug Therapy (Chemotherapy)
05/2014 - 03/2010
2Therapeutics
03/2009 - 12/2006
1Aftercare (After-Treatment)
01/2012
1Radiotherapy
03/2006
1Oral Administration
01/2003
1Intraperitoneal Injections
01/2003