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Nicos A Petasis Selected Research

chlorfenethol (DMC)

12/2012Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.
5/2011Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib.
3/2010Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature.
9/2009Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.
2/2008Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.
1/2008COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro.
4/2007Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
1/2006Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.
12/2005Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib.
5/2005Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

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Nicos A Petasis Research Topics

Disease

20Inflammation
02/2015 - 10/2002
18Neoplasms (Cancer)
04/2015 - 05/2005
6Peritonitis
08/2006 - 10/2002
3Breast Neoplasms (Breast Cancer)
12/2012 - 09/2009
3Glioma (Gliomas)
11/2012 - 03/2010
3Glioblastoma (Glioblastoma Multiforme)
12/2011 - 01/2008
2Pneumonia (Pneumonitis)
02/2015 - 11/2014
2Pain (Aches)
04/2012 - 02/2008
2Carcinoma (Carcinomatosis)
05/2011 - 01/2008
2Multiple Myeloma
06/2009 - 12/2005
2Cystic Fibrosis (Mucoviscidosis)
09/2005 - 04/2004
2Hypersensitivity (Allergy)
10/2002 - 06/2002
1Status Epilepticus (Complex Partial Status Epilepticus)
01/2015
1Lung Injury
10/2014
1Lymphedema (Milroy Disease)
01/2013
1Choroidal Neovascularization
01/2013
1Ovarian Neoplasms (Ovarian Cancer)
10/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
07/2012
1Stroke (Strokes)
07/2012
1Colorectal Neoplasms (Colorectal Cancer)
06/2012
1Colonic Neoplasms (Colon Cancer)
06/2012
1Neoplasm Metastasis (Metastasis)
06/2012
1Neuralgia (Stump Neuralgia)
04/2012
1Photosensitivity Disorders (Photodermatitis)
05/2011
1Alzheimer Disease (Alzheimer's Disease)
01/2011
1B-Cell Lymphoma (Lymphoma, B Cell)
02/2010
1Lymphoma (Lymphomas)
02/2010
1Sepsis (Septicemia)
10/2009
1Acute Lung Injury
08/2009

Drug/Important Bio-Agent (IBA)

13celecoxib (Celebrex)FDA Link
12/2012 - 05/2005
10chlorfenethol (DMC)IBA
12/2012 - 05/2005
9Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10/2014 - 06/2002
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2012 - 05/2005
6LipoxinsIBA
11/2009 - 06/2002
5neuroprotectin D1IBA
01/2015 - 02/2006
52,5-dimethylcelecoxibIBA
12/2012 - 04/2007
45S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acidIBA
08/2006 - 03/2005
3bortezomib (Velcade)FDA Link
04/2015 - 02/2008
37,14- dihydroxydocosa- 4,8,10,12,16,19- hexaenoic acidIBA
02/2015 - 04/2012
3Interleukin-8 (Interleukin 8)IBA
01/2013 - 03/2010
3Nelfinavir (Viracept)FDA Link
12/2012 - 09/2009
3Eicosapentaenoic AcidIBA
08/2006 - 03/2005
2epigallocatechin gallate (epigallocatechin-3-gallate)IBA
04/2015 - 06/2009
2TeaIBA
04/2015 - 06/2009
2Immunoglobulin G (IgG)IBA
10/2014 - 05/2005
2Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
02/2013 - 12/2008
2Chloroquine (Aralen)FDA LinkGeneric
12/2012 - 12/2012
2HIV ProteaseIBA
12/2012 - 09/2009
2temozolomide (Temodar)FDA LinkGeneric
11/2012 - 12/2011
2propiolic acidIBA
10/2012 - 04/2011
2AmidesIBA
10/2012 - 04/2011
2Proteins (Proteins, Gene)IBA
07/2012 - 04/2007
2Caspase 7IBA
06/2009 - 01/2008
2Small Interfering RNA (siRNA)IBA
02/2008 - 04/2007
2ZymosanIBA
08/2006 - 10/2005
2Polyisoprenyl PhosphatesIBA
10/2005 - 09/2005
2Interleukin-12 (IL 12)IBA
05/2005 - 03/2005
2EicosanoidsIBA
10/2002 - 06/2002
1Interleukin-13IBA
02/2015
1amphiregulin (schwannoma-derived growth factor)IBA
02/2015
1Interleukin-5 (Interleukin 5)IBA
02/2015
1Pilocarpine (Ocusert)FDA LinkGeneric
01/2015
1Antigen-Antibody Complex (Immune Complex)IBA
10/2014
1resolvin D1IBA
10/2014
1leukotriene A4 hydrolaseIBA
07/2013
1HormonesIBA
12/2012
1FluoroquinolonesIBA
12/2012
1quinolineIBA
12/2012
1Ofloxacin (Levofloxacin)FDA LinkGeneric
12/2012
1Mefloquine (Lariam)FDA LinkGeneric
12/2012
1Ciprofloxacin (Cipro)FDA LinkGeneric
12/2012
1perilla alcohol (perillyl alcohol)IBA
11/2012
1O(6)-Methylguanine-DNA MethyltransferaseIBA
11/2012
1Protein Disulfide-IsomerasesIBA
10/2012
1SodiumIBA
07/2012
1oxaliplatin (Eloxatin)FDA LinkGeneric
06/2012
12- hydroxy- N,N- dimethyl- 3- (2- ((1- (5- methylfuran- 2- yl)propyl)amino)- 3,4- dioxocyclobut- 1- enylamino)benzamideIBA
06/2012
1Interleukin-8A Receptors (Receptors, Interleukin 8A)IBA
06/2012
1Capsaicin (Zostrix)FDA Link
04/2012
1Noscapine (Narcotine)IBA
12/2011
11-phenyl-3,3-dimethyltriazene (PDT)IBA
05/2011
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2011
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2010
1Endothelin-1 (Endothelin 1)IBA
03/2010
1resolvin D2IBA
10/2009
1Drug CombinationsIBA
09/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2009
1trastuzumab (Herceptin)FDA Link
09/2009
1Paclitaxel (Taxol)FDA LinkGeneric
09/2009
1CarrageenanIBA
08/2009
1Oxidants (Oxidizing Agents)IBA
08/2009
1Peroxidase (Myeloperoxidase)IBA
08/2009

Therapy/Procedure

3Drug Therapy (Chemotherapy)
04/2012 - 01/2006
3Heterologous Transplantation (Xenotransplantation)
12/2011 - 03/2010
1Lasers (Laser)
01/2013
1Therapeutics
12/2012
1Intranasal Administration
11/2012
1Photochemotherapy (Photodynamic Therapy)
05/2011
1Ligation
10/2009
1Intraperitoneal Injections
08/2009