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Taku Nagai Selected Research

spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- one

2/2007A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.

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Taku Nagai Research Topics

Disease

15Schizophrenia (Dementia Praecox)
05/2014 - 02/2007
6Alzheimer Disease (Alzheimer's Disease)
08/2015 - 07/2005
4Substance-Related Disorders (Drug Abuse)
07/2007 - 01/2004
3Rheumatoid Arthritis
01/2012 - 09/2005
2Infection
05/2014 - 01/2014
2Neurodegenerative Diseases (Neurodegenerative Disease)
08/2013 - 02/2004
2Memory Disorders (Memory Loss)
08/2013 - 02/2013
2Neoplasms (Cancer)
07/2012 - 10/2009
2T-Cell Lymphoma (Lymphoma, T Cell)
01/2012 - 06/2011
2Mental Disorders (Mental Disorder)
11/2011 - 04/2010
2Synovitis
10/2006 - 09/2005
1Amyloid Plaque
08/2015
1Gambling (Pathological Gambling)
07/2015
1Frontotemporal Lobar Degeneration (Semantic Dementia)
01/2015
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2015
1Fibrosis (Cirrhosis)
09/2014
1Major Depressive Disorder (Major Depressive Disorders)
05/2014
1Stomach Neoplasms (Stomach Cancer)
04/2014
1Ischemia
04/2014
1Seizures (Seizure)
01/2013
1Atherosclerosis
08/2012
1Neoplasm Metastasis (Metastasis)
07/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
07/2012
1Arthritis (Polyarthritis)
01/2012
1Epstein-Barr Virus Infections
06/2011
1B-Cell Lymphoma (Lymphoma, B Cell)
06/2011
1Lymphoma (Lymphomas)
06/2011
1Necrosis
06/2011
1Genetic Predisposition to Disease (Genetic Predisposition)
01/2011
1Anoxia (Hypoxia)
05/2010
1Hallucinations (Hallucination)
04/2010
1Paranoid Schizophrenia (Delusional Disorder)
04/2010
1Glioma (Gliomas)
10/2009
1Glioblastoma (Glioblastoma Multiforme)
10/2009
1Tobacco Use Disorder (Nicotine Dependence)
06/2008
1Pressure Ulcer (Bedsore)
03/2008

Drug/Important Bio-Agent (IBA)

6Immunotoxins (Immunotoxin)IBA
09/2014 - 09/2005
5Methamphetamine (Desoxyn)FDA LinkGeneric
07/2015 - 03/2004
4Antipsychotic Agents (Antipsychotics)IBA
05/2014 - 04/2010
4Folate Receptor 2IBA
01/2012 - 09/2005
3Messenger RNA (mRNA)IBA
01/2015 - 07/2009
3Folic Acid (Vitamin M)FDA LinkGeneric
09/2014 - 07/2012
3AntigensIBA
01/2012 - 03/2008
3Phencyclidine (Angel Dust)IBA
08/2010 - 03/2007
2N-Methylaspartate (NMDA)IBA
08/2015 - 08/2010
2nobiletinIBA
08/2015 - 08/2013
2RNA (Ribonucleic Acid)IBA
01/2015 - 05/2010
2Antidepressive Agents (Antidepressants)IBA
05/2014 - 02/2004
2tebufenozide (Mimic)IBA
05/2014 - 01/2014
2Dehydroepiandrosterone SulfateIBA
05/2014 - 07/2004
2GABA-B Receptors (Receptor, GABA-B)IBA
01/2009 - 12/2008
2ExotoxinsIBA
10/2006 - 09/2005
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2005 - 03/2004
1flavoneIBA
08/2015
1Amyloid (Amyloid Fibrils)IBA
08/2015
1DNA-Binding Proteins (DNA Binding Protein)IBA
01/2015
1AMPA Receptors (AMPA Receptor)IBA
01/2015
1Bleomycin (Blenoxane)FDA LinkGeneric
09/2014
1Hydroxyproline (4 Hydroxyproline)IBA
09/2014
1Histones (Histone)IBA
05/2014
1Dehydroepiandrosterone (DHEA)IBA
05/2014
1Fluorouracil (Carac)FDA LinkGeneric
04/2014
1Biological Markers (Surrogate Marker)IBA
04/2014
1HydrogenIBA
04/2014
1Cisplatin (Platino)FDA LinkGeneric
04/2014
11-bromopropane (propyl bromide)IBA
02/2013
1Pentylenetetrazole (Metrazol)IBA
01/2013
1ApolipoproteinsIBA
08/2012
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2012
1methylated bovine serum albumin (MBSA)IBA
01/2012
1Freund's AdjuvantIBA
01/2012
1Caspase 3 (Caspase-3)IBA
01/2012
1rivastigmine (Exelon)FDA LinkGeneric
11/2011
1Clozapine (Clozaril)FDA LinkGeneric
11/2011
1Cholinesterases (Cholinesterase)IBA
11/2011
1EnzymesIBA
06/2011
1Cathepsin DIBA
06/2011
1Neuregulin-1 (Neuregulin 1)IBA
01/2011
1HMGA1a ProteinIBA
05/2010
1DNA (Deoxyribonucleic Acid)IBA
05/2010
1Trans-Activators (Trans-Acting Factor)IBA
05/2010
1Presenilin-2IBA
05/2010
1RNA Precursors (Precursor, mRNA)IBA
05/2010
1dystrobrevinIBA
02/2010
1Amyloid beta-PeptidesIBA
11/2009
1aripiprazole (Abilify)FDA Link
01/2009
1NicotineFDA Link
06/2008
1Tryptases (Tryptase)IBA
03/2008
1Chymases (Chymase)IBA
03/2008
1Monoclonal AntibodiesIBA
03/2008
1Serotonin (5 Hydroxytryptamine)IBA
03/2008
1Proteins (Proteins, Gene)IBA
07/2007
1Levodopa (L Dopa)FDA LinkGeneric
03/2007
1Dizocilpine Maleate (Dizocilpine)IBA
03/2007

Therapy/Procedure

3Drug Therapy (Chemotherapy)
04/2014 - 03/2007
1Therapeutics
05/2013
1Subcutaneous Injections
01/2012
1Intra-Articular Injections
01/2012
1Heterologous Transplantation (Xenotransplantation)
10/2009
1Self Administration (Administration, Self)
07/2007