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John Pernow Selected Research

cyclo(Trp-Asp-Pro-Val-Leu)

1/2008Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy.
3/2007Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease.
3/2006Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance.
3/2002Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis.

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John Pernow Research Topics

Disease

16Ischemia
01/2014 - 06/2002
15Reperfusion Injury
01/2014 - 10/2002
10Atherosclerosis
11/2014 - 01/2002
10Myocardial Ischemia (Ischemic Heart Diseases)
01/2014 - 11/2002
9Coronary Artery Disease (Coronary Atherosclerosis)
11/2014 - 10/2004
7Cardiovascular Diseases (Cardiovascular Disease)
12/2014 - 08/2003
7Myocardial Infarction
11/2013 - 07/2002
5Diabetes Mellitus
02/2014 - 10/2012
5Type 2 Diabetes Mellitus (MODY)
09/2013 - 02/2005
5Insulin Resistance
08/2011 - 03/2006
3Hypertension (High Blood Pressure)
06/2013 - 02/2005
3Inflammation
09/2009 - 05/2003
2Anoxia (Hypoxia)
10/2014 - 05/2011
2Vascular Diseases (Vascular Disease)
09/2013 - 09/2010
2Heart Failure
06/2013 - 01/2013
1Heart Arrest (Cardiac Arrest)
10/2014
1Atherosclerotic Plaque (Atheroma)
03/2014
1Infection
03/2014
1Obesity
02/2014
1Overweight
02/2014
1Pulmonary Hypertension (Ayerza Syndrome)
06/2013
1Thrombosis (Thrombus)
04/2012
1Sinus Arrhythmia
02/2012
1Neoplasms (Cancer)
05/2011
1Heart Diseases (Heart Disease)
01/2010
1Pre-Eclampsia (Preeclampsia)
11/2009
1Albuminuria
01/2008
1Burns
08/2007
1Coronary Disease (Coronary Heart Disease)
02/2005
1Hypertriglyceridemia
05/2003

Drug/Important Bio-Agent (IBA)

12ArginaseIBA
10/2014 - 01/2010
10Endothelin-1 (Endothelin 1)IBA
11/2014 - 01/2002
10Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2014 - 10/2002
7Arginine (L-Arginine)FDA Link
01/2014 - 12/2003
5Endothelins (Endothelin)IBA
11/2014 - 05/2004
5Endothelin Receptors (Endothelin Receptor)IBA
11/2008 - 04/2002
4bosentan (Tracleer)FDA Link
09/2013 - 05/2004
4cyclo(Trp-Asp-Pro-Val-Leu)IBA
01/2008 - 03/2002
3C-Reactive ProteinIBA
02/2014 - 05/2003
3Nitric Oxide Synthase (NO Synthase)IBA
01/2014 - 05/2004
3omega-N-Methylarginine (NG Monomethyl L Arginine)IBA
01/2014 - 05/2004
3Insulin (Novolin)FDA Link
08/2009 - 03/2006
3Acetylcholine (Acetylcholine Chloride)FDA Link
03/2006 - 03/2002
2Simvastatin (Zocor)FDA LinkGeneric
12/2014 - 01/2009
2Carbon MonoxideIBA
03/2014 - 10/2013
2Lipoproteins (Lipoprotein)IBA
02/2014 - 08/2009
2erucylphosphocholineIBA
09/2013 - 09/2010
2Interleukin-6 (Interleukin 6)IBA
10/2012 - 05/2003
2tranilast (N 5')IBA
02/2012 - 01/2012
2Glucose (Dextrose)FDA LinkGeneric
08/2011 - 01/2009
2Biological Markers (Surrogate Marker)IBA
11/2009 - 05/2003
2AdiponectinIBA
08/2009 - 04/2008
2CholesterolIBA
07/2008 - 06/2007
2glucuronyl glucosamine glycan sulfate (Vessel)IBA
02/2007 - 06/2002
1Phosphatidylcholines (Phosphatidylcholine)IBA
12/2014
1AntigensIBA
03/2014
1Messenger RNA (mRNA)IBA
03/2014
1Peroxynitrous Acid (Peroxynitrite)IBA
01/2014
1hydroxyfasudilIBA
01/2014
15,6,7,8-tetrahydrobiopterin (tetrahydrobiopterin)FDA Link
10/2013
1InterleukinsIBA
10/2012
1Atenolol (Tenormin)FDA LinkGeneric
02/2012
1Metoprolol (Lopressor)FDA LinkGeneric
02/2012
1Neuropeptide YIBA
02/2012
1Tyrosine (L-Tyrosine)FDA Link
05/2011
1Tissue ExtractsIBA
05/2011
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
05/2011
1Cystatin CIBA
11/2009
1ezetimibe (Zetia)FDA Link
09/2009
1Protein Kinases (Protein Kinase)IBA
09/2009
1E-SelectinIBA
08/2009
1PPAR alphaIBA
03/2009
1Phosphotransferases (Kinase)IBA
03/2009
1Fibric Acids (Fibrates)IBA
03/2009
1LigandsIBA
03/2009
1Endothelin A ReceptorIBA
07/2008
1AMP-Activated Protein KinasesIBA
04/2008
1Idiopathic pulmonary hypertensionIBA
10/2007
1NF-kappa B (NF-kB)IBA
08/2007
1TNFR-Fc fusion protein (etanercept)FDA Link
08/2007
1salicylhydroxamic acid (SHAM)IBA
08/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2007
1Coenzyme A (CoA)IBA
06/2007
1Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA
06/2007
1Methanol (Carbinol)IBA
06/2007
1geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA
06/2007
1rosuvastatin (Crestor)FDA Link
06/2007
1OxidoreductasesIBA
06/2007
1PPAR gammaIBA
01/2007
1rosiglitazone (Avandia)FDA Link
01/2007
1Glucagon-Like Peptide 1 (GLP 1)IBA
02/2005
1mitochondrial K(ATP) channelIBA
02/2005
1von Willebrand FactorIBA
05/2003

Therapy/Procedure

4Intra-Arterial Infusions
01/2014 - 03/2002
2Ischemic Postconditioning
01/2013 - 04/2012
1Resuscitation
10/2014
1Stents
04/2012
1Intravenous Infusions
01/2012
1Organ Transplantation
05/2011
1Intraperitoneal Injections
06/2007