Mitchell L Shiffman Selected Research

Retreatment

10/2017	Sofosbuvir-velpatasvir with ribavirin for 24 weeks in hepatitis C virus patients previously treated with a direct-acting antiviral regimen.
11/2011	Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response.
6/2009	Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results.
1/2007	Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C.
12/2006	Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT-C trial.
5/2004	Retreatment of patients who do not respond to initial therapy for chronic hepatitis C.
1/2004	Management of patients with chronic hepatitis C virus infection and previous nonresponse.
11/2002	Retreatment of patients with chronic hepatitis C.

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Mitchell L Shiffman Research Topics

Disease

80	Fibrosis (Cirrhosis) 12/2021 - 01/2003
66	Chronic Hepatitis C 12/2021 - 09/2002
50	Infections 12/2021 - 09/2002
36	Hepatitis C 12/2019 - 01/2003
14	Liver Diseases (Liver Disease) 12/2021 - 05/2004
11	Inflammation (Inflammations) 01/2022 - 01/2004
10	Non-alcoholic Fatty Liver Disease 07/2021 - 06/2003
10	Anemia 11/2011 - 05/2004
8	End Stage Liver Disease 01/2020 - 08/2004
7	Pruritus (Itching) 01/2022 - 02/2004
7	Hepatocellular Carcinoma (Hepatoma) 02/2018 - 10/2004
7	Chronic Hepatitis B 09/2011 - 02/2003
6	Disease Progression 01/2022 - 11/2003
6	Liver Cirrhosis (Hepatic Cirrhosis) 12/2021 - 12/2008
6	Body Weight (Weight, Body) 05/2014 - 09/2002
5	Fatigue 07/2021 - 02/2006
5	Nausea 10/2017 - 05/2004
4	Cholestasis 01/2022 - 02/2004
4	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2022 - 08/2007
4	Hepatitis B 08/2012 - 04/2007
3	Portal Hypertension 12/2021 - 11/2015
3	Alcoholic Fatty Liver 01/2020 - 01/2019
3	Sclerosing Cholangitis 01/2019 - 08/2007
3	Headache (Headaches) 05/2013 - 05/2004
3	Viremia 09/2012 - 10/2004
3	Hemolytic Anemia 02/2012 - 01/2009
3	Hemolysis 11/2010 - 01/2009
3	Virus Diseases (Viral Diseases) 11/2003 - 09/2002
2	Hepatitis 12/2021 - 01/2006
2	Cicatrix (Scar) 01/2020 - 01/2020
2	Persistent Infection 01/2016 - 11/2003
2	Thrombocytopenia (Thrombopenia) 02/2014 - 11/2007
2	Acute Kidney Injury (Acute Renal Failure) 08/2012 - 08/2009
2	Chronic Kidney Failure (Chronic Renal Failure) 09/2011 - 04/2007
2	Neutropenia 07/2011 - 08/2008

Drug/Important Bio-Agent (IBA)

71	Ribavirin (Virazole)FDA LinkGeneric 12/2019 - 09/2002
36	InterferonsIBA 01/2017 - 01/2003
32	Antiviral Agents (Antivirals)IBA 12/2021 - 04/2004
24	RNA (Ribonucleic Acid)IBA 12/2016 - 01/2003
14	peginterferon alfa-2a (Pegasys)FDA Link 04/2014 - 09/2002
13	Alanine Transaminase (SGPT)IBA 01/2021 - 01/2003
12	SofosbuvirIBA 12/2019 - 02/2013
8	Interferon-alpha (Interferon Alfa)IBA 10/2014 - 07/2003
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2015
7	BilirubinIBA 12/2021 - 02/2004
5	sofosbuvir drug combination ledipasvirIBA 12/2021 - 05/2014
5	Protease Inhibitors (Protease Inhibitor)IBA 12/2015 - 05/2004
5	adefovir dipivoxil (Hepsera)FDA Link 09/2011 - 02/2003
4	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2022 - 10/2017
4	Alkaline PhosphataseIBA 01/2022 - 02/2004
4	selonsertibIBA 07/2021 - 11/2019
4	cilofexorIBA 07/2021 - 01/2019
4	CollagenIBA 01/2021 - 10/2018
4	Pharmaceutical PreparationsIBA 01/2020 - 04/2007
4	ledipasvirIBA 11/2018 - 05/2014
4	Ritonavir (Norvir)FDA Link 01/2017 - 05/2014
4	NucleotidesIBA 05/2014 - 01/2006
4	Hepatitis B e AntigensIBA 01/2011 - 02/2003
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 12/2021 - 12/2010
3	nasIBA 07/2021 - 12/2019
3	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 01/2019
3	3- (2- (2- tert- butylphenylaminooxalyl)aminopropionylamino)- 4- oxo- 5- (2,3,5,6- tetrafluorophenoxy)pentanoic acidIBA 01/2020 - 08/2007
3	CaspasesIBA 01/2020 - 08/2007
3	simtuzumabIBA 12/2019 - 10/2018
3	velpatasvirIBA 10/2017 - 12/2015
3	dasabuvirIBA 01/2017 - 05/2014
3	ombitasvirIBA 01/2017 - 05/2014
3	paritaprevirIBA 01/2017 - 05/2014
3	NucleosidesIBA 07/2014 - 05/2004
3	Tenofovir (Viread)FDA Link 08/2012 - 12/2008
3	taribavirin (viramidine)IBA 10/2010 - 04/2007
3	Epoetin Alfa (Epogen)FDA Link 06/2005 - 05/2004
2	seladelparIBA 01/2022 - 10/2017
2	glecaprevir and pibrentasvirIBA 11/2021 - 12/2019
2	Drug CombinationsIBA 07/2021 - 01/2021
2	firsocostatIBA 07/2021 - 01/2021
2	Cytidine Triphosphate (CTP)IBA 01/2020 - 01/2005
2	AntigensIBA 01/2020 - 01/2006
2	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2019 - 10/2018
2	daclatasvirIBA 01/2019 - 01/2017
2	AlbuminsIBA 11/2018 - 12/2016
2	Proton Pump InhibitorsIBA 12/2016 - 01/2016
2	SimeprevirIBA 08/2015 - 07/2014
2	Proteins (Proteins, Gene)FDA Link 07/2014 - 02/2004
2	eltrombopag FDA Link 02/2014 - 11/2007
2	Immunoglobulins (Immunoglobulin)IBA 08/2012 - 01/2008
2	Emtricitabine (Emtriva)FDA Link 08/2012 - 01/2006
2	hepatitis B hyperimmune globulinIBA 08/2012 - 01/2008
2	telaprevirIBA 02/2012 - 11/2011
2	ProdrugsIBA 10/2010 - 09/2009
2	AntibodiesIBA 09/2009 - 06/2005
2	peginterferon alfa-2b (Pegintron)FDA Link 08/2009 - 06/2005

Therapy/Procedure

58	Therapeutics 01/2021 - 01/2003
21	Liver Transplantation 01/2020 - 06/2003
9	Drug Tapering 04/2014 - 05/2004
8	Retreatment 10/2017 - 11/2002
6	Transplantation 05/2013 - 02/2003
4	Aftercare (After-Treatment) 12/2019 - 11/2003
2	Subcutaneous Injections 01/2019 - 10/2018
2	Highly Active Antiretroviral Therapy (HAART) 12/2010 - 05/2004