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Erik Sahai Selected Research

Actomyosin

1/2016Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
6/2013Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
8/2011ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.
1/2011Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.
8/2006ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.

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Erik Sahai Research Topics

Disease

26Neoplasms (Cancer)
01/2016 - 02/2002
11Neoplasm Metastasis (Metastasis)
01/2016 - 01/2006
7Melanoma (Melanoma, Malignant)
01/2016 - 10/2008
6Carcinoma (Carcinomatosis)
03/2013 - 07/2003
3Breast Neoplasms (Breast Cancer)
01/2015 - 11/2009
2Inflammation
09/2015 - 08/2011
1Anoxia (Hypoxia)
10/2015
1Autoimmune Diseases (Autoimmune Disease)
09/2015
1Colorectal Neoplasms (Colorectal Cancer)
09/2015
1Cysts
02/2014
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2013
1Glioblastoma (Glioblastoma Multiforme)
02/2012
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2011
1Hypopigmentation (Hypomelanosis)
10/2009
1Myotonic Dystrophy (Dystrophia Myotonica)
12/2007
1Residual Neoplasm
06/2007
1Ovarian Neoplasms (Ovarian Cancer)
06/2007
1Polyploidy
06/2007

Drug/Important Bio-Agent (IBA)

5ActomyosinIBA
01/2016 - 08/2006
5Phosphotransferases (Kinase)IBA
09/2015 - 07/2003
4CollagenIBA
01/2016 - 01/2005
3rho-Associated KinasesIBA
01/2016 - 01/2007
3Carbon MonoxideIBA
10/2015 - 01/2015
3Small Interfering RNA (siRNA)IBA
02/2014 - 02/2012
3Transforming Growth Factor beta (TGF-beta)IBA
05/2010 - 10/2009
3Epidermal Growth Factor (EGF)IBA
12/2008 - 06/2005
3Proteins (Proteins, Gene)IBA
10/2007 - 02/2002
3rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
01/2007 - 02/2002
2GTP Phosphohydrolases (GTPases)IBA
02/2012 - 10/2008
2Transcription Factors (Transcription Factor)IBA
01/2011 - 03/2009
2Myosins (Myosin)IBA
02/2008 - 08/2006
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2006 - 06/2005
1AntioxidantsIBA
01/2016
1Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
10/2015
1Myosin Type IIIBA
10/2015
1Dinoprostone (PGE2)FDA Link
09/2015
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
09/2015
1PLX 4720IBA
04/2015
1protein kinase C lambdaIBA
02/2014
1Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
02/2014
1Cadherins (E-Cadherin)IBA
05/2013
1Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)IBA
05/2013
1Nonsense Codon (Nonsense Mutation)IBA
03/2013
1AgarIBA
03/2013
1Biological Markers (Surrogate Marker)IBA
01/2013
1GelsIBA
02/2012
1CytokinesIBA
08/2011
1discoidin receptorIBA
01/2011
1myocardinIBA
03/2009
1Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
10/2008
1IntegrinsIBA
12/2007
1Myosin Light Chains (Myosin Essential Light Chain)IBA
12/2007
1Carrier Proteins (Binding Protein)IBA
12/2007
1Paclitaxel (Taxol)FDA LinkGeneric
06/2007
1CytotoxinsIBA
06/2007
1myosin light chain 2IBA
01/2007
1Metalloproteases (Metalloproteinases)IBA
08/2006
1Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA
06/2005
1Macrophage Colony-Stimulating FactorIBA
06/2005
1First StepIBA
02/2005
1Cyan Fluorescent ProteinIBA
01/2005
1Estrogens (Estrogen)FDA Link
12/2004
1HormonesIBA
12/2004
1Messenger RNA (mRNA)IBA
12/2004
1Complementary DNA (cDNA)IBA
12/2004
1Actins (F Actin)IBA
12/2004

Therapy/Procedure

2Heterologous Transplantation (Xenotransplantation)
03/2013 - 06/2007
1Intradermal Injections
06/2015
1Drug Therapy (Chemotherapy)
06/2007