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Ken Okamoto Selected Research

Xanthine Dehydrogenase

3/2015Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.
1/2015Evaluation of neuronal protective effects of xanthine oxidoreductase inhibitors on severe whole-brain ischemia in mouse model and analysis of xanthine oxidoreductase activity in the mouse brain.
1/2015The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
1/2012Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics.
6/2008Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.
4/2008[Inhibitors of xanthine oxidoreductase].

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Ken Okamoto Research Topics

Disease

18Neoplasms (Cancer)
01/2015 - 01/2004
7Stomach Neoplasms (Stomach Cancer)
01/2015 - 01/2005
6Hyperuricemia
03/2015 - 11/2004
5Gout
03/2015 - 04/2008
4Colorectal Neoplasms (Colorectal Cancer)
03/2015 - 01/2004
4Neoplasm Metastasis (Metastasis)
07/2012 - 07/2005
2Colonic Neoplasms (Colon Cancer)
03/2015 - 07/2012
2Brain Ischemia (Cerebral Ischemia)
01/2015 - 01/2015
2Inflammation
06/2012 - 09/2007
2Colic (Abdominal Cramps)
08/2007 - 01/2006
2Peptic Esophagitis (Reflux Esophagitis)
01/2007 - 01/2007
2Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
05/2006 - 01/2006
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2005 - 11/2004
2Sepsis (Septicemia)
05/2002 - 03/2002
1Psoriasis (Pustulosis Palmaris et Plantaris)
03/2015
1Skin Diseases
03/2015
1Reperfusion Injury
01/2015
1Diarrhea
06/2014
1Neuralgia (Stump Neuralgia)
03/2014
1Pain (Aches)
03/2014
1Fibromyalgia (Fibrositis)
03/2014
1Hyperalgesia
03/2014
1Fasciitis (Fascitis)
02/2014
1Disease Progression
11/2013
1Bone Resorption
03/2013
1Back Pain (Backache)
03/2013
1Heartburn (Pyrosis)
03/2013
1Postmenopausal Osteoporosis
03/2013
1Chronic Kidney Failure (Chronic Renal Failure)
07/2012
1Hemorrhage
07/2012
1Diabetes Mellitus
07/2012
1Intussusception
05/2012
1Adenocarcinoma
05/2012
1Aneurysm (Aneurysms)
10/2011
1Constipation
10/2011
1Renal Insufficiency (Renal Failure)
04/2008
1Hepatocellular Carcinoma (Hepatoma)
09/2007
1Renal Cell Carcinoma (Grawitz Tumor)
04/2007
1Thrombosis (Thrombus)
01/2007
1Anastomotic Leak
06/2006
1Pathologic Constriction (Stenosis)
06/2006
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/2006

Drug/Important Bio-Agent (IBA)

6Xanthine DehydrogenaseIBA
03/2015 - 04/2008
2TegafurIBA
01/2015 - 07/2012
2UracilIBA
01/2015 - 07/2012
2Uric Acid (Urate)IBA
01/2012 - 06/2008
2AmylasesFDA Link
01/2007 - 11/2004
2imatinib (Gleevec)FDA Link
05/2006 - 01/2006
2Thymidine PhosphorylaseIBA
06/2005 - 01/2004
2SodiumIBA
05/2002 - 03/2002
2Complement System Proteins (Complement)IBA
05/2002 - 03/2002
1Monoclonal AntibodiesIBA
03/2015
1panitumumab (Vectibix)FDA Link
03/2015
1cetuximab (Erbitux)FDA Link
03/2015
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
03/2015
14-hydroxy-2-nonenal (4-hydroxynonenal)IBA
01/2015
13-nitrotyrosineIBA
01/2015
1Fluorouracil (Carac)FDA LinkGeneric
06/2014
1TramadolFDA LinkGeneric
03/2014
1Reserpine (Serpasil)FDA Link
03/2014
1trastuzumab (Herceptin)FDA Link
11/2013
1collagen type I trimeric cross-linked peptideIBA
03/2013
1Collagen Type I (Type I Collagen)IBA
03/2013
1Alendronate (Alendronate Sodium)FDA LinkGeneric
03/2013
1Alkaline PhosphataseIBA
03/2013
1YM 529IBA
03/2013
1Leucovorin (Folinic Acid)FDA Link
07/2012
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
06/2012
1febuxostatFDA Link
01/2012
1purineIBA
01/2012
1OxygenIBA
01/2012
1Creatine Kinase (Creatine Phosphokinase)IBA
10/2011
1potassium oxonateIBA
01/2011
1FYX-051IBA
01/2011
1XanthineIBA
06/2008
1Allopurinol (Remid)FDA LinkGeneric
04/2008
1Indocyanine Green (Cardio-Green)FDA LinkGeneric
09/2007
1BariumIBA
06/2006
1Phosphotransferases (Kinase)IBA
05/2006
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
05/2006
1Tyrosine (L-Tyrosine)FDA Link
05/2006
1Paclitaxel (Taxol)FDA LinkGeneric
03/2006

Therapy/Procedure

8Gastrectomy
01/2015 - 01/2005
7Lymph Node Excision (Lymph Node Dissection)
05/2012 - 11/2004
3Oral Administration
01/2015 - 07/2012
3Ligation
03/2014 - 11/2004
3Drug Therapy (Chemotherapy)
11/2013 - 11/2005
3Pancreatectomy
09/2007 - 11/2004
2Aftercare (After-Treatment)
03/2013 - 01/2006
2Sutures (Suture)
01/2007 - 11/2004
1Adjuvant Chemotherapy
01/2015
1Decompression
10/2014
1Laparotomy
02/2014
1Laparoscopes (Laparoscope)
07/2012
1Renal Dialysis (Hemodialysis)
07/2012
1Colectomy
07/2012
1Enema (Enemas)
05/2012
1Hepatectomy
09/2007
1Cautery
08/2007
1Nephrectomy
04/2007