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Luca Spiezia Selected Research

Factor V Deficiency

11/2013	Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation.
1/2010	Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms.
11/2008	Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.

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Luca Spiezia Research Topics

Disease

12	Thrombosis (Thrombus) 12/2015 - 10/2006
9	Venous Thrombosis (Deep-Vein Thrombosis) 04/2013 - 04/2003
7	Thrombophilia 12/2015 - 10/2003
6	Hemorrhage 12/2015 - 05/2008
5	Venous Thromboembolism 04/2013 - 04/2003
4	Neoplasms (Cancer) 07/2014 - 05/2011
3	Hemophilia A (Haemophilia) 12/2015 - 07/2009
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 06/2015 - 07/2011
3	Factor V Deficiency 11/2013 - 11/2008
2	Pulmonary Embolism 08/2014 - 05/2008
2	Protein S Deficiency (Deficiency, Protein S) 09/2010 - 04/2010
2	Conjunctivitis 01/2006 - 07/2003
1	Sensorineural Hearing Loss 03/2015
1	Obesity 03/2015
1	Overweight 01/2015
1	Shock 03/2014
1	Hemophilia B (Haemophilia B) 01/2012
1	Stroke (Strokes) 09/2011
1	Disease Susceptibility (Diathesis) 11/2008
1	Atrial Fibrillation 05/2008
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 04/2005
1	von Willebrand Diseases (von Willebrand's Disease) 07/2003
1	Rare Diseases (Rare Disease) 07/2003
1	Atherosclerosis 04/2003
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2003

Drug/Important Bio-Agent (IBA)

5	factor V LeidenIBA 12/2015 - 10/2012
5	Factor VIIa (Activated Factor VII)IBA 08/2012 - 06/2010
4	Protein SIBA 12/2015 - 09/2009
4	Prothrombin (Factor II)IBA 12/2015 - 04/2013
4	Thrombin FDA Link 01/2015 - 10/2006
3	AntibodiesIBA 06/2015 - 07/2009
3	Factor V (Coagulation Factor V)IBA 11/2013 - 11/2008
2	Protein CIBA 12/2015 - 09/2009
2	Glycoproteins (Glycoprotein)IBA 06/2015 - 06/2015
2	fibrin fragment D (D-dimer)IBA 06/2015 - 07/2011
2	Thromboplastin (Tissue Factor)IBA 01/2015 - 05/2011
2	Fibrinogen (Factor I)FDA Link 03/2014 - 07/2008
2	AnticoagulantsIBA 04/2013 - 07/2011
2	Factor IX (PTC)FDA LinkGeneric 04/2013 - 10/2009
2	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 07/2011 - 04/2010
2	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2010 - 11/2008
2	PlasminogenIBA 01/2006 - 07/2003
1	Immunoglobulin G (IgG)IBA 06/2015
1	beta 2-Glycoprotein I (Apolipoprotein H)IBA 06/2015
1	Cardiolipins (Cardiolipin)IBA 06/2015
1	Blood Coagulation Factors (Coagulation Factor)IBA 03/2015
1	Adenosine Monophosphate (AMP)IBA 01/2015
1	Annexin A5IBA 01/2015
1	ArsenicIBA 08/2014
1	Benzene (Benzole)IBA 08/2014
1	Carbon MonoxideIBA 08/2014
1	NickelIBA 08/2014
1	RNA (Ribonucleic Acid)IBA 11/2013
1	Blood Group Antigens (Blood Groups)IBA 04/2013
1	AntigensIBA 04/2013
1	antineoplaston A10 (A 10)IBA 01/2012
1	platelet factor VIBA 01/2010
1	Leucine (L-Leucine)FDA Link 10/2009
1	Arginine (L-Arginine)FDA Link 10/2009
1	Anti-Idiotypic AntibodiesIBA 09/2009
1	Factor VIII (Coagulation Factor VIII)IBA 07/2009
1	idraparinuxIBA 05/2008
1	Vitamin K FDA Link 05/2008
1	FibrinIBA 01/2006
1	Apolipoproteins AIBA 01/2006
1	Plasminogen Activator Inhibitor 1IBA 10/2003
1	von Willebrand FactorIBA 07/2003
1	Plasminogen Activators (Plasminogen Activator)IBA 04/2003
1	Oral ContraceptivesIBA 04/2003

Therapy/Procedure

1	Hematopoietic Stem Cell Transplantation 04/2005
1	Hypophysectomy 07/2003
1	Transplantation (Transplant Recipients) 04/2003