Koichi Shudo Selected Research

Retinoids

1/2017	Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.
2/2016	Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells.
8/2014	Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice.
3/2013	Synthetic retinoid Am80 results in improved exploratory and emotional behavior in the P8 substrain of senescence-accelerated mice.
2/2013	Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation.
10/2012	Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice.
5/2012	Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice.
1/2012	Tamibarotene: a candidate retinoid drug for Alzheimer's disease.
1/2011	A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice.
7/2009	Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

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Koichi Shudo Research Topics

Disease

7	Acute Promyelocytic Leukemia 01/2017 - 07/2009
5	Neoplasms (Cancer) 11/2016 - 01/2003
5	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 07/2009
4	Cerebral Hemorrhage 09/2016 - 01/2011
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/2015 - 01/2003
3	Infections 11/2016 - 11/2013
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 02/2009
3	Neuralgia (Stump Neuralgia) 07/2014 - 12/2012
3	Memory Disorders (Memory Loss) 01/2014 - 11/2004
2	Neutropenia 11/2016 - 02/2013
2	Neuroblastoma 01/2016 - 10/2015
2	Dizziness (Lightheadedness) 07/2014 - 01/2014
2	Sleepiness 07/2014 - 01/2014
2	Chronic Pain 01/2014 - 12/2012
2	Leukemia 01/2014 - 01/2003
2	Insulin Resistance 01/2013 - 10/2012
2	Hematoma 05/2012 - 01/2011
2	Atherosclerosis 07/2007 - 05/2006
2	Autoimmune Diseases (Autoimmune Disease) 06/2006 - 01/2003
1	Lung Neoplasms (Lung Cancer) 01/2017
1	Bacterial Infections (Bacterial Infection) 11/2016
1	Systemic Scleroderma (Systemic Sclerosis) 02/2016
1	Fibrosis (Cirrhosis) 02/2016
1	Pathologic Processes 02/2016
1	Optic Neuritis (Retrobulbar Neuritis) 08/2015
1	Pulmonary Emphysema 12/2014
1	Chronic Obstructive Pulmonary Disease (COPD) 12/2014
1	Neuroinflammatory Diseases 01/2014
1	Dementia (Dementias) 09/2013
1	Vasculitis (Vasculitides) 02/2013
1	Iron Overload 01/2013
1	Fatty Liver 10/2012
1	Non-alcoholic Fatty Liver Disease 10/2012
1	Hemorrhage 01/2011
1	Edema (Dropsy) 01/2011

Drug/Important Bio-Agent (IBA)

29	tamibaroteneIBA 01/2017 - 01/2003
21	RetinoidsIBA 01/2017 - 01/2003
10	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2017 - 10/2002
10	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 10/2015 - 07/2007
7	Therapeutic UsesIBA 09/2016 - 05/2012
5	Pharmaceutical PreparationsIBA 01/2017 - 01/2012
4	AcidsIBA 07/2014 - 10/2002
4	HX 630IBA 01/2014 - 01/2003
3	Pregabalin (Lyrica)FDA Link 07/2014 - 12/2012
3	gamma-Aminobutyric Acid (GABA)IBA 07/2014 - 12/2012
3	LigandsIBA 01/2014 - 10/2004
3	Benzoic Acid (Potassium Benzoate)FDA Link 02/2009 - 01/2003
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2016 - 02/2013
2	Interleukin-10 (Interleukin 10)IBA 02/2016 - 05/2006
2	Analgesics (Analgesic Drugs)IBA 07/2014 - 01/2014
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2014 - 12/2012
2	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2014 - 10/2004
2	Amyloid (Amyloid Fibrils)IBA 01/2014 - 07/2009
2	ProdrugsIBA 01/2013 - 12/2009
2	Collagenases (Collagenase)FDA Link 05/2012 - 01/2011
2	Scopolamine (Hyoscine)FDA Link 01/2012 - 11/2004
2	TAC 101IBA 11/2004 - 01/2003
1	Catechin (Z 7300)IBA 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	TeaIBA 01/2017
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2017
1	Complement System Proteins (Complement)IBA 11/2016
1	Chemokine CXCL2IBA 09/2016
1	Interleukin-4 (Interleukin 4)IBA 02/2016
1	Bleomycin (Blenoxane)FDA LinkGeneric 02/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2016
1	Interleukin-13IBA 02/2016
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2016
1	Interleukin-17 (Interleukin 17)IBA 02/2016
1	indium-bleomycinIBA 02/2016
1	Connective Tissue Growth FactorIBA 02/2016
1	Mitogen-Activated Protein KinasesIBA 10/2015
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 10/2015
1	Pancreatic Elastase (Elastase)IBA 12/2014
1	silagaba132IBA 07/2014
1	SiliconIBA 07/2014
1	Hypnotics and Sedatives (Sedatives)IBA 01/2014
1	Peptides (Polypeptides)IBA 01/2014
1	SolutionsIBA 01/2014
1	AmidesIBA 11/2013
1	Linezolid (Zyvox)FDA Link 11/2013
1	Vitamin A (Retinol)FDA LinkGeneric 09/2013
1	IronIBA 01/2013
1	Gabapentin (Neurontin)FDA LinkGeneric 12/2012
1	Aminobutyrates (Aminobutyric Acid)IBA 12/2012
1	Leptin ReceptorsIBA 10/2012
1	LeptinIBA 10/2012
1	Insulin (Novolin)FDA Link 10/2012
1	FructoseIBA 10/2012
1	CytokinesIBA 01/2012
1	Heme Oxygenase-1IBA 01/2011
1	3-nitrotyrosineIBA 01/2011
1	IT-M-07000IBA 12/2009
1	LipopolysaccharidesIBA 07/2009

Therapy/Procedure

6	Therapeutics 01/2014 - 10/2004
5	Oral Administration 05/2012 - 11/2005
3	Drug Therapy (Chemotherapy) 11/2016 - 02/2013
1	Cutaneous Administration 01/2014
1	Intravenous Administration 11/2013
1	Intraperitoneal Injections 02/2013