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Hiromichi Sakai Selected Research

Diacylglycerol Kinase

10/2021The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis.
11/2019Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids.
1/2019Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells.
3/2016A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response.
1/2016Myristic Acid Enhances Diacylglycerol Kinase δ-Dependent Glucose Uptake in Myotubes.
1/2016Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior.
5/2015Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol.
7/2014Regulation of diacylglycerol kinase δ2 expression in C2C12 skeletal muscle cells by free fatty acids.
1/2013Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ.

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Hiromichi Sakai Research Topics

Disease

5Type 2 Diabetes Mellitus (MODY)
11/2019 - 07/2014
4Neoplasms (Cancer)
10/2021 - 11/2012
2Starvation
01/2018 - 01/2013
2Bipolar Disorder (Manic Depressive Psychosis)
01/2016 - 11/2012
1Alzheimer Disease (Alzheimer's Disease)
12/2021
1Metabolic Diseases (Metabolic Disease)
11/2021
1Glioblastoma (Glioblastoma Multiforme)
10/2021
1Melanoma (Melanoma, Malignant)
10/2021
1Autistic Disorder (Autism)
01/2020
1Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
01/2020
1Schizophrenia (Dementia Praecox)
01/2020
1Parkinson Disease (Parkinson's Disease)
01/2018
1Hypertension (High Blood Pressure)
12/2017
1Hyperlipidemias (Hyperlipidemia)
12/2017
1Uterine Cervical Neoplasms (Cancer of the Cervix)
03/2016
1Hepatocellular Carcinoma (Hepatoma)
03/2016
1Mania (Manias)
01/2016
1Carcinogenesis
05/2015
1Neuroblastoma
01/2013
1Hypospadias
11/2012
1Seizures (Absence Seizure)
11/2012
1Guillain-Barre Syndrome
04/2012
1Adenocarcinoma of Lung
07/2007

Drug/Important Bio-Agent (IBA)

9Diacylglycerol KinaseIBA
10/2021 - 01/2013
4Glucose (Dextrose)FDA LinkGeneric
11/2019 - 11/2012
3IsoenzymesIBA
01/2019 - 03/2016
2PlasmalogensIBA
12/2021 - 11/2021
1phosphatidal ethanolaminesIBA
12/2021
1Glycerophospholipids (Phosphoglycerides)IBA
12/2021
1PKC-3 proteinIBA
10/2021
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
10/2021
1Sirolimus (Rapamycin)FDA Link
10/2021
1Serotonin (5 Hydroxytryptamine)IBA
01/2020
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
01/2020
1Monounsaturated Fatty AcidsIBA
11/2019
1Phosphatidic Acids (Phosphatidic Acid)IBA
11/2019
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
11/2019
1Fatty Acids (Saturated Fatty Acids)IBA
11/2019
1EnzymesIBA
11/2019
1Carrier Proteins (Binding Protein)IBA
01/2018
1SynucleinsIBA
01/2018
1Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2018
1SugarsIBA
12/2017
1SaltsIBA
12/2017
1Pharmaceutical PreparationsIBA
03/2016
1Interleukin-2 (IL2)IBA
03/2016
1LithiumIBA
01/2016
1Phosphotransferases (Kinase)IBA
09/2014
1DiglyceridesIBA
09/2014
1Messenger RNA (mRNA)IBA
01/2013
1Proteins (Proteins, Gene)FDA Link
01/2013
1GangliosidesIBA
04/2012
1Rabies Vaccines (Rabies Vaccine)FDA Link
04/2012
1LipidsIBA
07/2007

Therapy/Procedure

1Therapeutics
01/2020