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Christian Schnell Selected Research

vatalanib (PTK787)

3/2008Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeutics.
6/2006Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases.
8/2005PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo.
6/2005The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade.
3/2004Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis.

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Christian Schnell Research Topics

Disease

16Neoplasms (Cancer)
11/2015 - 03/2004
7Melanoma (Melanoma, Malignant)
01/2011 - 08/2005
4Neoplasm Metastasis (Metastasis)
03/2008 - 08/2005
2Breast Neoplasms (Breast Cancer)
07/2014 - 12/2009
2Colorectal Neoplasms (Colorectal Cancer)
06/2006 - 03/2004
1Acidosis
12/2011
1Pathologic Neovascularization
12/2011
1Urinary Bladder Neoplasms (Bladder Cancer)
10/2011
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2010
1Hypertension (High Blood Pressure)
11/2009
1Proteinuria
11/2009
1Body Weight (Weight, Body)
11/2009
1Necrosis
11/2005
1Leukemia
03/2004
1Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)
09/2002
1Inflammation
09/2002
1Infection
09/2002

Drug/Important Bio-Agent (IBA)

7Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2011 - 03/2004
5Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
03/2008 - 03/2004
5vatalanib (PTK787)IBA
03/2008 - 03/2004
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2008 - 03/2004
3glucuronyl glucosamine glycan sulfate (Vessel)IBA
12/2011 - 11/2005
3NVP BEZ235IBA
12/2009 - 07/2008
3Phosphotransferases (Kinase)IBA
04/2009 - 03/2004
2Sirolimus (Rapamycin)FDA Link
04/2009 - 07/2008
2Biological Markers (Surrogate Marker)IBA
06/2006 - 11/2005
1benthiocarb (Bolero)IBA
07/2014
1trastuzumab (Herceptin)FDA Link
07/2014
1Protons (Proton)IBA
12/2011
1everolimusFDA Link
01/2011
1Cystatin CIBA
11/2009
1N 30IBA
11/2009
1Dexamethasone (Maxidex)FDA LinkGeneric
11/2009
1Protein Kinases (Protein Kinase)IBA
04/2009
1ZSTK474IBA
04/2009
1Cyclin D1IBA
04/2009
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
04/2009
1CytotoxinsIBA
02/2009
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
07/2008
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
03/2008
1LigandsIBA
03/2008
1Blocking AntibodiesIBA
03/2008
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
03/2008
1PlatinumIBA
03/2008
1Lysosphingolipid ReceptorsIBA
01/2006
1fingolimod (FTY720)FDA Link
01/2006
1epothilone B (EPO906)IBA
11/2005
1ferumoxides (Feridex)FDA Link
08/2005
1gadoterate meglumineIBA
08/2005
1ferric oxide (iron oxide)IBA
08/2005
1tyrosine receptor (receptor, tyrosine)IBA
06/2005
1gefitinib (Iressa)FDA Link
06/2005
1PKI 166IBA
06/2005
1bevacizumabFDA Link
03/2004
1imatinib (Gleevec)FDA Link
03/2004
1LuciferasesIBA
09/2002
1Toll-Like Receptors (Toll-Like Receptor)IBA
09/2002

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
11/2015 - 10/2011
2Therapeutics
11/2015 - 05/2014
1Drug Therapy (Chemotherapy)
03/2008
1Aftercare (After-Treatment)
11/2005