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Hideko Nagasawa Selected Research

2-nitroimidazole acetamide

10/2009Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
12/2008The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.
12/2006Design of hypoxia-targeting drugs as new cancer chemotherapeutics.
9/2005TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.
5/2002Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma.

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Hideko Nagasawa Research Topics

Disease

29Neoplasms (Cancer)
12/2015 - 05/2002
17Anoxia (Hypoxia)
02/2015 - 05/2002
4Inflammation
06/2008 - 11/2002
4Fever (Fevers)
02/2007 - 01/2003
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2006 - 01/2003
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2012 - 03/2004
3Breast Neoplasms (Breast Cancer)
07/2012 - 04/2012
3Neoplasm Metastasis (Metastasis)
10/2009 - 09/2005
2Hemorrhage
12/2015 - 01/2015
2Macular Degeneration (Age-Related Maculopathy)
12/2014 - 02/2011
1Endometriosis (Adenomyosis)
12/2015
1Iron Overload
12/2015
1Infertility (Sterility)
12/2015
1Disease Progression
08/2015
1Ovarian Neoplasms (Ovarian Cancer)
02/2015
1Choroidal Neovascularization
01/2015
1Stroke (Strokes)
01/2015
1Atrial Fibrillation
01/2015
1Hypoglycemia (Reactive Hypoglycemia)
01/2014
1Cardiovascular Diseases (Cardiovascular Disease)
09/2011
1Blindness (Hysterical Blindness)
02/2011
1Retinal Neovascularization
02/2011
1Diabetic Retinopathy (Retinopathy, Diabetic)
02/2011
1Retinopathy of Prematurity (Retrolental Fibroplasia)
02/2011
1Colonic Neoplasms (Colon Cancer)
10/2009
1Rectal Neoplasms (Rectal Cancer)
10/2009
1Peritonitis
06/2008
1Chronic Obstructive Pulmonary Disease (COPD)
11/2006
1Renal Cell Carcinoma (Grawitz Tumor)
03/2006
1Brain Neoplasms (Brain Tumor)
02/2006

Drug/Important Bio-Agent (IBA)

8Bromodeoxyuridine (BrdU)IBA
10/2010 - 01/2003
6tirapazamine (SR 4233)IBA
02/2015 - 01/2003
6Cytochalasin BIBA
03/2006 - 01/2003
53-amino-2-quinoxalinecarbonitrileIBA
02/2015 - 11/2003
52-nitroimidazole acetamideIBA
10/2009 - 05/2002
5SuspensionsIBA
03/2006 - 01/2003
4CytotoxinsIBA
12/2006 - 05/2002
4SASIBA
03/2006 - 01/2003
4vitamin D-binding protein-macrophage activating factorIBA
11/2005 - 05/2002
3LuciferasesIBA
08/2015 - 09/2011
3OxygenIBA
01/2015 - 05/2002
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2012 - 11/2003
3Fluorouracil (Carac)FDA LinkGeneric
07/2012 - 04/2012
3K 76 carboxylic acidIBA
07/2012 - 04/2012
3Propolis (Bee Bread)IBA
09/2011 - 07/2007
2Carbon MonoxideIBA
12/2015 - 08/2005
2IronIBA
12/2015 - 12/2014
2Angiogenesis InhibitorsIBA
02/2015 - 01/2011
2pimonidazoleIBA
01/2015 - 10/2010
22,4-thiazolidinedione (thiazolidinedione)IBA
01/2014 - 02/2011
2azomycinIBA
03/2012 - 05/2002
2BoronIBA
03/2011 - 12/2006
2artepillin CIBA
06/2008 - 07/2007
2N-acetylcochinol-O-phosphateIBA
01/2007 - 08/2005
2DNA (Deoxyribonucleic Acid)IBA
12/2006 - 06/2005
2Messenger RNA (mRNA)IBA
06/2006 - 06/2005
2TX 2100IBA
06/2006 - 02/2006
2Vitamin D-Binding ProteinIBA
11/2005 - 09/2004
2Cisplatin (Platino)FDA LinkGeneric
06/2005 - 01/2003
1Carrier Proteins (Binding Protein)IBA
12/2015
1Ovarian epithelial cancerIBA
12/2015
1AnticoagulantsIBA
01/2015
1Warfarin (Coumadin)FDA LinkGeneric
01/2015
1Triamcinolone Acetonide (Azmacort)FDA LinkGeneric
01/2015
1RhodaminesIBA
01/2015
1Antineoplastic Agents (Antineoplastics)IBA
01/2014
1alpha-Glucosidases (Acid Maltase)IBA
01/2014
1Glucose (Dextrose)FDA LinkGeneric
01/2014
1Phenformin (Fenformin)IBA
01/2014
1BiflavonoidsIBA
01/2013
12- (2- methoxy- 4- nitrophenyl)- 3- (4- nitrophenyl)- 5- (2,4- disulfophenyl)- 2H tetrazolium monosodium saltIBA
08/2012
13- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazoleIBA
04/2012
1FlavonoidsIBA
09/2011
1cyclic arginine-glycine-aspartic acid peptideIBA
03/2011
1arginyl-glycyl-aspartic acidIBA
03/2011
1Retinaldehyde (Retinal)IBA
02/2011
1ProdrugsIBA
01/2011
1Cytostatic AgentsIBA
01/2011
1mannosyl-oligosaccharide 1,3 - 1,6-alpha-mannosidaseIBA
03/2010
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
10/2009
1Plasminogen Activators (Plasminogen Activator)IBA
10/2009
1Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
09/2008
1NF-kappa B (NF-kB)IBA
06/2008
1CarrageenanIBA
06/2008
1TX-1898IBA
12/2006
1Proteins (Proteins, Gene)IBA
11/2006
1Hypoxia-Inducible Factor 1IBA
06/2006
1MisonidazoleIBA
03/2006
1NimorazoleIBA
03/2006
1Cadherins (E-Cadherin)IBA
03/2006
1mercaptoundecahydrododecaborate (borocaptate sodium)IBA
02/2006
1Actins (F Actin)IBA
11/2005
1Vitamin DFDA LinkGeneric
11/2005

Therapy/Procedure

7Heterologous Transplantation (Xenotransplantation)
07/2012 - 06/2005
5Boron Neutron Capture Therapy
03/2011 - 09/2004
2Drug Therapy (Chemotherapy)
07/2012 - 03/2010
1Lasers (Laser)
01/2015
1Aftercare (After-Treatment)
03/2012
1Therapeutics
12/2006
1Radiotherapy
03/2006