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Rifat Pamukcu Selected Research

sulindac sulfone (exisulind)

10/2003Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.
5/2003Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.
11/2002beta-Catenin signaling: therapeutic strategies in oncology.
11/2002Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.
11/2002Rapid development of colitis in NSAID-treated IL-10-deficient mice.
8/2002Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G.
4/2002CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
3/2002Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors.
2/2002Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer.

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Rifat Pamukcu Research Topics

Disease

5Neoplasms (Cancer)
05/2003 - 03/2002
4Colonic Neoplasms (Colon Cancer)
11/2002 - 01/2002
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2003 - 02/2002
2Lung Neoplasms (Lung Cancer)
03/2002 - 02/2002
1Prostatic Neoplasms (Prostate Cancer)
10/2003
1Inflammation
11/2002
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2002
1Colitis
11/2002
1Carcinoma (Carcinomatosis)
04/2002
1Glioblastoma (Glioblastoma Multiforme)
04/2002
1Gliosarcoma
04/2002
1Glioma (Gliomas)
04/2002
1Neoplasm Metastasis (Metastasis)
03/2002
1Colorectal Neoplasms (Colorectal Cancer)
02/2002
1Polyps
02/2002

Drug/Important Bio-Agent (IBA)

9sulindac sulfone (exisulind)IBA
10/2003 - 02/2002
4Cyclic GMPIBA
05/2003 - 03/2002
3docetaxel (Taxotere)FDA Link
05/2003 - 02/2002
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
10/2003 - 03/2002
2beta CateninIBA
11/2002 - 11/2002
2Sulindac (Copal)FDA LinkGeneric
11/2002 - 03/2002
2Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
11/2002 - 04/2002
2Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
11/2002 - 08/2002
1sulindac sulfideIBA
10/2003
1Androgen Receptors (Androgen Receptor)IBA
10/2003
1Protein Isoforms (Isoforms)IBA
05/2003
1Cyclin D1IBA
11/2002
1ProstaglandinsIBA
11/2002
1Interleukin-10 (Interleukin 10)IBA
11/2002
1Interferon-gamma (Interferon, gamma)IBA
11/2002
1diethylstilbestrol monophosphate (PDES)IBA
11/2002
1glycogen synthase kinase 3 betaIBA
11/2002
1taxaneIBA
03/2002
1EnzymesIBA
03/2002
1RNA (Ribonucleic Acid)IBA
01/2002
1Glutathione Transferase (Glutathione S-Transferase)IBA
01/2002
1Proteins (Proteins, Gene)IBA
01/2002

Therapy/Procedure

1Heterologous Transplantation (Xenotransplantation)
10/2003
1Aftercare (After-Treatment)
05/2003
1Chemoprevention
02/2002
1Drug Therapy (Chemotherapy)
02/2002