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Robert Naeije Selected Research

bosentan (Tracleer)

9/2010Pulmonary vasoreactivity predicts long-term outcome in patients with Eisenmenger syndrome receiving bosentan therapy.
5/2010Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies.
5/2009Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia.
5/2007Does endothelin play a role in chemoreception during acute hypoxia in normal men?
5/2006Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan.
1/2006Role of endothelins and nitric oxide in the pulmonary circulation of perinatal lambs during hyperoxia and hypoxia.
6/2003Endothelin receptor blockade in canine oleic acid-induced lung injury.
3/2003Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension.

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Robert Naeije Research Topics

Disease

39Pulmonary Hypertension (Ayerza Syndrome)
04/2015 - 03/2002
23Anoxia (Hypoxia)
01/2014 - 07/2002
13Heart Failure
01/2016 - 12/2003
6Hypertension (High Blood Pressure)
01/2014 - 03/2003
5Dyspnea (Shortness of Breath)
01/2014 - 03/2002
5Lung Injury
07/2010 - 04/2002
5Hyperoxia
11/2008 - 08/2004
4Heart Diseases (Heart Disease)
08/2014 - 05/2006
4Connective Tissue Diseases (Connective Tissue Disease)
09/2012 - 03/2002
4Pulmonary Edema
08/2009 - 05/2003
4Pain (Aches)
01/2008 - 03/2002
3Vascular Diseases (Vascular Disease)
03/2015 - 08/2005
3Eisenmenger Complex (Eisenmenger's Syndrome)
09/2013 - 09/2010
3Myocardial Infarction
01/2010 - 01/2009
3Hypercapnia
11/2008 - 09/2003
2Inflammation
10/2015 - 01/2013
2Hyperplasia
03/2015 - 11/2006
2Polycythemia (Erythrocytosis)
04/2014 - 06/2013
2Altitude Sickness (Mountain Sickness)
06/2013 - 10/2006
2Fibrosis (Cirrhosis)
09/2012 - 12/2011
2Acute Lung Injury
07/2010 - 04/2002
2Ischemia
11/2009 - 11/2008
2Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve)
04/2009 - 10/2005
2Hypertrophy
01/2009 - 10/2008
2Tachycardia (Tachyarrhythmias)
10/2008 - 12/2003
2Apnea
05/2007 - 09/2003
2Syncope (Fainting)
08/2002 - 03/2002
1Body Weight (Weight, Body)
04/2015
1Hypotension (Low Blood Pressure)
03/2015
1Chronic Disease (Chronic Diseases)
03/2015
1Disease Progression
03/2015
1Lung Diseases (Lung Disease)
08/2014
1Ventricular Fibrillation
05/2014
1Cardiovascular Diseases (Cardiovascular Disease)
05/2014
1Edema
07/2013
1Systolic Heart Failure
03/2013
1Hypoventilation
10/2012
1Pulmonary Fibrosis (Hamman Rich Syndrome)
09/2012
1Necrosis
04/2012
1Hyperventilation
01/2011
1Sickle Cell Anemia (Hemoglobin S Disease)
05/2010

Drug/Important Bio-Agent (IBA)

23Idiopathic pulmonary hypertensionIBA
01/2016 - 03/2002
15OxygenIBA
08/2014 - 06/2004
8Epoprostenol (Prostacyclin)FDA LinkGeneric
10/2015 - 08/2002
8bosentan (Tracleer)FDA Link
09/2010 - 03/2003
6Endothelins (Endothelin)IBA
03/2015 - 06/2003
5Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2006 - 03/2003
4sildenafil (Viagra)FDA Link
04/2012 - 10/2004
4treprostinilFDA Link
01/2008 - 03/2002
3Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
03/2015 - 12/2011
3Endothelin Receptors (Endothelin Receptor)IBA
03/2015 - 06/2003
3Clostridium perfringens epsilon-toxinIBA
08/2014 - 01/2011
3glucuronyl glucosamine glycan sulfate (Vessel)IBA
01/2014 - 01/2004
3Dexamethasone (Maxidex)FDA LinkGeneric
08/2009 - 03/2005
3tadalafil (Cialis)FDA Link
08/2009 - 03/2005
3Lactic AcidFDA LinkGeneric
07/2006 - 04/2005
3DobutamineFDA LinkGeneric
10/2005 - 04/2003
3Oleic Acid (Oleate)IBA
06/2003 - 04/2002
2Endothelin-1 (Endothelin 1)IBA
01/2014 - 03/2003
2Vasodilator Agents (Vasodilators)IBA
07/2013 - 11/2003
2Bisoprolol (Concor)FDA LinkGeneric
07/2013 - 11/2008
2Serotonin (5 Hydroxytryptamine)IBA
07/2010 - 05/2010
2Transforming Growth Factor beta (TGF-beta)IBA
01/2009 - 10/2008
2sitaxsentanIBA
03/2007 - 05/2006
2SodiumIBA
07/2006 - 05/2003
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
07/2006 - 08/2004
2Angiotensin IIIBA
10/2004 - 08/2004
1Congenital diaphragmatic herniaIBA
04/2015
1nitrofen (TOK)IBA
04/2015
1Simvastatin (Zocor)FDA LinkGeneric
04/2015
1Carbon MonoxideIBA
03/2015
1ProstaglandinsIBA
03/2015
115-phenyl-beta-methylpentadecanoic acidIBA
10/2014
1lysophosphatidic acid (MOPA)IBA
09/2014
1Uric Acid (Urate)IBA
05/2014
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2014
1Interleukin-6 (Interleukin 6)IBA
01/2014
1LeptinIBA
01/2014
14-S-(propionic acid)sulfidocyclophosphamide (PASP)IBA
10/2013
1Atropine (Hyoscyamine)FDA LinkGeneric
07/2013
1Acetazolamide (Diamox)FDA LinkGeneric
06/2013
1Heme Oxygenase-1IBA
01/2013
1Chloride Channels (Chloride Channel)IBA
09/2012
1MelatoninIBA
09/2012
1Protein Kinase CIBA
09/2012
15-nitro-2-(3-phenylpropylamino)benzoic acidIBA
04/2012
1N-propionylprocainamideIBA
04/2012
1CytokinesIBA
04/2012
1InterleukinsIBA
04/2012
1IronIBA
11/2011
1vasectrin IIIIBA
09/2011
1Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
05/2010
1Digoxin (Digitek)FDA LinkGeneric
11/2009

Therapy/Procedure

3Catheters
12/2013 - 03/2002
3Transplantation (Transplant Recipients)
09/2013 - 01/2006
3Endarterectomy (Thromboendarterectomy)
04/2013 - 01/2004
1Transplants (Transplant)
03/2015
1Heart Transplantation (Grafting, Heart)
05/2014
1Lung Transplantation
09/2010
1Ligation
01/2010