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Danny Rischin Selected Research

tirapazamine (SR 4233)

10/2015Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.
2/2014Correlation of p16 status, hypoxic imaging using [18F]-misonidazole positron emission tomography and outcome in patients with loco-regionally advanced head and neck cancer.
6/2013Treatment response in the neck: p16+ versus p16- oropharyngeal cancer.
3/2012Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer.
9/2010Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial.
7/2010Phase 1 study of tirapazamine in combination with radiation and weekly cisplatin in patients with locally advanced cervical cancer.
6/2010Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02.
5/2006Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02.
12/2005Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent.
1/2005Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).

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Danny Rischin Research Topics

Disease

26Neoplasms (Cancer)
01/2015 - 01/2002
17Head and Neck Neoplasms (Head and Neck Cancer)
05/2015 - 03/2004
12Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2014 - 03/2004
12Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2013 - 01/2003
11Anoxia (Hypoxia)
10/2015 - 12/2004
6Carcinoma (Carcinomatosis)
03/2015 - 06/2002
5Ovarian Neoplasms (Ovarian Cancer)
11/2013 - 05/2004
4Neutropenia
05/2013 - 04/2002
4Neoplasm Metastasis (Metastasis)
02/2011 - 01/2003
3Merkel Cell Carcinoma
11/2008 - 12/2003
2Disease Progression
09/2012 - 10/2010
2Lung Neoplasms (Lung Cancer)
09/2012 - 10/2010
2Thyroid Neoplasms (Thyroid Cancer)
01/2012 - 06/2008
2Chronic Hepatitis B
08/2011 - 05/2011
2Oropharyngeal Neoplasms
06/2011 - 09/2010
2Thrombosis (Thrombus)
10/2009 - 06/2002
2Unknown Primary Neoplasms
05/2005 - 02/2003
1Teratoma (Teratoid Tumor)
08/2015
1Prostatic Neoplasms (Prostate Cancer)
03/2015
1Pneumonia (Pneumonitis)
01/2015
1Uterine Cervical Neoplasms (Cancer of the Cervix)
02/2013
1Infection
08/2011
1Breast Neoplasms (Breast Cancer)
08/2011
1Hepatitis B
05/2011
1Hypercalcemia (Milk Alkali Syndrome)
04/2011
1Clear Cell Adenocarcinoma
04/2011
1Diarrhea
10/2010
1Exanthema (Rash)
10/2010
1Squamous Cell Neoplasms (Squamous Cell Cancer)
09/2010
1Pulmonary Embolism
07/2010
1Pain (Aches)
10/2009
1Neuroendocrine Tumors (Neuroendocrine Tumor)
10/2009
1Necrosis
10/2009
1Hemorrhage
04/2009
1Neuroendocrine Carcinoma
12/2008
1Small Cell Carcinoma
12/2008

Drug/Important Bio-Agent (IBA)

10tirapazamine (SR 4233)IBA
10/2015 - 01/2005
10Cisplatin (Platino)FDA LinkGeneric
02/2014 - 04/2002
7Fluorouracil (Carac)FDA LinkGeneric
02/2014 - 04/2002
7Carboplatin (JM8)FDA LinkGeneric
02/2013 - 06/2002
5Epidermal Growth Factor Receptor (EGF Receptor)IBA
06/2011 - 01/2002
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2010 - 06/2003
4gefitinib (Iressa)FDA Link
04/2009 - 01/2002
3Cyclin-Dependent Kinase Inhibitor p16IBA
03/2012 - 06/2011
3PlatinumIBA
04/2011 - 05/2004
2MisonidazoleIBA
02/2014 - 05/2006
2DNA (Deoxyribonucleic Acid)IBA
01/2014 - 04/2011
2erlotinib (CP 358,774)FDA Link
09/2012 - 10/2010
2InterleukinsIBA
03/2012 - 04/2011
2sunitinib (Sutent)FDA Link
04/2011 - 06/2008
2Etoposide (VP 16)FDA LinkGeneric
11/2008 - 12/2003
2CytotoxinsIBA
01/2007 - 12/2004
2fluoromisonidazoleIBA
05/2006 - 12/2005
1EnzymesIBA
10/2015
1ProdrugsIBA
10/2015
1TH 302IBA
10/2015
1Biological Markers (Surrogate Marker)IBA
10/2015
1alpha-Fetoproteins (AFP)IBA
08/2015
1abirateroneIBA
03/2015
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
03/2015
1gemcitabineFDA Link
01/2015
1CyclinsIBA
11/2013
1fluoroazomycin arabinosideIBA
08/2013
1Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA
06/2013
1Midazolam (Versed)FDA LinkGeneric
05/2012
1Focal Adhesion Protein-Tyrosine KinasesIBA
05/2012
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
03/2012
1Interleukin-8 (Interleukin 8)IBA
03/2012
1medullary Thyroid cancerIBA
01/2012
1N- (4- bromo- 2- fluorophenyl)- 6- methoxy- 7- ((1- methylpiperidin- 4- yl)methoxy)quinazolin- 4- amine (ZD6474)IBA
01/2012
1OsteopontinIBA
01/2012
1CreatinineIBA
10/2011
1Surface Antigens (Surface Antigen)IBA
05/2011
1Interleukin-6 (Interleukin 6)IBA
04/2011
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
04/2011
1Nasopharyngeal carcinomaIBA
02/2011
1pazopanibIBA
10/2010
1Angiogenesis InhibitorsIBA
10/2010
1TransferasesIBA
07/2010
1Alanine (L-Alanine)FDA Link
07/2010
1PR-104IBA
03/2010
1Mechlorethamine (Nitrogen Mustard)FDA Link
03/2010
1PR-104AIBA
03/2010
1carbonyl reductase (NADPH)IBA
03/2010
1pentetreotide (OctreoScan)FDA Link
10/2009
1Somatostatin Receptors (Somatostatin Receptor)IBA
10/2009
1Octreotide (Sandostatin)FDA LinkGeneric
10/2009
1Methotrexate (Mexate)FDA LinkGeneric
04/2009
1Sinonasal undifferentiated carcinomaIBA
12/2008

Therapy/Procedure

26Radiotherapy
05/2015 - 06/2002
17Drug Therapy (Chemotherapy)
01/2015 - 04/2002
2Adjuvant Chemotherapy
08/2011 - 12/2003
2Catheters
10/2009 - 06/2002
1Anesthesia
03/2013
1Molecular Targeted Therapy
01/2012
1Heterologous Transplantation (Xenotransplantation)
03/2010
1Neck Dissection (Radical Neck Dissection)
02/2010
1Nutritional Support (Artificial Feeding)
07/2009
1Gastrostomy
07/2009
1Enteral Nutrition (Feeding, Tube)
07/2009