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Eleanor Rogan Selected Research

catechol (pyrocatechol)

4/2014The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.
2/2012Mechanism of DNA depurination by carcinogens in relation to cancer initiation.
12/2011Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease.
3/2009Mechanism of metabolic activation and DNA adduct formation by the human carcinogen diethylstilbestrol: the defining link to natural estrogens.
2/2009Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects.
11/2006Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture.
8/2006Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention.
1/2006The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity.
1/2005Tamoxifen versus aromatase inhibitors for breast cancer prevention.
1/2005Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3',4'-quinone. Implications for mutagenic activity.
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Eleanor Rogan Research Topics

Disease

17Neoplasms (Cancer)
12/2014 - 01/2004
7Breast Neoplasms (Breast Cancer)
04/2014 - 01/2005
2Prostatic Neoplasms (Prostate Cancer)
04/2014 - 11/2006
2Parkinson Disease (Parkinson's Disease)
12/2011 - 11/2006
2Neurodegenerative Diseases (Neurodegenerative Disease)
11/2006 - 01/2004
1Ovarian Neoplasms (Ovarian Cancer)
04/2014
1Non-Hodgkin Lymphoma (Lymphosarcoma)
04/2014
1Papilloma (Papillomatosis)
04/2014
1Leukemia
11/2006

Drug/Important Bio-Agent (IBA)

14Estrogens (Estrogen)FDA Link
12/2014 - 01/2005
11catechol (pyrocatechol)IBA
04/2014 - 01/2004
8QuinonesIBA
04/2014 - 01/2004
6DNA AdductsIBA
04/2014 - 11/2006
6DNA (Deoxyribonucleic Acid)IBA
04/2014 - 01/2005
5Estradiol (Estrace)FDA LinkGeneric
03/2009 - 01/2005
3Biological Markers (Surrogate Marker)IBA
04/2014 - 08/2006
3naphthaleneIBA
10/2009 - 11/2006
3Catechol EstrogensIBA
04/2007 - 01/2005
3Estradiol Congeners (Synthetic Estrogens)IBA
02/2007 - 01/2005
2Diethylstilbestrol (Stilbestrol)FDA Link
12/2014 - 11/2006
2HormonesIBA
12/2007 - 01/2006
2Estrone (Folliculin)FDA Link
04/2007 - 01/2005
2Benzene (Benzole)IBA
02/2007 - 11/2006
2Estrogen Receptor alphaIBA
08/2006 - 01/2005
1allyl sulfideIBA
12/2014
1amsonic acid (DAS)IBA
12/2014
1dibenzo(a,l)pyreneIBA
04/2014
1EnzymesIBA
04/2014
1resveratrolIBA
04/2014
1anthraceneIBA
04/2014
1MethylcholanthreneIBA
04/2014
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
04/2014
1Acetylcysteine (Siran)FDA LinkGeneric
04/2014
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2014
1Benzo(a)pyreneIBA
04/2014
1RNA (Ribonucleic Acid)IBA
02/2012
1CarcinogensIBA
02/2012
1Aromatic HydrocarbonsIBA
02/2012
1dopamine quinoneIBA
12/2011
11-naphthol (alpha-naphthol)IBA
10/2009
11,2-dihydroxynaphthaleneIBA
10/2009
11,2-naphthoquinoneIBA
10/2009
1GuanineIBA
02/2009
1AdenineFDA LinkGeneric
02/2009
1HexestrolIBA
11/2006
1Dopamine (Intropin)FDA LinkGeneric
11/2006
1CatecholsIBA
11/2006
1AndrogensIBA
01/2006
1estradiol-2,3-O-quinoneIBA
01/2006
1estradiol-3,4-quinoneIBA
01/2006
1Aromatase InhibitorsIBA
01/2005
1TamoxifenFDA LinkGeneric
01/2005
1Estrogen Receptor Modulators (Antiestrogen)IBA
01/2005

Therapy/Procedure

1Ovariectomy (Oophorectomy)
02/2009