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Hisashi Oku Selected Research

pirfenidone

1/2012Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells.
8/2009[Pharmacological properties and clinical effects of the antifibrotic agent pirfenidone (Pirespa) for treatment of idiopathic pulmonary fibrosis].
8/2008Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
1/2008Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts.
6/2002Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock.
6/2002A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level.

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Hisashi Oku Research Topics

Disease

4Idiopathic Pulmonary Fibrosis
01/2012 - 01/2008
3Fibrosis (Cirrhosis)
01/2012 - 01/2008
2Pulmonary Fibrosis (Hamman Rich Syndrome)
01/2012 - 08/2008
2Shock
06/2002 - 06/2002
1Edema
08/2008
1Septic Shock (Toxic Shock Syndrome)
06/2002

Drug/Important Bio-Agent (IBA)

6pirfenidoneIBA
01/2012 - 06/2002
2CollagenIBA
01/2012 - 01/2008
2Bleomycin (Blenoxane)FDA LinkGeneric
01/2012 - 08/2008
2Collagen Type I (Type I Collagen)IBA
01/2012 - 01/2008
2CytokinesIBA
08/2008 - 06/2002
2Interleukin-10 (Interleukin 10)IBA
06/2002 - 06/2002
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2002 - 06/2002
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2008
1Transforming Growth Factor beta1 (TGF beta 1)IBA
08/2008
1Prednisolone (Predate)FDA LinkGeneric
08/2008
1indium-bleomycinIBA
08/2008
1GalactosamineIBA
06/2002
1Interferon-gamma (Interferon, gamma)IBA
06/2002
1Interleukin-6 (Interleukin 6)IBA
06/2002

Therapy/Procedure

1Oral Administration
06/2002