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Kazuhiro Takuma Selected Research

spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- one

2/2007A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.

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Kazuhiro Takuma Research Topics

Disease

11Alzheimer Disease (Alzheimer's Disease)
02/2013 - 04/2004
10Schizophrenia (Dementia Praecox)
02/2013 - 02/2007
4Parkinson Disease (Parkinson's Disease)
05/2012 - 03/2007
3Autistic Disorder (Autism)
08/2015 - 02/2013
3Pain (Aches)
01/2014 - 05/2013
3Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
08/2013 - 07/2010
3Memory Disorders (Memory Loss)
02/2013 - 06/2008
3Neurodegenerative Diseases (Neurodegenerative Disease)
08/2011 - 10/2008
2Seizures (Seizure)
09/2015 - 09/2011
2Pervasive Child Development Disorders
02/2013 - 01/2012
2Alcoholism (Alcohol Abuse)
02/2012 - 01/2011
2Bipolar Disorder (Mania)
02/2012 - 01/2011
1Epilepsy (Aura)
09/2015
1Learning Disorders (Learning Disability)
11/2014
1Hyperalgesia
11/2013
1Dyskinesias (Dyskinesia)
05/2012
1Neuroblastoma
08/2011
1Amyloid Plaque
03/2005
1Shock
08/2002

Drug/Important Bio-Agent (IBA)

4Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
08/2015 - 01/2012
35-HT1A Serotonin ReceptorIBA
01/2014 - 05/2013
3Galantamine (Galanthamine)FDA LinkGeneric
02/2013 - 01/2011
3Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2011 - 10/2008
3Methamphetamine (Desoxyn)FDA LinkGeneric
01/2009 - 03/2007
2Sodium-Calcium ExchangerIBA
09/2015 - 08/2011
2Messenger RNA (mRNA)IBA
09/2015 - 07/2009
2Serotonin (5 Hydroxytryptamine)IBA
11/2013 - 08/2013
2Methylphenidate (Ritalin)FDA LinkGeneric
08/2013 - 07/2010
2Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
02/2013 - 06/2010
2Levodopa (L Dopa)FDA LinkGeneric
05/2012 - 03/2007
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
12/2011 - 10/2008
2Amyloid beta-PeptidesIBA
11/2009 - 03/2005
2GABA-B Receptors (Receptor, GABA-B)IBA
01/2009 - 12/2008
2HormonesIBA
06/2008 - 03/2008
1Neurotransmitter Agents (Neurotransmitter)IBA
08/2015
1SodiumIBA
11/2014
1Butyrates (Butyrate)IBA
11/2014
1LigandsIBA
01/2014
1MKC 242IBA
11/2013
1venlafaxine (Effexor)FDA LinkGeneric
08/2013
1duloxetine (Cymbalta)FDA Link
08/2013
1Norepinephrine (Noradrenaline)FDA LinkGeneric
08/2013
1Acetic Acid (Vinegar)FDA LinkGeneric
05/2013
1Glutamic Acid (Glutamate)FDA Link
02/2013
1Histones (Histone)IBA
02/2013
1MGS 0028IBA
02/2013
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
05/2012
1pimagedine (aminoguanidine)IBA
05/2012
1NG-Nitroarginine Methyl Ester (L-NAME)IBA
05/2012
1Oxidopamine (6 Hydroxydopamine)IBA
05/2012
17-nitroindazoleIBA
05/2012
1Dopamine (Intropin)FDA LinkGeneric
05/2012
1SEA 0400IBA
12/2011
1Brain-Derived Neurotrophic Factor (BDNF)IBA
09/2011
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
09/2011
1brain-derived neurotrophic factor precursorIBA
09/2011
1Pentylenetetrazole (Metrazol)IBA
09/2011
1SB 203580IBA
08/2011
1Phosphotransferases (Kinase)IBA
08/2011
1JNK Mitogen-Activated Protein KinasesIBA
08/2011
1U 0126 (UO 126)IBA
08/2011
1p38 Mitogen-Activated Protein KinasesIBA
08/2011
1atomoxetine (Strattera)FDA LinkGeneric
07/2010
1NeuropeptidesIBA
06/2010
1Metalloproteases (Metalloproteinases)IBA
10/2009
1Extracellular Matrix ProteinsIBA
10/2009
1Matrix MetalloproteinasesIBA
10/2009
1maleic acid (maleate)IBA
10/2008
11-(3-(2-(1-benzothiophen-5-yl) ethoxy) propyl)-3-azetidinol maleateIBA
10/2008
1Estrogens (Estrogen)FDA Link
06/2008
1Minocycline (Cyclops)FDA LinkGeneric
02/2008
1Phencyclidine (Angel Dust)IBA
03/2007
1Dizocilpine Maleate (Dizocilpine)IBA
03/2007
1AdenosineFDA LinkGeneric
03/2007
1spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- oneIBA
02/2007
1donepezil (Aricept)FDA LinkGeneric
07/2005
1Memantine (Namenda)FDA Link
07/2005
1Amyloid (Amyloid Fibrils)IBA
04/2004
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
08/2002

Therapy/Procedure

1Ligation
11/2013
1Spinal Injections
11/2013
1Drug Therapy (Chemotherapy)
03/2007