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Tsutomu Takeuchi Selected Research

Rheumatoid Arthritis

2/2016Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
1/2016The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression.
1/2016Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial.
11/2015Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis.
10/2015The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, dose-ranging study.
10/2015Infliximab and etanercept have distinct actions but similar effects on cytokine profiles in rheumatoid arthritis.
10/2015Sustainable Efficacy of Switching From Intravenous to Subcutaneous Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis.
9/2015Long-term safety and efficacy of treatment with subcutaneous abatacept in Japanese patients with rheumatoid arthritis who are methotrexate inadequate responders.
7/2015Trend of patient characteristics and its impact on the response to adalimumab in patients with rheumatoid arthritis: post hoc time-course analysis of an all-case PMS in Japan.
7/2015Efficacy and safety of tofacitinib as monotherapy in Japanese patients with active rheumatoid arthritis: a 12-week, randomized, phase 2 study.
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Tsutomu Takeuchi Research Topics

Disease

107Rheumatoid Arthritis
02/2016 - 06/2004
24Infection
07/2015 - 12/2002
11Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2016 - 09/2003
9Cysts
06/2012 - 09/2002
7Inflammation
05/2015 - 06/2004
7Interstitial Lung Diseases (Interstitial Lung Disease)
01/2014 - 09/2005
6Pneumonia (Pneumonitis)
11/2012 - 01/2007
5Drug Toxicity (Drug Safety)
01/2016 - 11/2010
5Rheumatic Diseases (Rheumatism)
10/2011 - 01/2007
4Pain (Aches)
01/2015 - 05/2012
4Fever (Fevers)
01/2015 - 09/2005
4Autoimmune Diseases (Autoimmune Disease)
01/2013 - 08/2005
3Lupus Nephritis
01/2016 - 01/2007
3Ulcer
02/2015 - 05/2012
3Lung Diseases (Lung Disease)
01/2015 - 11/2012
3Connective Tissue Diseases (Connective Tissue Disease)
11/2013 - 10/2012
3Amebiasis (Amoebiasis)
03/2004 - 08/2003
2Sjogren's Syndrome (Sjogren Syndrome)
02/2016 - 08/2008
2Arthritis (Polyarthritis)
05/2015 - 01/2006
2Adult-Onset Still's Disease
05/2015 - 03/2012
2Mixed Connective Tissue Disease (MCTD)
02/2015 - 10/2012
2Systemic Scleroderma (Systemic Sclerosis)
02/2015 - 01/2007
2Acute Kidney Injury (Acute Renal Failure)
01/2015 - 01/2011
2Myositis (Idiopathic Inflammatory Myopathies)
01/2014 - 09/2005
2Acute Disease
01/2014 - 06/2005
2Body Weight (Weight, Body)
01/2014 - 01/2008
2Osteoarthritis
01/2013 - 05/2012
2Opportunistic Infections (Opportunistic Infection)
11/2012 - 01/2005
2Arthralgia (Joint Pain)
03/2012 - 07/2011
2Acquired Immunodeficiency Syndrome (AIDS)
07/2010 - 01/2008
2Amebic Dysentery (Amoebic Dysentery)
01/2010 - 05/2008
2Amebic Liver Abscess
01/2010 - 05/2008
2Lung Injury
10/2009 - 01/2008
2Communicable Diseases (Infectious Diseases)
03/2009 - 10/2003
2Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia)
01/2008 - 01/2007
2Tuberculosis (Tuberculoses)
01/2007 - 01/2005
2Colitis
04/2005 - 08/2003
2Chagas Disease (American Trypanosomiasis)
06/2003 - 03/2003
1Synovitis
02/2016
1Experimental Arthritis
05/2015
1Abdominal Pain (Pain, Abdominal)
01/2015

Drug/Important Bio-Agent (IBA)

30Methotrexate (Mexate)FDA LinkGeneric
01/2016 - 12/2004
24infliximab (Remicade)FDA Link
11/2015 - 01/2005
19tocilizumabFDA Link
10/2015 - 09/2007
15TNFR-Fc fusion protein (etanercept)FDA Link
10/2015 - 12/2002
14Interleukin-6 (Interleukin 6)IBA
01/2016 - 06/2004
12Antirheumatic Agents (DMARD)IBA
07/2015 - 01/2006
12Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2015 - 01/2005
8adalimumab (Humira)FDA Link
07/2015 - 06/2012
7Biological Markers (Surrogate Marker)IBA
02/2016 - 01/2009
7abatacept (BELATACEPT)FDA Link
09/2015 - 03/2013
7GlucocorticoidsIBA
01/2015 - 02/2003
7Prednisolone (Predate)FDA LinkGeneric
01/2015 - 09/2005
6CDP870FDA Link
01/2016 - 07/2014
6CytokinesIBA
10/2015 - 09/2005
6Messenger RNA (mRNA)IBA
06/2012 - 09/2003
5AntibodiesIBA
01/2015 - 02/2003
5Adrenal Cortex Hormones (Corticosteroids)IBA
01/2014 - 09/2005
5Tacrolimus (Prograf)FDA LinkGeneric
01/2014 - 02/2009
4C-Reactive ProteinIBA
05/2015 - 01/2008
4Idiopathic pulmonary hypertensionIBA
02/2015 - 01/2007
4Carbon MonoxideIBA
07/2014 - 12/2010
4AntigensIBA
04/2012 - 03/2004
4Immunosuppressive Agents (Immunosuppressants)IBA
01/2007 - 06/2005
4zeta chain antigen T cell receptor (TCR zeta chain)IBA
08/2005 - 09/2003
3beta-cyclodextrin tetradecasulfate (CTDS)IBA
02/2015 - 10/2012
3AutoantibodiesIBA
01/2014 - 01/2011
3leflunomide (Arava)FDA LinkGeneric
10/2009 - 01/2008
3DNA (Deoxyribonucleic Acid)IBA
09/2007 - 06/2003
2rituximab (Mabthera)FDA Link
01/2016 - 01/2007
2bucillamine (SA 96)IBA
10/2013 - 01/2006
2golimumabFDA Link
09/2013 - 06/2012
2EnzymesIBA
01/2013 - 10/2009
2Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2013 - 07/2011
2Immunoglobulin G (IgG)IBA
04/2012 - 01/2005
2Ferritins (Ferritin)IBA
03/2012 - 01/2002
2Interleukin-2 (IL2)IBA
01/2011 - 03/2005
2ametantrone (HAQ)IBA
08/2010 - 01/2009
2GelatinIBA
10/2009 - 01/2005
2T-Cell Antigen Receptors (T-Cell Receptor)IBA
03/2008 - 04/2005
23' Untranslated Regions (3' UTR)IBA
03/2008 - 01/2006
2polyglucosanIBA
01/2008 - 04/2007
2Cyclosporine (Ciclosporin)FDA LinkGeneric
01/2007 - 09/2005
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2007 - 09/2005
2Interleukin-7 Receptors (Interleukin 7 Receptor)IBA
04/2005 - 08/2003
2Recombinases (Recombinase)IBA
04/2005 - 08/2003
2T-Cell Antigen Receptor-CD3 ComplexIBA
03/2005 - 09/2003
1Interleukin-16 (Interleukin 16)IBA
02/2016
1N 30IBA
02/2016
1ChemokinesIBA
11/2015
1Leucine (L-Leucine)FDA Link
05/2015
1Glycoproteins (Glycoprotein)IBA
05/2015
1PTX3 proteinIBA
02/2015
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
02/2015
1erucylphosphocholineIBA
02/2015
1OsteopontinIBA
01/2015

Therapy/Procedure

4Biological Therapy
05/2015 - 11/2010
2Aftercare (After-Treatment)
05/2015 - 01/2011
2Artificial Respiration (Mechanical Ventilation)
10/2009 - 01/2008
2Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
02/2007 - 10/2002