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Hiroshi Takeshima Selected Research

nociceptin receptor

1/2008Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
2/2006The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.
7/2004Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.
6/2003Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.

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Hiroshi Takeshima Research Topics

Disease

6Pain (Aches)
01/2008 - 05/2003
5Heart Failure
01/2012 - 02/2009
4Inflammation
01/2012 - 07/2004
4Hyperalgesia
01/2008 - 05/2003
3Hypertension (High Blood Pressure)
04/2013 - 08/2011
3Fibrosis (Cirrhosis)
01/2012 - 02/2009
3Fatigue
09/2005 - 05/2002
2Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
10/2015 - 01/2007
2Reperfusion Injury
07/2010 - 06/2010
2Neoplasms (Cancer)
02/2010 - 11/2007
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2015
1Obesity
04/2012
1Huntington Disease (Huntington's Disease)
02/2012
1Hypertrophy
01/2012
1Cardiomegaly (Heart Hypertrophy)
12/2011
1Cardiovascular Diseases (Cardiovascular Disease)
09/2010
1Ischemia
09/2010
1Atherosclerosis
01/2010
1Muscular Dystrophies (Muscular Dystrophy)
06/2009
1Anoxia (Hypoxia)
02/2009
1Infection
07/2008
1Colitis
07/2008
1Heart Arrest (Cardiac Arrest)
01/2007
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2004
1Contracture
10/2003
1Tetanus
10/2003

Drug/Important Bio-Agent (IBA)

5nociceptinIBA
01/2008 - 05/2003
4junctophilinIBA
10/2015 - 12/2004
4Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
12/2011 - 05/2002
4nociceptin receptorIBA
01/2008 - 06/2003
3Biological Markers (Surrogate Marker)IBA
04/2013 - 08/2011
3Caveolin 3IBA
06/2010 - 12/2004
2Antihypertensive Agents (Antihypertensives)IBA
04/2013 - 08/2011
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2012 - 01/2012
2rho-Associated KinasesIBA
01/2012 - 02/2009
2Etoposide (VP 16)FDA LinkGeneric
02/2010 - 11/2007
2CalciumIBA
09/2005 - 05/2002
2Opioid Receptors (Opioid Receptor)IBA
07/2004 - 11/2003
1Neuropeptide YIBA
04/2012
1FR 167653IBA
01/2012
1Myosin-Light-Chain PhosphataseIBA
01/2012
1fasudil (AT 877)IBA
01/2012
1p38 Mitogen-Activated Protein KinasesIBA
01/2012
1apelin-13 peptideIBA
01/2012
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
01/2012
1NADPH Oxidase (NAD(P)H oxidase)IBA
01/2012
1CalcineurinIBA
12/2011
1Protein Kinases (Protein Kinase)IBA
12/2011
1valsartan (Vals)FDA Link
09/2010
1Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
09/2010
1eplerenone (Inspra)FDA LinkGeneric
09/2010
1CholesterolIBA
07/2010
1Phosphotransferases (Kinase)IBA
06/2010
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
06/2010
1Glycogen Synthase KinasesIBA
06/2010
1glycogen synthase kinase 3 betaIBA
06/2010
1A-Form DNA (A-DNA)IBA
02/2010
1Angiotensin Receptors (Angiotensin II Receptor)IBA
01/2010
1Fibronectins (Fibronectin)IBA
01/2010
1olmesartanIBA
01/2010
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
01/2010
1Collagen Type I (Type I Collagen)IBA
01/2010
1NG-Nitroarginine Methyl Ester (L-NAME)IBA
01/2010
1salicylhydroxamic acid (SHAM)IBA
08/2009
1Neurotransmitter Agents (Neurotransmitter)IBA
02/2009
1pitavastatin (itavastatin)FDA Link
02/2009
1wortmanninIBA
02/2009
1ChemokinesIBA
07/2008
1Reactive Oxygen Species (Oxygen Radicals)IBA
07/2008
1Dextran SulfateIBA
07/2008
1Messenger RNA (mRNA)IBA
01/2008
1gabapentin (Neurontin)FDA LinkGeneric
01/2008
1pronociceptinIBA
01/2008
11,4-dihydropyridine (dihydropyridine)IBA
01/2007
1NeuropeptidesIBA
02/2006
1Prostaglandin E Receptors (Prostaglandin E Receptor)IBA
02/2006
1Prostaglandins E (PGE)IBA
02/2006
1Prostaglandins F (PGF)IBA
02/2006
1Indomethacin (Indometacin)FDA LinkGeneric
02/2006
1Opioid Peptides (Opioid Peptide)IBA
02/2006
1N- (4- amino- 2- methylquinolin- 6- yl)- 2- (4- ethylphenoxymethyl)benzamideIBA
02/2006
1sarcalumeninIBA
09/2005
1Buprenorphine (Subutex)FDA LinkGeneric
11/2003
1Staphylococcal Protein A (A, Protein)IBA
10/2003
1Caffeine (No Doz)FDA LinkGeneric
10/2003

Therapy/Procedure

1Lasers (Laser)
07/2010
1Oral Administration
01/2008