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Karel Ulbrich Selected Research

hydroxypropyl methacrylate

2/2015Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice.
12/2013Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution.
12/2013HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy.
3/2013Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.
2/2013Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo.
1/2013Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.
1/2013Noninvasive optical imaging of nanomedicine biodistribution.
12/2012HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity.
8/2012Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system.
3/2012Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging.
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Karel Ulbrich Research Topics

Disease

50Neoplasms (Cancer)
02/2015 - 01/2003
8Infection
11/2013 - 02/2008
7T-Cell Lymphoma (Lymphoma, T Cell)
12/2012 - 10/2003
5Carcinoma (Carcinomatosis)
12/2013 - 08/2002
3Leukemia
03/2013 - 05/2002
2Melanoma (Melanoma, Malignant)
10/2011 - 10/2010
2Ovarian Neoplasms (Ovarian Cancer)
03/2008 - 02/2008
1Arthritis (Polyarthritis)
01/2014
1Sarcoma (Soft Tissue Sarcoma)
02/2013
1Kidney Neoplasms (Kidney Cancer)
10/2011
1Necrosis
03/2011
1Prostatic Neoplasms (Prostate Cancer)
11/2010
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
02/2009
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2008
1Fever (Fevers)
02/2007
1Breast Neoplasms (Breast Cancer)
08/2003

Drug/Important Bio-Agent (IBA)

29hydroxypropyl methacrylateIBA
02/2015 - 05/2002
28PolymersIBA
02/2015 - 09/2007
23Doxorubicin (Adriamycin)FDA LinkGeneric
01/2014 - 08/2003
13N-(2-hydroxypropyl)methacrylamideIBA
01/2014 - 08/2003
8MicellesIBA
02/2015 - 10/2009
6Drug CarriersIBA
02/2015 - 07/2009
3DuxonIBA
02/2015 - 02/2013
3methacrylamideIBA
03/2011 - 10/2009
2pirarubicinIBA
02/2015 - 01/2014
2Liposomes (Liposome)IBA
01/2014 - 07/2009
2CholesterolIBA
01/2013 - 08/2012
2Carbon MonoxideIBA
01/2013 - 12/2012
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
12/2012 - 02/2008
2Immunoglobulins (Immunoglobulin)IBA
09/2007 - 08/2003
1ellipticineIBA
02/2015
1NGR peptideIBA
02/2014
1arginyl-glycyl-aspartic acidIBA
02/2014
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2014
1ProdrugsIBA
01/2014
1Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2013
1Cytostatic AgentsIBA
03/2013
1zinc protoporphyrinIBA
02/2013
1Singlet OxygenIBA
02/2013
1bionoleIBA
01/2013
1Interleukin-12 (IL 12)IBA
10/2011
1InterleukinsIBA
10/2011
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
10/2011
1SuspensionsIBA
09/2011
1Cytochrome P-450 CYP2D6 (CYP2D6)IBA
09/2011
1S-mephenytoin N-demethylase (CYP2B6)IBA
09/2011
1CytochromesIBA
09/2011
1Cytochrome P-450 CYP1A2 (CYP1A2)IBA
09/2011
1Cytochrome P-450 CYP2E1 (CYP2E1)IBA
09/2011
1AN 204 (AN 201)IBA
08/2011
1DNA (Deoxyribonucleic Acid)IBA
06/2011
1Cathepsin BIBA
04/2011
1LuciferasesIBA
03/2011
1E-SelectinIBA
03/2011
1human glutamate carboxypeptidase IIIBA
11/2010
1Single-Chain AntibodiesIBA
11/2010
1Lactic AcidFDA LinkGeneric
10/2010
1monomethoxypolyethylene glycol (MPEG)IBA
10/2010
1Ethylene Glycol (Monoethylene Glycol)IBA
10/2010
1OligopeptidesIBA
12/2009
1AntigensIBA
11/2009
1poly-N-isopropylacrylamideIBA
10/2009
1Radioisotopes (Radionuclides)IBA
10/2009
1gemcitabineFDA Link
07/2009
1tyrosinamideIBA
07/2009
1Factor X (Stuart Factor)IBA
04/2009
1adenovirus receptorIBA
02/2009
1LigandsIBA
04/2008
1N-Acetylneuraminic Acid (Sialic Acid)IBA
04/2008
1Immune Sera (Antisera)IBA
04/2008
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
04/2008
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
03/2008
1Epidermal Growth Factor (EGF)IBA
02/2008
1Gadolinium DTPA (Magnevist)FDA Link
01/2006
1Biotin (Vitamin H)FDA Link
08/2002
1HydrogelIBA
05/2002
1HydrogelsIBA
05/2002

Therapy/Procedure

7Therapeutics
11/2013 - 12/2005
6Drug Therapy (Chemotherapy)
12/2011 - 08/2003
5Heterologous Transplantation (Xenotransplantation)
12/2013 - 02/2008
2Radiotherapy
12/2010 - 02/2007
2Transplants (Transplant)
10/2009 - 12/2008
1Microbubbles
11/2013
1Aftercare (After-Treatment)
08/2013
1Transplantation (Transplant Recipients)
02/2009
1Intravenous Injections
10/2006