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John P Newnham Selected Research

Betamethasone (Celestone)

1/2022Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
1/2018The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy.
1/2018Extremely preterm fetal sheep lung responses to antenatal steroids and inflammation.
12/2013Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone.
1/2013Effects of intra-amniotic lipopolysaccharide and maternal betamethasone on brain inflammation in fetal sheep.
2/2012Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs.
1/2009Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.
7/2008Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny.
1/2008Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep.
7/2007Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs.
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John P Newnham Research Topics

Disease

41Inflammation (Inflammations)
01/2023 - 03/2002
32Chorioamnionitis
01/2023 - 07/2002
19Premature Birth (Birth, Premature)
06/2023 - 01/2002
17Pneumonia (Pneumonitis)
01/2018 - 03/2002
16Infections
01/2023 - 10/2010
10Body Weight (Weight, Body)
01/2019 - 01/2002
8Fetal Weight
01/2021 - 11/2003
6Birth Weight (Birth Weights)
01/2022 - 01/2002
5Premature Obstetric Labor (Premature Labor)
01/2022 - 09/2002
5Insulin Resistance
10/2017 - 10/2005
4Bronchopulmonary Dysplasia
03/2013 - 03/2002
4Fetal Growth Retardation (Intrauterine Growth Retardation)
08/2007 - 01/2002
3Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
11/2022 - 05/2009
3Ureaplasma Infections (Ureaplasma Infection)
01/2017 - 09/2010
3Lung Injury
12/2007 - 09/2002
2Brain Injuries (Brain Injury)
11/2020 - 01/2019
2Gestational Diabetes (Gestational Diabetes Mellitus)
10/2017 - 09/2014
2Pregnancy Complications
01/2016 - 09/2006
2Rupture
01/2016 - 08/2014
2Pain (Aches)
01/2013 - 06/2006
1Cardiovascular Diseases (Cardiovascular Disease)
11/2023
1Non-alcoholic Fatty Liver Disease
11/2022
1Perinatal Death
11/2022
1Hemorrhage
04/2022
1Methemoglobinemia
04/2022
1Anemia
04/2022
1Cholestasis
01/2021
1Intrahepatic Cholestasis of Pregnancy
01/2021
1Pruritus (Itching)
01/2021
1Hypotension (Low Blood Pressure)
11/2020
1Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)
01/2020
1Exotropia (Exophoria)
01/2020
1Hypertension (High Blood Pressure)
01/2020
1Esotropia (Esophoria)
01/2020
1Amblyopia (Lazy Eye)
01/2020
1Anisometropia
01/2020
1Cryptorchidism (Undescended Testes)
01/2018
1Hypospadias
01/2018
1Varicocele
01/2018
1Disease Progression
01/2018
1Bacteremia
10/2017

Drug/Important Bio-Agent (IBA)

25LipopolysaccharidesIBA
01/2023 - 08/2005
19Betamethasone (Celestone)FDA Link
01/2022 - 01/2002
16EndotoxinsIBA
03/2011 - 03/2002
14CytokinesIBA
06/2023 - 11/2005
11Adrenal Cortex Hormones (Corticosteroids)IBA
01/2022 - 01/2002
10GlucocorticoidsIBA
12/2013 - 09/2002
9Messenger RNA (mRNA)IBA
01/2017 - 04/2005
9Interleukin-1 (Interleukin 1)IBA
01/2016 - 03/2002
7Proteins (Proteins, Gene)FDA Link
09/2014 - 04/2005
6SteroidsIBA
11/2022 - 12/2016
5Anti-Bacterial Agents (Antibiotics)IBA
01/2021 - 10/2010
5Interleukin-8 (Interleukin 8)IBA
09/2014 - 11/2003
5Surface-Active Agents (Surfactants)IBA
05/2009 - 03/2002
4InterleukinsIBA
01/2021 - 05/2006
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2017 - 07/2003
3Bacterial DNAIBA
06/2023 - 01/2021
3ProgesteroneFDA LinkGeneric
07/2022 - 09/2002
3DNA (Deoxyribonucleic Acid)IBA
01/2021 - 04/2009
3Fluconazole (Zonal)FDA LinkGeneric
02/2016 - 06/2015
3solithromycinIBA
01/2016 - 01/2014
3MacrolidesIBA
01/2016 - 06/2011
3Interleukin-6 (Interleukin 6)IBA
09/2014 - 04/2009
3Erythromycin (Erycette)FDA LinkGeneric
08/2014 - 10/2010
2betamethasone sodium phosphateFDA LinkGeneric
01/2022 - 01/2018
2ChemokinesIBA
01/2017 - 06/2014
2Azithromycin (Zithromax)FDA LinkGeneric
09/2014 - 06/2011
2AntigensIBA
01/2012 - 09/2010
2Toll-Like Receptors (Toll-Like Receptor)IBA
01/2011 - 04/2009
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
05/2009 - 11/2005
2Budesonide (Pulmicort)FDA LinkGeneric
07/2007 - 11/2003
2Interleukin-1alpha (Interleukin 1 alpha)IBA
09/2006 - 03/2002
2ProstaglandinsIBA
09/2006 - 07/2002
2Saline SolutionIBA
11/2003 - 10/2002
1dimemorfan (AT 17)IBA
11/2022
1monobutyl phthalateIBA
11/2022
1APTIBA
04/2022
1Nitroglycerin (Dynamite)FDA LinkGeneric
04/2022
1Acetates (Acetic Acid Esters)FDA Link
01/2022
1betamethasone acetateFDA LinkGeneric
01/2022
1Ursodeoxycholic Acid (Urso)FDA LinkGeneric
01/2021
1Rifampin (Rifampicin)FDA LinkGeneric
01/2021
1TabletsIBA
01/2021
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
01/2021
1101.10 peptideIBA
01/2021
1dexamethasone 21-phosphateFDA LinkGeneric
11/2020
1Illicit Drugs (Recreational Drugs)IBA
01/2020
1phthalic acid (phthalate)IBA
01/2018
1Testosterone (Sustanon)FDA Link
01/2018
1betamethasone acetate phosphateFDA LinkGeneric
01/2018
1Diethylhexyl Phthalate (DEHP)IBA
01/2018
1AdipokinesIBA
10/2017

Therapy/Procedure

12Therapeutics
11/2023 - 01/2008
5Injections
07/2008 - 01/2002
3Aftercare (After-Treatment)
11/2022 - 10/2002
2Euthanasia (Mercy Killing)
04/2022 - 01/2019
2Intramuscular Injections
12/2003 - 12/2003
1Blood Transfusion (Blood Transfusions)
04/2022
1Catheters
01/2021
1Prenatal Care (Care, Prenatal)
12/2020