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Pierre Rustin Selected Research

Cytochrome-c Oxidase Deficiency

1/2015Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies.
4/2014Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.
12/2009The alternative oxidase, a tool for compensating cytochrome c oxidase deficiency in human cells.
4/2009Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.

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Pierre Rustin Research Topics

Disease

10Paraganglioma (Paragangliomas)
05/2014 - 10/2002
9Neoplasms (Cancer)
05/2014 - 01/2002
8Mitochondrial Diseases (Mitochondrial Disease)
04/2014 - 09/2002
8Friedreich Ataxia (Friedreich's Ataxia)
01/2013 - 04/2002
5Pheochromocytoma
05/2014 - 01/2005
4Cytochrome-c Oxidase Deficiency
01/2015 - 04/2009
4Anoxia (Hypoxia)
01/2015 - 11/2005
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2013 - 05/2004
3Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
03/2012 - 01/2008
3Optic Atrophy
01/2012 - 01/2002
3Ataxia (Dyssynergia)
01/2009 - 04/2003
3Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
08/2003 - 06/2003
2Mental Retardation (Idiocy)
06/2013 - 02/2009
2Heart Diseases (Heart Disease)
01/2010 - 05/2004
2Cardiomyopathies (Cardiomyopathy)
04/2009 - 05/2004
2Disease Progression
01/2009 - 01/2008
2Hypersensitivity (Allergy)
01/2009 - 06/2007
2Hypoglycemia (Reactive Hypoglycemia)
01/2006 - 06/2005
2Imperforate Anus
01/2006 - 08/2003
1Myotonic Dystrophy (Dystrophia Myotonica)
01/2015
1Ketosis
08/2013
1Hyperglycemia
08/2013
1Hirschsprung Disease (Hirschsprung's Disease)
06/2013
1Neuroendocrine Tumors (Neuroendocrine Tumor)
06/2013
1Ganglion Cysts (Ganglion)
12/2012
1Pituitary Neoplasms (Pituitary Adenoma)
03/2012
1Seminoma
03/2012
1Carcinoma (Carcinomatosis)
03/2012
1Blindness (Hysterical Blindness)
01/2012
1Leiomyoma (Uterine Fibroids)
04/2011
1Renal Cell Carcinoma (Grawitz Tumor)
04/2011
1Dwarfism
02/2009
1Neuroblastoma
01/2008
1Insulin Resistance
11/2007
1Sideroblastic Anemia
08/2006
1Lymphocytosis
03/2006
1Esophageal Fistula
01/2006
1Failure to Thrive
01/2006
1Esophageal Atresia
01/2006
1Liver Diseases (Liver Disease)
01/2006
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
12/2005
1Atrophy
12/2005
1Interstitial Nephritis (Tubulointerstitial Nephritis)
09/2005

Drug/Important Bio-Agent (IBA)

11Succinate Dehydrogenase (Fumarate Reductase)IBA
05/2014 - 01/2002
7EnzymesIBA
04/2014 - 09/2003
6alternative oxidaseIBA
01/2015 - 04/2009
6frataxinIBA
01/2013 - 05/2004
5Fumarate Hydratase (Fumarase)IBA
05/2014 - 01/2005
5Proteins (Proteins, Gene)IBA
08/2010 - 10/2002
5IronIBA
01/2009 - 05/2004
4Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA
08/2013 - 07/2003
3Insulin (Novolin)FDA Link
08/2013 - 06/2007
3SulfurIBA
01/2009 - 01/2008
3idebenoneIBA
05/2004 - 04/2002
2Transcription Factors (Transcription Factor)IBA
01/2015 - 10/2010
2Superoxides (Superoxide)IBA
01/2015 - 01/2013
2Retinaldehyde (Retinal)IBA
01/2012 - 08/2003
2Apoptosis Inducing FactorIBA
01/2012 - 12/2005
2Mitochondrial Proteins (Mitochondrial Protein)IBA
01/2009 - 05/2004
2Lactic AcidFDA LinkGeneric
01/2006 - 06/2005
2Electron Transport Complex I (NADH-CoQ Reductase)IBA
06/2003 - 01/2003
1Metformin (Glucophage)FDA LinkGeneric
01/2015
1Cytochromes c1 (Cytochrome c1)IBA
08/2013
1Goldberg-Shprintzen megacolon syndromeIBA
06/2013
1neuroglobinIBA
12/2012
1Small Interfering RNA (siRNA)IBA
12/2012
1Growth Hormone (Somatotropin)IBA
03/2012
1Messenger RNA (mRNA)IBA
01/2012
1DNA (Deoxyribonucleic Acid)IBA
01/2012
1hereditary Leiomyomatosis and renal cell cancerIBA
04/2011
1Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
10/2010
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2010
1Proline (L-Proline)FDA Link
10/2010
1OxygenIBA
10/2010
1Proteasome Endopeptidase Complex (Proteasome)IBA
10/2010
15- (6- chloro- 2,4- dioxo- 1,3,4,10- tetrahydro- 2H- 9- oxa- 1,3- diazaanthracen- 10- yl)pyrimidine- 2,4,6- trioneIBA
01/2010
1GossypolIBA
01/2010
1chelerythrineIBA
01/2010
1BH3 Interacting Domain Death Agonist ProteinIBA
01/2010
1Cytochromes c (Cytochrome c)IBA
01/2010
1PeptidesIBA
01/2010
1ABT-737IBA
01/2010
1CytochromesIBA
12/2009
1Heme (Haem)IBA
12/2009
1Electron Transport Complex IV (Cytochrome c Oxidase)IBA
04/2009
1chlorfenethol (DMC)IBA
02/2009
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
01/2008
1deferiprone (CP20)IBA
01/2008
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2008
1imatinib (Gleevec)FDA Link
01/2008
1Aconitate Hydratase (Aconitase)IBA
01/2008
1Glucose (Dextrose)FDA LinkGeneric
11/2007
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
06/2007
1Mitochondrial DNA (mtDNA)IBA
08/2006
1InterferonsIBA
03/2006
1VATER associationIBA
01/2006
1Succinic Acid (Succinate)IBA
11/2005
1Pyruvic Acid (Pyruvate)IBA
09/2005
1OxidoreductasesIBA
09/2005

Therapy/Procedure

1Adrenalectomy
03/2012