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Makoto Shibutani Selected Research

Fenbendazole

8/2010Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.
4/2010Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
5/2009Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
11/2008Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.

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Makoto Shibutani Research Topics

Disease

58Neoplasms (Cancer)
05/2015 - 01/2002
13Body Weight (Weight, Body)
01/2016 - 07/2007
10Hypothyroidism
03/2015 - 12/2007
10Carcinoma (Carcinomatosis)
03/2013 - 01/2002
4Hypertrophy
01/2011 - 02/2007
3Hyperplasia
05/2010 - 03/2005
2Colorectal Neoplasms (Colorectal Cancer)
05/2015 - 08/2012
2Microcephaly
05/2014 - 04/2014
2Inflammation
06/2012 - 04/2011
2IGA Glomerulonephritis (IGA Nephropathy)
06/2012 - 01/2011
2Necrosis
05/2012 - 01/2008
2Neuroendocrine Carcinoma
07/2011 - 09/2010
2Adenoma (Adenomas)
02/2010 - 12/2009
1Demyelinating Diseases (Demyelinating Disease)
05/2015
1Lymphoma (Lymphomas)
02/2015
1Edema
02/2015
1Nephritis
02/2014
1Infection
02/2014
1Chromosomal Instability (Chromosome Stability)
06/2013
1Fibrosis (Cirrhosis)
06/2012

Drug/Important Bio-Agent (IBA)

10Phenobarbital (Luminal)FDA Link
02/2014 - 07/2007
8Carbon MonoxideIBA
08/2014 - 02/2010
8Diethylnitrosamine (N-Nitrosodiethylamine)IBA
03/2012 - 07/2007
7PropylthiouracilFDA Link
01/2016 - 12/2007
7Piperonyl ButoxideFDA Link
08/2014 - 05/2009
7Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
02/2014 - 01/2011
6Methimazole (Thiamazole)FDA LinkGeneric
03/2015 - 12/2007
6Thioacetamide (Thioacetamid)IBA
11/2013 - 05/2009
6Glutathione Transferase (Glutathione S-Transferase)IBA
09/2012 - 05/2008
5isoquercitrinIBA
08/2014 - 02/2010
5indole-3-carbinolIBA
02/2014 - 01/2011
5SulfadimethoxineIBA
03/2013 - 04/2009
5Reactive Oxygen Species (Oxygen Radicals)IBA
03/2012 - 02/2010
5EnzymesIBA
01/2012 - 12/2008
4Keratins (Keratin)IBA
05/2015 - 02/2010
4Proteins (Proteins, Gene)IBA
01/2014 - 02/2004
4VimentinIBA
06/2013 - 06/2010
4FenbendazoleIBA
08/2010 - 11/2008
3TenascinIBA
12/2013 - 06/2012
3HormonesIBA
06/2013 - 07/2009
3nivalenolIBA
06/2012 - 01/2008
3Messenger RNA (mRNA)IBA
09/2011 - 12/2008
3Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
05/2010 - 07/2009
2tensins (tensin)IBA
08/2014 - 05/2009
2Transforming Growth Factors (Transforming Growth Factor)IBA
08/2014 - 08/2010
2Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
05/2014 - 04/2014
2Dihydrotachysterol (AT 10)IBA
04/2014 - 06/2013
2ParaffinIBA
02/2014 - 04/2006
2CarcinogensIBA
06/2013 - 06/2002
2Antithyroid Agents (Antithyroid Drugs)IBA
03/2013 - 12/2007
2diisopropanolnitrosamineIBA
03/2013 - 07/2009
2Orphenadrine (Disipal)FDA LinkGeneric
01/2013 - 01/2013
2Aminobutyric Acids (Aminobutyric Acid)IBA
10/2012 - 08/2011
2carminic acid (cochineal)IBA
06/2012 - 01/2012
2Immunoglobulin A (IgA)IBA
06/2012 - 01/2011
2Flutamide (Eulexin)FDA LinkGeneric
03/2012 - 09/2011
2Omeprazole (Esomeprazole)FDA LinkGeneric
01/2012 - 01/2012
2Chromogranin AIBA
07/2011 - 09/2010
2SDMIBA
05/2011 - 04/2011
2oxfendazoleIBA
02/2011 - 02/2010
2benzimidazoleIBA
02/2011 - 02/2010
2Triiodothyronine (Liothyronine)FDA LinkGeneric
01/2011 - 12/2009
2SynaptophysinIBA
09/2010 - 03/2009
2IronIBA
05/2010 - 11/2008
2CopperIBA
05/2010 - 07/2009
2Phosphotransferases (Kinase)IBA
05/2010 - 05/2009
2MetallothioneinIBA
04/2010 - 07/2009
2Transferrin Receptors (Transferrin Receptor)IBA
04/2010 - 11/2008
2Ceruloplasmin (Ferroxidase)IBA
04/2010 - 07/2009
2beta-NaphthoflavoneIBA
02/2010 - 06/2009
1CuprizoneIBA
05/2015
1AzoxymethaneIBA
05/2015
1MucinsIBA
05/2015
1Alcian BlueIBA
05/2015
1Periodic AcidIBA
05/2015
1HexachloropheneFDA LinkGeneric
02/2015
1Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
02/2015
1Thyroid HormonesIBA
08/2014
1Nuclear Proteins (Protein, Nuclear)IBA
04/2014
1Formaldehyde (Formol)FDA Link
02/2014
1RNA (Ribonucleic Acid)IBA
02/2014
1Cathepsin BIBA
12/2013
1GelatinasesIBA
12/2013
1Thioctic Acid (Lipoic Acid)IBA
09/2013
1alpha-benzoylamino-1,4-naphthoquinone (PPM 18)IBA
07/2013
1tetrabromobisphenol AIBA
06/2013
1hexabromocyclododecaneIBA
06/2013
1decabromobiphenyl ether (decabromodiphenyl ether)IBA
06/2013
1Flame Retardants (Fire Retardants)IBA
06/2013
1gamma-Aminobutyric Acid (GABA)IBA
10/2012
1calretininIBA
10/2012
1Cyclin-Dependent Kinase Inhibitor p16IBA
09/2012
1lac dyeIBA
06/2012
1SMTP 7IBA
06/2012
1CD44 AntigensIBA
06/2012

Therapy/Procedure

8Intraperitoneal Injections
01/2012 - 07/2007
2Aftercare (After-Treatment)
05/2015 - 04/2010
2Heterologous Transplantation (Xenotransplantation)
12/2013 - 12/2009
2Ovariectomy (Oophorectomy)
02/2010 - 01/2003
1Intravenous Injections
05/2015