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Malcolm A Smith Selected Research

Heterologous Transplantation (Xenotransplantation)

11/2015Initial testing (stage 1) of the anti-microtubule agents cabazitaxel and docetaxel, by the pediatric preclinical testing program.
9/2015AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
7/2015Initial testing (stage 1) of the tubulin binding agent nanoparticle albumin-bound (nab) paclitaxel (Abraxane(®)) by the Pediatric Preclinical Testing Program (PPTP).
6/2015Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program.
3/2015Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia.
2/2015Synergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program.
1/2015Efficacy of CPX-351, (cytarabine:daunorubicin) liposome injection, against acute lymphoblastic leukemia (ALL) xenograft models of the Pediatric Preclinical Testing Program.
11/2014Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program.
10/2014Initial testing (stage 1) of glembatumumab vedotin (CDX-011) by the pediatric preclinical testing program.
9/2014Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.
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Malcolm A Smith Research Topics

Disease

74Neoplasms (Cancer)
12/2015 - 12/2002
23Sarcoma (Soft Tissue Sarcoma)
11/2015 - 03/2008
20Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
09/2015 - 01/2008
18Neuroblastoma
08/2015 - 03/2008
16Leukemia
09/2015 - 06/2008
16Rhabdomyosarcoma
07/2015 - 06/2008
14Osteosarcoma (Osteogenic Sarcoma)
07/2015 - 03/2008
9Glioblastoma (Glioblastoma Multiforme)
02/2014 - 03/2008
8Wilms Tumor (Wilm's Tumor)
11/2014 - 05/2008
5Rhabdoid Tumor (Rhabdoid Tumors)
07/2010 - 05/2008
4Alveolar Rhabdomyosarcoma
04/2013 - 03/2008
3Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
09/2015 - 09/2014
3Medulloblastoma
04/2013 - 03/2008
2Philadelphia Chromosome
09/2014 - 06/2008
2Brain Neoplasms (Brain Tumor)
09/2008 - 05/2008
1Weight Loss (Weight Reduction)
07/2015
1Sudden Infant Death (SID)
11/2014
1Disease Progression
08/2014
1Myeloid Leukemia (Leukemia, Myelocytic)
10/2012
1Hyperalgesia
10/2011
1Inflammation
10/2011
1Anoxia (Hypoxia)
09/2011
1Ependymoma
08/2011

Drug/Important Bio-Agent (IBA)

39N- propyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (PPTP)IBA
11/2015 - 12/2007
6Vincristine (Oncovin)FDA LinkGeneric
11/2015 - 12/2007
5Sirolimus (Rapamycin)FDA Link
05/2012 - 04/2008
4Janus KinasesIBA
02/2015 - 07/2010
4Phosphotransferases (Kinase)IBA
09/2014 - 06/2008
3Topotecan (Hycamtin)FDA LinkGeneric
11/2013 - 05/2010
2AntibodiesIBA
12/2015 - 05/2012
2TaxoidsIBA
11/2015 - 07/2015
2PR-104IBA
09/2015 - 09/2011
2Dexamethasone (Maxidex)FDA LinkGeneric
09/2015 - 01/2010
2PR-104AIBA
09/2015 - 09/2011
2Antimitotic AgentsIBA
07/2015 - 08/2013
2temozolomide (Temodar)FDA LinkGeneric
02/2015 - 05/2013
2MicroRNAs (MicroRNA)IBA
02/2015 - 09/2009
2AZD1480IBA
02/2015 - 11/2014
2Cytarabine (Cytosar-U)FDA LinkGeneric
01/2015 - 12/2010
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2014 - 10/2009
2ABT 263IBA
09/2014 - 06/2008
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2014 - 03/2008
2DNA (Deoxyribonucleic Acid)IBA
05/2013 - 03/2008
2Cisplatin (Platino)FDA LinkGeneric
04/2012 - 05/2008
2CytotoxinsIBA
04/2012 - 01/2010
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2012 - 12/2007
24- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
04/2012 - 03/2008
2Messenger RNA (mRNA)IBA
02/2012 - 09/2009
2aurora kinase (aurora A kinase)IBA
11/2011 - 07/2009
2MLN 8237IBA
11/2011 - 07/2010
2EWS-FLI1 fusion proteinIBA
12/2010 - 03/2008
2Proteasome Endopeptidase Complex (Proteasome)IBA
07/2009 - 01/2008
2Proteins (Proteins, Gene)IBA
07/2009 - 07/2008
1Protein Isoforms (Isoforms)IBA
12/2015
1docetaxel (Taxotere)FDA Link
11/2015
14- acetoxy- 13- ((3- ((tert- butoxycarbonyl)amino)- 2- hydroxy- 3- phenylpropanoyl)oxy)- 1- hydroxy- 7,10- dimethoxy- 9- oxo- 5,20- epoxytax- 11- en- 2- yl benzoateFDA Link
11/2015
1Mechlorethamine (Nitrogen Mustard)FDA Link
09/2015
1Asparaginase (Elspar)FDA Link
09/2015
1130-nm albumin-bound paclitaxelIBA
07/2015
1albumin-bound paclitaxelFDA Link
07/2015
1Carbon MonoxideIBA
01/2015
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2015
1Liposomes (Liposome)IBA
01/2015
1Daunorubicin (Cerubidine)FDA LinkGeneric
01/2015
1Adenosine Triphosphate (ATP)IBA
11/2014
1Angiogenesis InhibitorsIBA
11/2014
1glembatumumab vedotinIBA
10/2014
1RNA (Ribonucleic Acid)IBA
10/2014
1Transcription Factors (Transcription Factor)IBA
09/2014
1Biological Markers (Surrogate Marker)IBA
09/2014
12- (5,7- difluoro- 1,2,3,4- tetrahydronaphthalen- 3- ylamino)- N- (1- (2- methyl- 1- (neopentylamino)propan- 2- yl)- 1H- imidazol- 4- yl)pentanamideIBA
08/2014
1pixantrone (BBR 2778)IBA
05/2014
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
02/2014
1polo-like kinase 1IBA
01/2014
1BI 6727IBA
01/2014
12- (3- amino- 2- hydroxypropyl)hexacosahydro- 3- methoxy- 26- methyl- 20,27- bis(methylene)11,15- 18,21- 24,28- triepoxy- 7,9- ethano- 12,15- methano- 9H,15H- furo(3,2- i)furo(2',3'- 5,6)pyrano(4,3- b)(1,4)dioxacyclopentacosin- 5- (4H)- oneIBA
08/2013
1SGI 1776IBA
10/2012
1arsenic trioxide (Trisenox)FDA Link
10/2012
1pazopanibIBA
09/2012
1MK 2206IBA
09/2012
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
09/2012
1((1S,2S,4R)- 4- (4- ((1S)- 2,3- dihydro- 1H- inden- 1- ylamino)- 7H- pyrrolo(2,3- d)pyrimidin- 7- yl)- 2- hydroxycyclopentyl)methyl sulphamateIBA
08/2012
1(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA
07/2012
1KinesinIBA
06/2012
1Somatomedin Receptors (Somatomedin Receptor)IBA
05/2012
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
05/2012
12,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
05/2012
1(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA
02/2012
1lenalidomide (CC 5013)FDA Link
10/2011
1OxidoreductasesIBA
09/2011
1carbonyl reductase (NADPH)IBA
09/2011
1SpermineIBA
08/2011
1BMS 754807IBA
04/2011
1Etoposide (VP 16)FDA LinkGeneric
02/2011
1Melphalan (Alkeran)FDA LinkGeneric
02/2011

Therapy/Procedure

67Heterologous Transplantation (Xenotransplantation)
11/2015 - 12/2002
4Drug Therapy (Chemotherapy)
08/2015 - 07/2010
2Therapeutics
02/2015 - 07/2009
2Withholding Treatment
07/2008 - 06/2008
1Radiotherapy
05/2013