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Haruki Okamura Selected Research

Interleukin-18 (Interleukin 18)

1/2016Interleukin-18 disruption suppresses hypoxia-induced pulmonary artery hypertension in mice.
4/2013Zoledronic acid-induced expansion of γδ T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells.
1/2013Changes in interleukin 18 in the retinas of Otsuka long-evans Tokushima fatty rats, a model of human type 2 diabetes.
6/2012Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
6/2011Involvement of interleukin 18 in lens opacification of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes.
10/2010Increased interleukin-18 expression in nonrheumatic aortic valve stenosis.
1/2009Immunotherapy with interleukin-18 in combination with preoperative chemotherapy with ifosfamide effectively inhibits postoperative progression of pulmonary metastases in a mouse osteosarcoma model.
12/2008A role for IL-18 in human neutrophil apoptosis.
11/2008Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.
1/2008Enhanced suppression of pulmonary metastasis of malignant melanoma cells by combined administration of alpha-galactosylceramide and interleukin-18.
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Haruki Okamura Research Topics

Disease

20Neoplasms (Cancer)
11/2013 - 03/2002
9Osteosarcoma (Osteogenic Sarcoma)
04/2014 - 03/2004
6Mesothelioma
11/2013 - 12/2009
6Neoplasm Metastasis (Metastasis)
01/2009 - 03/2002
5Infection
01/2013 - 05/2002
4Inflammation
01/2015 - 12/2008
4Graft vs Host Disease (Graft-Versus-Host Disease)
04/2010 - 07/2002
3Hypertension (High Blood Pressure)
01/2016 - 04/2014
3Type 2 Diabetes Mellitus (MODY)
01/2013 - 05/2003
2Anoxia (Hypoxia)
01/2016 - 12/2012
2Stroke (Strokes)
09/2015 - 08/2014
2Fibrosis (Cirrhosis)
09/2013 - 10/2010
2Melanoma (Melanoma, Malignant)
09/2013 - 01/2008
2Multiple Myeloma
04/2013 - 11/2002
2Breast Neoplasms (Breast Cancer)
04/2013 - 03/2002
2Diabetes Mellitus
01/2013 - 06/2011
2Cataract (Cataracts)
06/2011 - 11/2007
2Lung Injury
10/2010 - 08/2005
2Pulmonary Fibrosis (Hamman Rich Syndrome)
10/2010 - 08/2005
2Interstitial Lung Diseases (Interstitial Lung Disease)
10/2010 - 08/2005
2Adenocarcinoma
09/2006 - 12/2004
2Colorectal Neoplasms (Colorectal Cancer)
09/2006 - 12/2004
2Myocardial Infarction
11/2005 - 05/2003
2Necrosis
11/2005 - 05/2002
2Wounds and Injuries (Trauma)
11/2004 - 03/2002
2Malaria
03/2003 - 05/2002
1Edema
01/2014
1Acute Liver Failure (Fulminant Hepatic Failure)
01/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2013
1Alcoholic Fatty Liver
09/2013
1Liver Cirrhosis (Hepatic Cirrhosis)
09/2013
1Renal Cell Carcinoma (Grawitz Tumor)
09/2013
1Lymphoma (Lymphomas)
05/2013
1Myeloid Leukemia (Leukemia, Myelocytic)
05/2013
1Carcinoma (Carcinomatosis)
05/2013
1Hyperglycemia
01/2013
1Acute Kidney Injury (Acute Renal Failure)
06/2012

Drug/Important Bio-Agent (IBA)

34Interleukin-18 (Interleukin 18)IBA
01/2016 - 02/2002
5Chymases (Chymase)IBA
08/2014 - 06/2012
5LigandsIBA
09/2013 - 11/2010
5Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
11/2012 - 07/2009
4zoledronic acid (zoledronate)FDA Link
05/2013 - 04/2010
4micaIBA
12/2012 - 12/2010
4Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2012 - 03/2002
4Histone Deacetylase InhibitorsIBA
11/2012 - 07/2009
4Messenger RNA (mRNA)IBA
11/2012 - 05/2002
4InterleukinsIBA
06/2012 - 11/2002
3TY 51469IBA
08/2014 - 06/2012
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2014 - 05/2002
3NitrogenIBA
05/2013 - 06/2012
3Interleukin-18 ReceptorsIBA
11/2008 - 07/2002
3CytokinesIBA
04/2007 - 03/2002
3Interleukin-12 (IL 12)IBA
02/2004 - 03/2002
2AngiotensinogenIBA
09/2015 - 04/2014
2Angiotensin Receptors (Angiotensin II Receptor)IBA
09/2015 - 04/2014
2midkineIBA
11/2013 - 08/2010
2Angiotensin IIIBA
09/2013 - 06/2012
2DiphosphonatesIBA
05/2013 - 12/2012
2Glucose (Dextrose)FDA LinkGeneric
01/2013 - 06/2011
2CholesterolIBA
01/2013 - 06/2011
2InterferonsIBA
01/2013 - 06/2011
2Proteins (Proteins, Gene)IBA
12/2012 - 08/2010
2NK Cell Lectin-Like Receptor Subfamily KIBA
12/2012 - 12/2010
2A-Form DNA (A-DNA)IBA
07/2012 - 11/2002
2Bleomycin (Blenoxane)FDA LinkGeneric
10/2010 - 08/2005
2Fas Ligand Protein (Fas Ligand)IBA
07/2009 - 03/2004
2Interferon-gamma (Interferon, gamma)IBA
11/2007 - 03/2003
2krestin (PSK)IBA
09/2006 - 12/2004
2Interleukin-6 (Interleukin 6)IBA
05/2003 - 03/2002
1beta 2-Glycoprotein I (Apolipoprotein H)IBA
09/2015
1GlucocorticoidsIBA
01/2015
1Norepinephrine (Noradrenaline)FDA LinkGeneric
04/2014
1EP4 Subtype Prostaglandin E ReceptorsIBA
04/2014
1GalactosamineIBA
01/2014
1ProgesteroneFDA LinkGeneric
01/2014
1Estrogens (Estrogen)FDA Link
01/2014
1adenovirus receptorIBA
11/2013
1Choline (Choline Chloride)IBA
09/2013
1Methionine (L-Methionine)FDA Link
09/2013
1Monoclonal AntibodiesIBA
09/2013
1GeranyltranstransferaseIBA
05/2013
1Retinaldehyde (Retinal)IBA
01/2013
1Small Interfering RNA (siRNA)IBA
12/2012
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
11/2012
1hydrazine (hydrazine dihydrochloride)IBA
07/2012
1Hydralazine (Apresoline)FDA LinkGeneric
07/2012
1AldosteroneIBA
06/2012
1Aldosterone ReceptorsIBA
06/2012
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
06/2012
1eplerenone (Inspra)FDA LinkGeneric
06/2012
1CreatinineIBA
06/2012
1AngiotensinsIBA
06/2012

Therapy/Procedure

7Immunotherapy
09/2013 - 09/2006
3Drug Therapy (Chemotherapy)
04/2013 - 01/2009
3Heterologous Transplantation (Xenotransplantation)
08/2010 - 12/2009
2Oncolytic Virotherapy
11/2013 - 08/2010
2Transplants (Transplant)
04/2010 - 11/2004
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
04/2010 - 07/2002
2Stem Cell Transplantation
11/2004 - 05/2004
1Transplantation (Transplant Recipients)
09/2013