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Jürgen Moll Selected Research

aurora kinase (aurora A kinase)

9/2012Targeting aurora kinases with danusertib (PHA-739358) inhibits growth of liver metastases from gastroenteropancreatic neuroendocrine tumors in an orthotopic xenograft model.
1/2012Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib).
7/2009Is there a future for Aurora kinase inhibitors for anticancer therapy?
12/2008PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases.
1/2008Target validation and biomarker identification in oncology : the example of aurora kinases.
1/2008Aurora kinase inhibitors: identification and preclinical validation of their biomarkers.
12/2007PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.
9/2007Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.

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Jürgen Moll Research Topics

Disease

12Neoplasms (Cancer)
01/2013 - 07/2006
4BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2011 - 09/2007
3Leukemia
01/2012 - 04/2008
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
03/2015 - 04/2012
2Aneuploidy (Aneuploid)
09/2012 - 10/2010
2Hematologic Neoplasms (Hematological Malignancy)
04/2012 - 09/2007
2Blast Crisis (Blast Phase)
12/2008 - 04/2008
1Multiple Myeloma
01/2013
1Neuroendocrine Tumors (Neuroendocrine Tumor)
09/2012
1Neoplasm Metastasis (Metastasis)
09/2012
1Adenocarcinoma
04/2012
1Philadelphia Chromosome
01/2012
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2012
1Breast Neoplasms (Breast Cancer)
07/2006
1Shock
01/2004

Drug/Important Bio-Agent (IBA)

8aurora kinase (aurora A kinase)IBA
09/2012 - 09/2007
7Phosphotransferases (Kinase)IBA
03/2015 - 09/2007
4PHA 739358IBA
01/2012 - 09/2007
4imatinib (Gleevec)FDA Link
01/2011 - 09/2007
2Bcr-Abl tyrosine kinaseIBA
01/2012 - 12/2008
1PHA 767491IBA
01/2013
1Melphalan (Alkeran)FDA LinkGeneric
01/2013
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2013
1bortezomib (Velcade)FDA Link
01/2013
1Streptozocin (Streptozotocin)FDA Link
09/2012
1Chromogranin AIBA
09/2012
1Fluorouracil (Carac)FDA LinkGeneric
09/2012
1irinotecan (Camptosar)FDA LinkGeneric
04/2012
1Cytarabine (Cytosar-U)FDA LinkGeneric
04/2012
1polo-like kinase 1IBA
04/2012
1Proteins (Proteins, Gene)IBA
10/2010
1PHA 680626IBA
12/2008
1Biological Markers (Surrogate Marker)IBA
01/2008
1tyrosine receptor (receptor, tyrosine)IBA
12/2007
13-aminopyrazoleIBA
12/2007
1PHA 680632IBA
07/2006
1Tumor Viral Antigens (Large T Antigen)IBA
01/2004

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
09/2012 - 07/2006
1Cell Transplantation
09/2012
1Oral Administration
04/2012