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Roger R Reddel Selected Research

Telomerase (Telomerase Reverse Transcriptase)

6/2015A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.
7/2014Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A.
1/2013Alternative lengthening of telomeres: remodeling the telomere architecture.
6/2012Cancer. Cancer and telomeres--an ALTernative to telomerase.
1/2012Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.
1/2012Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
12/2011Normal mammalian cells negatively regulate telomere length by telomere trimming.
10/2011MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region.
9/2011Telomerase activity in pleural malignant mesotheliomas.
1/2011HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.
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Roger R Reddel Research Topics

Disease

44Neoplasms (Cancer)
06/2015 - 01/2002
7Leukemia
07/2010 - 04/2005
5Breast Neoplasms (Breast Cancer)
01/2015 - 03/2002
3Carcinoma (Carcinomatosis)
06/2015 - 03/2002
3Sarcoma (Soft Tissue Sarcoma)
01/2012 - 04/2005
2Mesothelioma
09/2011 - 07/2008
1Retinal Degeneration
01/2015
1Inflammation
01/2015
1Brain Ischemia (Cerebral Ischemia)
01/2015
1Colorectal Neoplasms (Colorectal Cancer)
02/2013
1Neoplasm Metastasis (Metastasis)
02/2013
1Glioblastoma (Glioblastoma Multiforme)
01/2012
1Brain Neoplasms (Brain Tumor)
01/2012
1Glioma (Gliomas)
07/2008
1Microsatellite Instability
10/2005
1Astrocytoma (Pilocytic Astrocytoma)
04/2005

Drug/Important Bio-Agent (IBA)

34Telomerase (Telomerase Reverse Transcriptase)IBA
06/2015 - 01/2002
10DNA (Deoxyribonucleic Acid)IBA
01/2013 - 03/2002
3Messenger RNA (mRNA)IBA
10/2011 - 03/2002
3Telomere-Binding ProteinsIBA
06/2009 - 04/2005
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
06/2015 - 04/2008
2Small Interfering RNA (siRNA)IBA
01/2015 - 04/2014
2Glycoproteins (Glycoprotein)IBA
01/2015 - 02/2013
2Estrogens (Estrogen)FDA Link
04/2013 - 03/2002
2Histones (Histone)IBA
01/2012 - 08/2009
2ParaffinIBA
07/2010 - 01/2005
2Cyclin-Dependent Kinase Inhibitor p16IBA
08/2009 - 09/2002
2RibonucleoproteinsIBA
04/2009 - 03/2007
2telomerase RNA (bTR)IBA
07/2008 - 06/2008
2Proteins (Proteins, Gene)IBA
04/2005 - 10/2002
1RNA Splice SitesIBA
06/2015
1Biological Markers (Surrogate Marker)IBA
01/2015
1Transcription Factors (Transcription Factor)IBA
01/2015
1CyclinsIBA
07/2014
1Phosphotransferases (Kinase)IBA
07/2014
1Platelet-Derived Growth FactorIBA
02/2013
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
02/2013
1A-Form DNA (A-DNA)IBA
01/2013
17- O- (2,6- dideoxy- 2- fluorotalopyranosyl)daunomycinoneIBA
01/2012
13' Untranslated Regions (3' UTR)IBA
10/2011
1Ovarian epithelial cancerIBA
01/2011
1ProgesteroneFDA LinkGeneric
07/2009
1ChromatinIBA
06/2009
1decitabine (5-aza-2'-deoxycytidine)FDA Link
12/2007
1mortalinIBA
06/2006
1N-methylsuccinimideIBA
10/2005
1mirfentanilIBA
07/2005
1rhodacyanineIBA
08/2002
1MKT 077IBA
08/2002
1HormonesIBA
03/2002
1Estrogen Receptor Modulators (Antiestrogen)IBA
03/2002
1teleocalcinIBA
03/2002
1Carbon MonoxideIBA
01/2002

Therapy/Procedure

1Heterologous Transplantation (Xenotransplantation)
07/2014
1Hormone Replacement Therapy (Therapy, Hormone Replacement)
07/2009
1Aftercare (After-Treatment)
12/2007
1Drug Therapy (Chemotherapy)
03/2002
1Therapeutics
01/2002