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H Okamura Selected Research

Interleukin-18 (Interleukin 18)

3/2004Role of IL-18 in pathogenesis of endometriosis.
9/2002Increased circulating interleukin-18 in patients with congestive heart failure.
12/2001Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells.
11/2001Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
10/2001Interleukin-18 stimulates hematopoietic cytokine and growth factor formation and augments circulating granulocytes in mice.
8/2001Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection.
7/2001Fas ligand-induced caspase-1-dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease.
4/2001Interleukin-18 enhances the production of interleukin-8 by eosinophils.
3/2001Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu.
2/2001Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.
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H Okamura Research Topics

Disease

12Neoplasms (Cancer)
08/2011 - 01/2000
9Infection
12/2011 - 05/2000
8Inflammation
05/2006 - 01/2000
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2004 - 04/2001
3AIDS-Related Complex (ARC)
07/2010 - 01/2003
3Myocardial Infarction
06/2004 - 04/2001
3Endometriosis (Adenomyosis)
03/2004 - 01/2001
3Eosinophilia
04/2002 - 01/2000
3Asthma (Bronchial Asthma)
04/2002 - 01/2000
2Necrosis
01/2013 - 12/2000
2Mesothelioma
08/2011 - 08/2001
2Pain (Aches)
03/2004 - 02/2001
2Heart Failure
09/2002 - 04/2001
2Marek Disease (Marek's Disease)
11/2001 - 04/2000
2Graft vs Host Disease (Graft-Versus-Host Disease)
07/2001 - 06/2000
2Hypertension (High Blood Pressure)
03/2001 - 01/2000
2Pre-Eclampsia (Preeclampsia)
03/2001 - 07/2000
2Bacterial Infections (Bacterial Infection)
02/2001 - 06/2000
2Pulmonary Sarcoidosis
01/2001 - 11/2000
2Carcinoma (Carcinomatosis)
01/2001 - 01/2000
2Sarcoidosis (Schaumann Disease)
01/2001 - 11/2000
2Shock
07/2000 - 06/2000
2Neoplasm Metastasis (Metastasis)
05/2000 - 01/2000
1Hematemesis
05/2013
1Angina Pectoris
05/2013
1Stomach Neoplasms (Stomach Cancer)
05/2013
1Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive)
01/2013
1Stroke (Strokes)
05/2012
1Cytomegalovirus Infections (Inclusion Disease)
12/2011
1Endometrial Neoplasms (Endometrial Cancer)
07/2005
1Immune System Diseases (Immune Disorders)
03/2004
1Bronchogenic Cyst
09/2003
1Heart Arrest (Cardiac Arrest)
06/2002
1Bone Resorption
06/2002
1Pulmonary Eosinophilia (Eosinophilic Pneumonia)
04/2002
1Periodontitis
12/2001
1Abdominal Aortic Aneurysm
12/2001
1Vaginitis
09/2001

Drug/Important Bio-Agent (IBA)

24Interleukin-18 (Interleukin 18)IBA
03/2004 - 01/2000
10Interleukin-12 (IL 12)IBA
04/2002 - 01/2000
5CytokinesIBA
06/2002 - 01/2000
4AntigensIBA
12/2011 - 01/2000
4InterleukinsIBA
03/2004 - 06/2000
3Gonadotropin-Releasing Hormone (GnRH)FDA Link
07/2010 - 06/2001
3Fas Ligand Protein (Fas Ligand)IBA
02/2004 - 12/2000
2Okadaic AcidIBA
02/2004 - 12/2002
2VimentinIBA
09/2002 - 08/2001
2Immunoglobulin E (IgE)IBA
04/2002 - 01/2000
2Interleukin-4 (Interleukin 4)IBA
04/2002 - 04/2001
2AntibodiesIBA
11/2001 - 04/2000
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
03/2001 - 07/2000
2Interferon-gamma (Interferon, gamma)IBA
12/2000 - 06/2000
2Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2000 - 01/2000
1MonocrotalineIBA
01/2013
1TY 51469IBA
01/2013
1Chymases (Chymase)IBA
01/2013
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
05/2012
1Intravenous Immunoglobulins (IVIG)FDA Link
12/2011
1Immunoglobulins (Immunoglobulin)IBA
12/2011
1Cytosine DeaminaseIBA
08/2011
1Flucytosine (Ancobon)FDA Link
08/2011
1HormonesIBA
10/2009
1Telomerase (Telomerase Reverse Transcriptase)IBA
07/2005
1AutoantibodiesIBA
03/2004
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
03/2004
1NF-kappa B (NF-kB)IBA
02/2004
1CD95 Antigens (fas Receptor)IBA
02/2004
1Proteins (Proteins, Gene)IBA
02/2004
1Calcium Carbonate (Limestone)FDA Link
09/2003
1harpin (messenger)IBA
01/2003
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
12/2002
1von Willebrand FactorIBA
09/2002
1Neutralizing AntibodiesIBA
06/2002
1Interleukin-18 ReceptorsIBA
04/2002
1OvalbuminIBA
04/2002
1Interleukin-13IBA
04/2002
1proteinase InIBA
12/2001
1Toll-Like Receptors (Toll-Like Receptor)IBA
11/2001
1PerforinIBA
11/2001
1Interleukin-6 (Interleukin 6)IBA
10/2001
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
10/2001
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
10/2001
1Interleukin-5 (Interleukin 5)IBA
10/2001
1Estriol (Epiestriol)IBA
09/2001
1S100 Proteins (S 100 Protein)IBA
08/2001
1DesminIBA
08/2001
1Carcinoembryonic AntigenIBA
08/2001
1AsbestosIBA
08/2001

Therapy/Procedure

3Drug Therapy (Chemotherapy)
05/2013 - 05/2000
2Hysterectomy
09/2002 - 09/2000
2Ovariectomy (Oophorectomy)
09/2002 - 01/2001
2Transplants (Transplant)
12/2001 - 04/2001
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2001 - 06/2000
1Gastrectomy
05/2013
1Cell Transplantation
12/2011
1Heterologous Transplantation (Xenotransplantation)
08/2011
1Stents
05/2006
1Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump)
06/2004
1Angioplasty (Angioplasty, Transluminal)
08/2002
1Cardiopulmonary Bypass (Heart-Lung Bypass)
06/2002