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Shinsaku Nakagawa Selected Research

Type I Tumor Necrosis Factor Receptors

2/2013Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy.
1/2011Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice.
1/2010[Creation of TNFR1-selective antagonist and its therapeutic effects].
12/2009The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.
10/2009Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.
8/2009Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists.
11/2008The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models.
1/2008Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.

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Shinsaku Nakagawa Research Topics

Disease

57Neoplasms (Cancer)
07/2015 - 03/2002
7Melanoma (Melanoma, Malignant)
12/2011 - 03/2002
6Inflammation
10/2013 - 05/2003
4Rheumatoid Arthritis
01/2010 - 01/2008
4Necrosis
08/2009 - 04/2002
3Neoplasm Metastasis (Metastasis)
07/2015 - 06/2011
3Autoimmune Diseases (Autoimmune Disease)
01/2010 - 08/2009
3Infection
01/2010 - 10/2008
3Carcinoma (Carcinomatosis)
11/2008 - 06/2005
2Tetanus
02/2012 - 01/2011
2Diphtheria
02/2012 - 01/2011
2Crohn Disease (Crohn's Disease)
01/2010 - 06/2008
2Communicable Diseases (Infectious Diseases)
01/2010 - 10/2008
2Hepatitis
11/2008 - 01/2008
2Fibrosarcoma
08/2008 - 03/2005
2Acute Kidney Injury (Acute Renal Failure)
03/2004 - 04/2003
1Lung Neoplasms (Lung Cancer)
07/2015
1Pain (Aches)
07/2015
1Human Influenza (Influenza)
07/2015
1Hypersensitivity (Allergy)
07/2014
1Meningoencephalitis
01/2014
1Alzheimer Disease (Alzheimer's Disease)
01/2014
1Seborrheic Keratosis
10/2013
1Hyperplasia
10/2013
1Malaria
06/2012
1Fetal Death
06/2011
1Multiple Sclerosis
01/2011
1Demyelinating Diseases (Demyelinating Disease)
01/2011
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2011
1Breast Neoplasms (Breast Cancer)
01/2011
1Rupture
09/2010
1Liver Neoplasms (Liver Cancer)
06/2010
1Disease Progression
04/2010

Drug/Important Bio-Agent (IBA)

20AntigensIBA
07/2015 - 04/2004
14Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2011 - 03/2002
8Proteins (Proteins, Gene)IBA
07/2015 - 06/2006
8Type I Tumor Necrosis Factor ReceptorsIBA
02/2013 - 01/2008
6ChemokinesIBA
01/2010 - 08/2003
5Interleukin-12 (IL 12)IBA
03/2010 - 01/2005
4VaccinesIBA
07/2015 - 03/2008
4Thymidine KinaseIBA
09/2011 - 07/2005
4Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
09/2011 - 09/2007
4PeptidesIBA
07/2009 - 01/2007
4arginyl-glycyl-aspartic acidIBA
02/2007 - 03/2002
3LuciferasesIBA
08/2012 - 01/2010
3HydrogelIBA
02/2012 - 10/2008
3OvalbuminIBA
06/2011 - 03/2008
3Type II Tumor Necrosis Factor ReceptorsIBA
01/2011 - 03/2009
3Liposomes (Liposome)IBA
03/2010 - 01/2006
3AntibodiesIBA
01/2010 - 07/2004
3poly(gamma-glutamic acid) (gamma-PGA)IBA
11/2008 - 02/2008
2Messenger RNA (mRNA)IBA
10/2013 - 06/2006
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
04/2013 - 03/2010
2CosmeticsIBA
08/2012 - 09/2010
2Neutralizing AntibodiesIBA
06/2012 - 06/2004
2Monophenol Monooxygenase (Tyrosinase)IBA
12/2011 - 07/2005
2Prostaglandins A (PGA)IBA
06/2011 - 01/2010
2Glutamic Acid (Glutamate)FDA Link
06/2011 - 01/2010
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2010 - 10/2007
2Chemokine CCL27IBA
02/2009 - 08/2003
2Carbon MonoxideIBA
11/2007 - 04/2004
2poly(vinylpyrrolidone-co-dimethyl maleic anhydride)IBA
05/2006 - 04/2003
2Drug CarriersIBA
05/2006 - 04/2004
2Integrin alphaVIBA
07/2005 - 04/2002
2InterleukinsIBA
01/2005 - 03/2002
2coxsackie-adenovirus receptorIBA
04/2002 - 03/2002
1Hemagglutinins (Hemagglutinin)IBA
07/2015
1Influenza Vaccines (FluMist)IBA
07/2015
1ProteomeIBA
07/2015
1oxysterol receptorIBA
07/2015
1ChromatinIBA
07/2014
1Deoxyribonucleases (DNase)IBA
07/2014
1Amyloid (Amyloid Fibrils)IBA
01/2014
1Tretinoin (Retinoic Acid)FDA LinkGeneric
10/2013
1Heparin (Liquaemin)FDA LinkGeneric
10/2013
1Epidermal Growth Factor (EGF)IBA
10/2013
1CollagenIBA
10/2013
1Lymphotoxin-alpha (Lymphotoxin)IBA
02/2013
1Immunoglobulin G (IgG)IBA
06/2012
1PolymersIBA
09/2011
1red fluorescent proteinIBA
06/2011
1Diphtheria Toxoid (Vaccine, Diphtheria)FDA Link
01/2011
1ToxoidsIBA
01/2011
1EphA1 Receptor (Eph Receptor)IBA
01/2011
1antineoplaston A10 (A 10)IBA
01/2011
1Keratin-8 (Keratin 8)IBA
01/2011
1Interleukin-1beta (Interleukin 1 beta)IBA
09/2010
1Silicon Dioxide (Sand)FDA LinkGeneric
09/2010
1Reactive Oxygen Species (Oxygen Radicals)IBA
09/2010
1ferumoxides (Feridex)FDA Link
06/2010
1ferric oxide (iron oxide)IBA
06/2010
1Biological Markers (Surrogate Marker)IBA
04/2010
1Lymphotoxin beta ReceptorIBA
04/2010
1Single-Chain AntibodiesIBA
03/2010
1CytokinesIBA
01/2010

Therapy/Procedure

14Immunotherapy
01/2010 - 04/2004
4Drug Therapy (Chemotherapy)
12/2004 - 03/2004
3Injections
07/2015 - 11/2007
3Therapeutics
07/2015 - 07/2009
1Subcutaneous Injections
07/2015