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Jean-Louis Montero Selected Research

Carbonic Anhydrase Inhibitors

9/2009Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.
11/2008Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.
1/2008Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
1/2008Design of zinc binding functions for carbonic anhydrase inhibitors.
9/2007Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
9/2006Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
8/2006New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.
5/2005Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
5/2005Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
2/2005Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
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Jean-Louis Montero Research Topics

Disease

28Neoplasms (Cancer)
06/2013 - 05/2003
4Anoxia (Hypoxia)
05/2008 - 07/2005
3Glaucoma
01/2007 - 01/2004
2Infection
05/2011 - 03/2005
2Obesity
01/2008 - 03/2005
2Atherosclerosis
06/2006 - 03/2005
1Seizures (Seizure)
05/2007
1Pathologic Processes
08/2006
1Stroke (Strokes)
06/2006
1Myocardial Infarction
06/2006
1Cicatrix (Scar)
05/2006
1Weight Loss (Weight Reduction)
03/2005
1Hyperlipidemias (Hyperlipidemia)
03/2005
1Prostatic Neoplasms (Prostate Cancer)
03/2005
1Breast Neoplasms (Breast Cancer)
03/2005
1Renal Cell Carcinoma (Grawitz Tumor)
11/2004
1Melanoma (Melanoma, Malignant)
11/2003
1Carcinoma (Carcinomatosis)
10/2003
1Leukemia
12/2002

Drug/Important Bio-Agent (IBA)

21Carbonic Anhydrases (Carbonic Anhydrase)IBA
05/2011 - 05/2003
13Carbonic Anhydrase InhibitorsIBA
09/2009 - 12/2003
13IsoenzymesIBA
09/2009 - 05/2003
12SulfonamidesIBA
05/2011 - 01/2004
9Protein Isoforms (Isoforms)IBA
06/2013 - 09/2006
6ZincIBA
01/2007 - 05/2003
2BoronIBA
05/2011 - 07/2005
2CopperIBA
11/2008 - 01/2008
2Carbon DioxideIBA
05/2008 - 08/2006
2topiramate (Topamax)FDA LinkGeneric
05/2007 - 03/2005
2Anti-Obesity Agents (Antiobesity Drugs)IBA
01/2007 - 08/2006
2EnzymesIBA
08/2006 - 05/2006
2NSC 224131 (PALA)IBA
03/2005 - 10/2003
2sulfamic acid (ammonium sulfamate)IBA
03/2005 - 12/2003
2SulfatasesIBA
03/2005 - 05/2003
1KetonesIBA
05/2011
1boroxazolidoneIBA
05/2011
1PhenolsIBA
09/2009
1Boronic AcidsIBA
05/2009
1diphenyl (biphenyl)IBA
05/2009
1Pentetic Acid (DTPA)FDA LinkGeneric
11/2008
1Protons (Proton)IBA
05/2008
1Transcription Factors (Transcription Factor)IBA
05/2008
1Sulfhydryl Compounds (Thiols)IBA
09/2006
1HydrogenIBA
09/2006
1NitrogenIBA
09/2006
1Anti-Ulcer AgentsIBA
08/2006
1Bicarbonates (Hydrogen Carbonate)IBA
08/2006
1DiureticsIBA
08/2006
1Arachidonic Acid (Vitamin F)IBA
06/2006
1Mannose (D-Mannose)IBA
05/2006
1IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA
05/2006
1Transforming Growth Factor beta (TGF-beta)IBA
05/2006
1Proteins (Proteins, Gene)IBA
03/2005
1avasimibeIBA
03/2005
1Anti-Bacterial Agents (Antibiotics)IBA
03/2005
1LigasesIBA
03/2005
1Transfer RNA (tRNA)IBA
03/2005
1HormonesIBA
03/2005
11,2,4-triazineIBA
11/2004
1dorzolamide (Trusopt)FDA LinkGeneric
01/2004
1brinzolamide (Azopt)FDA Link
01/2004
1O-(6)-methylguanineIBA
11/2003
1DNA (Deoxyribonucleic Acid)IBA
11/2003
1O(6)-benzylguanineIBA
11/2003
1Complementary DNA (cDNA)IBA
11/2003
1fotemustine (Muphoran)IBA
11/2003
1ProdrugsIBA
10/2003
1Steryl-Sulfatase (Steroid Sulfatase)IBA
05/2003
1Estrogens (Estrogen)FDA Link
05/2003
1Dehydroepiandrosterone (DHEA)IBA
05/2003
1estrone sulfataseIBA
05/2003
1bexarotene (LGD1069)FDA Link
12/2002

Therapy/Procedure

4Drug Therapy (Chemotherapy)
07/2009 - 05/2003
2Boron Neutron Capture Therapy
05/2011 - 07/2005
2Radiotherapy
05/2008 - 07/2005