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John R Perfect Selected Research

Fluconazole (Zonal)

1/2015AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial.
6/2014Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study.
6/2013Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.
1/2012Cost-effectiveness of posaconazole versus fluconazole for prevention of invasive fungal infections in U.S. patients with graft-versus-host disease.
11/2011Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.
2/2010Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
12/2009Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update.
10/2007Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
2/2007Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.
9/2005Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.
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John R Perfect Research Topics

Disease

68Infection
09/2015 - 01/2002
15Aspergillosis
12/2009 - 03/2002
10Cryptococcosis
02/2014 - 05/2003
10Invasive Candidiasis
01/2012 - 05/2003
8Neutropenia
06/2014 - 11/2004
7Candidiasis (Moniliasis)
10/2009 - 05/2003
6Cryptococcal Meningitis
01/2015 - 01/2013
6Candidemia
03/2012 - 07/2003
5Hematologic Neoplasms (Hematological Malignancy)
04/2015 - 01/2007
5Neoplasms (Cancer)
01/2013 - 09/2006
4Meningoencephalitis
01/2014 - 02/2010
4Mycoses (Diseases, Fungus)
12/2009 - 01/2005
4Zygomycosis (Phycomycosis)
12/2009 - 11/2004
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/2014 - 03/2009
3Graft vs Host Disease (Graft-Versus-Host Disease)
01/2012 - 02/2007
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
06/2014 - 03/2009
2Mucormycosis
08/2012 - 03/2012
2Diabetes Mellitus
08/2012 - 10/2009
2Fungemia
02/2012 - 09/2005
2Communicable Diseases (Infectious Diseases)
01/2012 - 12/2004
2Critical Illness (Critically Ill)
06/2009 - 03/2009
2Osteomyelitis
03/2004 - 08/2003
1Endocarditis
09/2015
1Vitamin D Deficiency
08/2014
1Eosinophilia
02/2014
1Respiratory Tract Infections (Respiratory Tract Infection)
02/2014
1Acquired Immunodeficiency Syndrome (AIDS)
01/2014
1Central Nervous System Infections (Central Nervous System Infection)
11/2013
1Body Weight (Weight, Body)
06/2013
1Chronic Mucocutaneous Candidiasis
01/2013
1Inflammation
01/2013
1Tuberculosis (Tuberculoses)
01/2013
1Hepatic Insufficiency
01/2012
1Aneuploidy (Aneuploid)
11/2011
1Keratitis
09/2011
1Monosomy
01/2011

Drug/Important Bio-Agent (IBA)

14voriconazole (Vfend)FDA LinkGeneric
09/2011 - 03/2002
12Fluconazole (Zonal)FDA LinkGeneric
01/2015 - 11/2004
11Amphotericin B (Amphotericin)FDA LinkGeneric
09/2011 - 04/2002
9posaconazoleFDA Link
06/2014 - 03/2004
8liposomal amphotericin BFDA Link
01/2015 - 03/2004
7caspofungin (Cancidas)FDA Link
11/2006 - 04/2002
5CalcineurinIBA
09/2011 - 06/2003
4Antifungal AgentsIBA
03/2009 - 08/2003
3AntigensIBA
05/2015 - 01/2011
3Itraconazole (Sporanox)FDA LinkGeneric
06/2014 - 05/2003
3deoxycholate drug combination amphotericin BIBA
01/2014 - 11/2004
3polyhexamethylene biguanideIBA
09/2011 - 08/2003
3EchinocandinsIBA
12/2009 - 05/2006
2Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
02/2014 - 07/2012
2Biological Markers (Surrogate Marker)IBA
12/2013 - 01/2012
2Flucytosine (Ancobon)FDA Link
07/2013 - 02/2010
2galactomannanIBA
04/2013 - 07/2007
2deferasiroxFDA Link
08/2012 - 03/2012
2CytokinesIBA
02/2012 - 03/2007
2polyglucosanIBA
01/2012 - 11/2010
2anidulafunginFDA Link
01/2012 - 05/2006
2dectin 1IBA
10/2011 - 10/2009
2Cyclosporine (Ciclosporin)FDA LinkGeneric
09/2011 - 10/2007
2Glucose (Dextrose)FDA LinkGeneric
01/2011 - 08/2004
2micafungin (FK463)FDA Link
07/2010 - 05/2006
2Ergosterol (Lumisterol)IBA
01/2010 - 10/2007
1Immunosuppressive Agents (Immunosuppressants)IBA
04/2015
1Virulence Factors (Pathogenicity Factors)IBA
01/2015
125-hydroxyvitamin DIBA
08/2014
1hydroxide ionIBA
08/2014
1Interleukin-5 (Interleukin 5)IBA
02/2014
1RNA (Ribonucleic Acid)IBA
01/2014
1Systemic candidiasisIBA
12/2013
1NitrogenIBA
11/2013
1Interferon Type IIBA
01/2013
1Inositol (Myoinositol)IBA
01/2013
1Complement System Proteins (Complement)IBA
10/2012
1Immunologic Factors (Immunomodulators)IBA
07/2012
1Toll-Like Receptor 1IBA
03/2012
1IronIBA
03/2012
1Interleukin-10 (Interleukin 10)IBA
02/2012
1Interleukin-18 (Interleukin 18)IBA
02/2012
1Cytokine Receptors (Cytokine Receptor)IBA
02/2012
1Interleukin-8 (Interleukin 8)IBA
02/2012
1InterferonsIBA
02/2012
1Tacrolimus (Prograf)FDA LinkGeneric
09/2011
1DNA (Deoxyribonucleic Acid)IBA
08/2011
1PhosphoenolpyruvateIBA
01/2011
1Melanins (Melanin)IBA
01/2011
1Pyruvate KinaseIBA
01/2011
1Phosphotransferases (Kinase)IBA
01/2011

Therapy/Procedure

14Transplants (Transplant)
09/2015 - 01/2002
12Transplantation (Transplant Recipients)
09/2015 - 01/2002
6Drug Therapy (Chemotherapy)
09/2006 - 04/2002
3Salvage Therapy
09/2008 - 05/2003
2Catheters
08/2011 - 11/2003
2Organ Transplantation
01/2011 - 09/2006
2Lung Transplantation
11/2010 - 01/2002
2Hematopoietic Stem Cell Transplantation
06/2009 - 01/2007
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2007 - 07/2003
1Combination Drug Therapy (Combination Chemotherapy)
01/2013
1Chelation Therapy (Therapy, Chelation)
03/2012
1Total Parenteral Nutrition
02/2012
1Critical Care
01/2011