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Richard J Roman Selected Research

20-hydroxy-5,8,11,14-eicosatetraenoic acid

10/2015Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury.
3/2015Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.
1/2015Cytochrome P450 eicosanoids in hypertension and renal disease.
9/2014Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats.
7/201320-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries.
4/2013Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles.
7/201220-HETE-producing enzymes are up-regulated in human cancers.
5/2012Role of 20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats.
4/2012Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor.
3/2012Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.
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Richard J Roman Research Topics

Disease

27Hypertension (High Blood Pressure)
03/2015 - 01/2002
11Proteinuria
07/2015 - 09/2002
6Ischemia
10/2015 - 03/2008
6Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
10/2006 - 04/2002
5Reperfusion Injury
10/2015 - 08/2005
5Brain Ischemia (Cerebral Ischemia)
04/2012 - 05/2006
4Anoxia (Hypoxia)
04/2012 - 08/2002
3Diabetic Nephropathies (Diabetic Nephropathy)
12/2015 - 06/2013
3Polycystic Kidney Diseases (Polycystic Kidney Disease)
01/2015 - 10/2008
3Neoplasms (Cancer)
07/2012 - 04/2006
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
05/2009 - 12/2008
3Stroke (Strokes)
12/2008 - 07/2005
3Intracranial Vasospasm
10/2006 - 07/2005
2Hyperglycemia
07/2015 - 06/2013
2Kidney Diseases (Kidney Disease)
01/2015 - 08/2005
2Fibrosis (Cirrhosis)
07/2012 - 09/2002
2Cysts
03/2009 - 10/2008
2Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I)
03/2009 - 10/2008
2Glioma (Gliomas)
10/2008 - 11/2005
2Hyperemia
08/2008 - 12/2002
2Toxemia
08/2005 - 01/2002
2Uremia
08/2005 - 01/2002
1Body Weight (Weight, Body)
06/2014
1Neointima
07/2013
1Hyperplasia
07/2013
1Necrosis
06/2013
1Ovarian Neoplasms (Ovarian Cancer)
07/2012
1Acute Kidney Injury (Acute Renal Failure)
01/2011
1HIV Infections (HIV Infection)
07/2010
1Hyperlipidemias (Hyperlipidemia)
07/2010
1Adenocarcinoma
10/2009
1Carcinoma (Carcinomatosis)
10/2009
1Hyperoxaluria
08/2009
1Kidney Calculi (Kidney Stone)
08/2009
1Cystic Kidney Diseases (Cystic Kidney Disease)
10/2008
1Septic Shock (Toxic Shock Syndrome)
09/2008
1Lung Diseases (Lung Disease)
04/2006
1Gliosarcoma
04/2006
1Anemia
01/2006
1Diabetes Insipidus
12/2005
1Hemorrhage
11/2005
1Heart Diseases (Heart Disease)
08/2005
1Cerebral Hemorrhage
07/2005

Drug/Important Bio-Agent (IBA)

4520-hydroxy-5,8,11,14-eicosatetraenoic acidIBA
10/2015 - 01/2002
10Arachidonic Acid (Vitamin F)IBA
07/2012 - 03/2004
9Alkane 1-Monooxygenase (Alkane 1 Monooxygenase)IBA
10/2015 - 02/2005
8Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
01/2015 - 04/2003
5EnzymesIBA
07/2012 - 04/2003
4SodiumIBA
06/2014 - 03/2009
4AcidsIBA
06/2011 - 12/2002
4Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2008 - 08/2002
3CreatinineIBA
10/2015 - 12/2007
3Hydroxyeicosatetraenoic Acids (HETE)IBA
10/2014 - 04/2005
3formamidine (formamidinium)IBA
03/2009 - 11/2005
3N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamideIBA
06/2006 - 07/2005
2Streptozocin (Streptozotocin)FDA Link
12/2015 - 07/2015
2Lisinopril (Prinivil)FDA LinkGeneric
07/2015 - 06/2013
2EicosanoidsIBA
01/2015 - 10/2014
2Insulin (Novolin)FDA Link
10/2013 - 06/2013
2Hemoglobins (Hemoglobin)IBA
05/2009 - 01/2006
2NG-Nitroarginine Methyl Ester (L-NAME)IBA
12/2007 - 05/2005
2Adenosine Triphosphate (ATP)IBA
01/2006 - 08/2002
2formamideIBA
11/2005 - 07/2005
2Transforming Growth Factor beta (TGF-beta)IBA
04/2005 - 09/2002
1salicylhydroxamic acid (SHAM)IBA
06/2014
1Type 3 Melanocortin ReceptorIBA
02/2014
1LeptinIBA
02/2014
1Glucose (Dextrose)FDA LinkGeneric
06/2013
1fasudil (AT 877)IBA
11/2012
1Messenger RNA (mRNA)IBA
07/2012
1Hydrochlorothiazide (Esidrix)FDA LinkGeneric
07/2012
1Antihypertensive Agents (Antihypertensives)IBA
07/2012
1Diltiazem (Cardizem)FDA LinkGeneric
07/2012
1Captopril (Capoten)FDA LinkGeneric
07/2012
1Proteins (Proteins, Gene)IBA
04/2012
1AndrogensIBA
04/2011
1Caspase 3 (Caspase-3)IBA
12/2010
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2010
1Ritonavir (Norvir)FDA Link
07/2010
1Triglycerides (Triacylglycerol)IBA
07/2010
1CholesterolIBA
07/2010
1Protease Inhibitors (Protease Inhibitor)IBA
07/2010
1Calcium OxalateIBA
08/2009
1Hydroxyproline (4 Hydroxyproline)IBA
08/2009
1PolymersIBA
05/2009
1OxygenIBA
05/2009
1Endothelins (Endothelin)IBA
05/2009
1Glycine (Aminoacetic Acid)FDA LinkGeneric
03/2009
1ReninIBA
12/2007
1tebufenozide (Mimic)IBA
10/2006
1Tissue Plasminogen Activator (Alteplase)FDA Link
05/2006
1cytochrome P-450 CYP4A2 (rat)IBA
04/2006
1ethylene diurea (EDU)IBA
04/2006
1Prostaglandins A (PGA)IBA
04/2006
1CytochromesIBA
12/2005
1Fenofibrate (CiL)FDA LinkGeneric
04/2005

Therapy/Procedure

1Denervation
02/2014
1Sodium-Restricted Diet (Diet, Sodium Restricted)
04/2011
1Homologous Transplantation (Allograft)
12/2010
1Reducing Diet
10/2007