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Shigeki Moriguchi Selected Research

spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- one

7/2008Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus.

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Shigeki Moriguchi Research Topics

Disease

7Ischemia
10/2009 - 09/2005
5Alzheimer Disease (Alzheimer's Disease)
03/2014 - 10/2005
5Brain Ischemia (Cerebral Ischemia)
10/2009 - 09/2005
3Embolism (Embolus)
01/2008 - 09/2005
2Learning Disorders (Learning Disability)
02/2012 - 04/2006
2Memory Disorders (Memory Loss)
10/2009 - 07/2008
2Hypertrophy
01/2009 - 12/2007
2Myocardial Ischemia (Ischemic Heart Diseases)
01/2008 - 10/2007
2Dementia (Dementias)
12/2003 - 10/2003
1Autistic Disorder (Autism)
01/2014
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2013
1X-Linked Mental Retardation (Mental Retardation, X Linked)
06/2011
1Thalassemia
06/2011
1Bipolar Disorder (Mania)
01/2009
1Schizophrenia (Dementia Praecox)
01/2009
1Myocardial Infarction
01/2008
1Reperfusion Injury
10/2007
1Rhabdomyosarcoma
09/2007
1Mood Disorders (Mood Disorder)
09/2006
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
07/2006
1Intracranial Embolism
09/2005
1Stroke (Strokes)
10/2003

Drug/Important Bio-Agent (IBA)

6Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2014 - 04/2006
3Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2008 - 09/2006
3Tyrosine (L-Tyrosine)FDA Link
01/2008 - 09/2005
3CalcineurinIBA
12/2007 - 07/2006
33- (2- (4- (3- chloro- 2- methylphenyl)1- piperazinyl)ethyl)5,6- dimethoxy- 1- (4- imidazolylmethyl)- 1H- indazol dihydrochloride 3.5 hydrateIBA
12/2007 - 09/2005
3N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
02/2007 - 12/2003
23- (2- (4- (3- chloro- 2- methylphenyl)- 1- piperazinyl)ethyl)- 5,6- dimethoxyindazoleIBA
01/2009 - 12/2007
2Fas Ligand Protein (Fas Ligand)IBA
10/2007 - 09/2007
2CalpainIBA
09/2007 - 07/2006
2N-Methylaspartate (NMDA)IBA
02/2007 - 10/2005
2Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
02/2007 - 10/2005
2nefiracetamIBA
12/2003 - 10/2003
1rivastigmine (Exelon)FDA LinkGeneric
03/2014
1MelatoninIBA
01/2014
1Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2014
1Piracetam (Nootropil)IBA
10/2013
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
02/2012
1ATR-X syndromeIBA
06/2011
1Adenosine Triphosphate (ATP)IBA
06/2011
1nobiletinIBA
10/2009
1Nerve Growth Factors (Neurotrophins)IBA
01/2009
1CytokinesIBA
01/2009
1indanIBA
07/2008
1spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- oneIBA
07/2008
1pyridineIBA
07/2008
1Glutamic Acid (Glutamate)FDA Link
01/2008
1CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
01/2008
1vanadyl sulfateIBA
01/2008
1DystrophinIBA
12/2007
1Phenylephrine (Neo-Synephrine)FDA LinkGeneric
12/2007
1phospholambanIBA
12/2007
1Endothelin-1 (Endothelin 1)IBA
12/2007
1Angiotensin IIIBA
12/2007
1Tacrolimus (Prograf)FDA LinkGeneric
09/2007
1Transcription Factors (Transcription Factor)IBA
09/2007
1LithiumIBA
09/2006
1Calcium-Calmodulin-Dependent Protein KinasesIBA
09/2006
1Cholinesterases (Cholinesterase)IBA
10/2005
1donepezil (Aricept)FDA LinkGeneric
10/2005
1Calmodulin (Calcium-Dependent Activator Protein)IBA
09/2005
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
09/2005
1Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2005

Therapy/Procedure

3Microspheres (Microsphere)
01/2008 - 09/2005
1Therapeutics
04/2011
1Oral Administration
07/2008