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Veena Sangwan Selected Research

triptolide

6/2015Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F.
5/2015Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
1/2015Minnelide effectively eliminates CD133(+) side population in pancreatic cancer.
8/2014Sorafenib and triptolide as combination therapy for hepatocellular carcinoma.
6/2014Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
6/2014Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
11/2013Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
7/2013Minnelide reduces tumor burden in preclinical models of osteosarcoma.
7/2013Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.
4/2013Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity.
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Veena Sangwan Research Topics

Disease

12Neoplasms (Cancer)
06/2015 - 08/2010
11Pancreatic Neoplasms (Pancreatic Cancer)
06/2015 - 08/2010
4Shock
07/2013 - 09/2002
2Neoplasm Metastasis (Metastasis)
06/2015 - 05/2015
2Adenocarcinoma
07/2013 - 08/2010
1Colorectal Neoplasms (Colorectal Cancer)
06/2015
1Colonic Neoplasms (Colon Cancer)
06/2015
1Hepatocellular Carcinoma (Hepatoma)
08/2014
1Tics (Tic)
05/2014
1Osteosarcoma (Osteogenic Sarcoma)
07/2013
1Neuroblastoma
04/2013
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013
1Cholangiocarcinoma
06/2011
1Liver Failure
01/2006
1Weight Gain
01/2006

Drug/Important Bio-Agent (IBA)

14triptolideIBA
06/2015 - 08/2010
3Phosphotransferases (Kinase)IBA
06/2014 - 09/2002
2Proteins (Proteins, Gene)IBA
05/2015 - 05/2014
2Small Interfering RNA (siRNA)IBA
01/2012 - 06/2011
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
06/2015
1Transcription Factors (Transcription Factor)IBA
05/2015
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2015
1Caspase 3 (Caspase-3)IBA
05/2015
1Annexin A5IBA
05/2015
1sorafenib (BAY 43-9006)FDA Link
08/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014
1Peptide Initiation Factors (Initiation Factor)IBA
06/2014
1Inositol (Myoinositol)IBA
06/2014
1Sp1 Transcription FactorIBA
11/2013
1Molecular Chaperones (Chaperone, Molecular)IBA
07/2013
1MicroRNAs (MicroRNA)IBA
07/2013
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
07/2013
1NF-kappa B (NF-kB)IBA
04/2013
1Messenger RNA (mRNA)IBA
04/2013
1Apoptosis Regulatory ProteinsIBA
01/2013
1RNA (Ribonucleic Acid)IBA
01/2012
1Glycoproteins (Glycoprotein)IBA
01/2012
1Cathepsin BIBA
01/2012
1GO 201IBA
01/2012
1Insulin (Novolin)FDA Link
01/2006
1Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
01/2006
1Mitogen-Activated Protein KinasesIBA
11/2002
1Protein Kinases (Protein Kinase)IBA
09/2002

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
06/2015 - 10/2012
2Drug Therapy (Chemotherapy)
07/2013 - 08/2010
1Therapeutics
06/2015